INT188715

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.25
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PPARA) nucleoplasm (PPARA) small molecule metabolic process (PPARA)
nucleus (PPARA) DNA binding (PPARA) lipid metabolic process (PPARA)
Anatomy Link Frequency
nasal 2
PPARA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 2 97.68 Very High Very High Very High
Inflammatory mediators 6 92.32 High High
Inflammation 57 85.76 High High
Inflammatory stimuli 1 57.76 Quite High
Osteoarthritis 65 54.32 Quite High
agonist 9 16.16 Low Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nasal Polyps 21 99.48 Very High Very High Very High
INFLAMMATION 68 97.68 Very High Very High Very High
Polyps 18 87.04 High High
Repression 2 77.52 Quite High
Allergic Rhinitis 18 67.16 Quite High
Osteoarthritis 66 54.32 Quite High
Apoptosis 1 50.16 Quite High
Obesity 54 47.36 Quite Low
Asthma 8 44.72 Quite Low
Cancer 5 23.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the beneficial effect of glucocorticoid treatment on nasal polyposis may adversely affect the down-regulation of PPAR?.
Negative_regulation (down) of Negative_regulation (regulation) of PPAR in nasal associated with nasal polyps
1) Confidence 0.37 Published 2005 Journal Respir Res Section Body Doc Link PMC1298337 Disease Relevance 0.99 Pain Relevance 0.27
We found that SB203580 and SP600125 – specific inhibitors of the MAPKs p38 and JNK, respectively – almost completely abolished the IL-1-mediated downregulation of PPAR?
Negative_regulation (abolished) of Negative_regulation (downregulation) of PPAR
2) Confidence 0.30 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906809 Disease Relevance 0.11 Pain Relevance 0.06
The presence of an extra 30 aminoacids in the AF-1 domain of PPAR?
Negative_regulation (presence) of Negative_regulation (domain) of PPAR
3) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.16 Pain Relevance 0.04

General Comments

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