INT188714

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.44
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
nasal 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 130 99.68 Very High Very High Very High
Inflammatory response 4 97.68 Very High Very High Very High
Inflammatory mediators 11 92.32 High High
Inflammation 82 86.20 High High
Inflammatory stimuli 2 67.20 Quite High
Adalimumab 73 64.76 Quite High
agonist 5 16.60 Low Low
Multiple sclerosis 2 5.68 Low Low
cytokine 17 5.00 Very Low Very Low Very Low
rheumatoid arthritis 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasal Polyps 22 99.70 Very High Very High Very High
Osteoarthritis 132 99.68 Very High Very High Very High
INFLAMMATION 102 97.68 Very High Very High Very High
Polyps 18 87.48 High High
Allergic Rhinitis 18 67.60 Quite High
Apoptosis 1 50.60 Quite High
Cancer 8 50.00 Quite Low
Necrosis 7 50.00 Quite Low
Asthma 10 45.16 Quite Low
Repression 4 36.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine whether these MAPKs are involved in the IL-1-mediated downregulation of PPAR?
Spec (whether) Regulation (involved) of Spec (whether) Negative_regulation (downregulation) of PPAR
1) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.29 Pain Relevance 0.15
To assess the contribution of these pathways in the IL-1-mediated downregulation of PPAR?
Regulation (contribution) of Negative_regulation (downregulation) of PPAR
2) Confidence 0.32 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.15 Pain Relevance 0.08
To evaluate the consequences of the inhibition of PPAR?
Regulation (consequences) of Negative_regulation (inhibition) of PPAR
3) Confidence 0.28 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906797 Disease Relevance 0 Pain Relevance 0.11
Thus, the beneficial effect of glucocorticoid treatment on nasal polyposis may adversely affect the down-regulation of PPAR?.
Spec (may) Regulation (affect) of Negative_regulation (regulation) of PPAR in nasal associated with nasal polyps
4) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 0.99 Pain Relevance 0.28

General Comments

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