INT18872

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 8.48
Pain Relevance 5.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
PGE1 3
blood 1
1A2 1
external 1
pulmonary artery 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 43 100.00 Very High Very High Very High
ketamine 2 99.32 Very High Very High Very High
anesthesia 17 98.60 Very High Very High Very High
cva 17 93.64 High High
Antinociceptive 22 88.72 High High
Angina 1 87.44 High High
Morphine 1 84.16 Quite High
adenocard 31 83.60 Quite High
Codeine 1 83.12 Quite High
intrathecal 4 82.24 Quite High
Disease Link Frequency Relevance Heat
Nephrotoxicity 5 100.00 Very High Very High Very High
Cancer 3 99.96 Very High Very High Very High
Hypoxia 12 99.80 Very High Very High Very High
Embolism 4 99.64 Very High Very High Very High
Papillomavirus Infection 2 98.16 Very High Very High Very High
Pressure Volume 2 Under Development 2 98.12 Very High Very High Very High
Thrombosis 3 97.92 Very High Very High Very High
Reflex Sympathetic Dystrophy 1 97.32 Very High Very High Very High
Increased Venous Pressure Under Development 7 97.24 Very High Very High Very High
Hepatotoxicity 11 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After curative resection of the tumor, serum PAP levels were significantly decreased.
Negative_regulation (decreased) of serum PAP associated with cancer
1) Confidence 0.43 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10389686 Disease Relevance 1.11 Pain Relevance 0.06
With the use of the external reservoir, proximal hypertension could be abolished and the PAP maintained at target pressures.
Negative_regulation (abolished) of PAP in external
2) Confidence 0.40 Published 1996 Journal Stroke Section Body Doc Link 8841344 Disease Relevance 0 Pain Relevance 0
The negative impact of reduced HPV may have been lessened by gravitational distribution of blood flow and dobutamine-mediated reduction in PAP in our patients.
Negative_regulation (reduction) of PAP in blood associated with papillomavirus infection
3) Confidence 0.36 Published 1990 Journal Chest Section Abstract Doc Link 2331907 Disease Relevance 0.55 Pain Relevance 0.07
By contrast, pretreatment with the MFO inhibitor piperonyl butoxide decreased APAP nephrotoxicity but not that of PAP.
Negative_regulation (decreased) of PAP associated with nephrotoxicity and paracetamol
4) Confidence 0.36 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.67 Pain Relevance 1.06
The detection limit of PAP is 0.10 micro mol L(-1) (3 s) with a relative standard deviation (RSD) of 2.0% for 10 repetitive determinations of 1.0 micro mol L(-1) PAP.
Negative_regulation (limit) of PAP associated with reflex sympathetic dystrophy
5) Confidence 0.35 Published 2003 Journal Anal Bioanal Chem Section Abstract Doc Link 12560974 Disease Relevance 0.10 Pain Relevance 0.17
Neither pulmonary vasodilatation therapy with the inspiration of high oxygen concentration nor intravenous administration of vasodilators (ATP or prostaglandin-I2) could decrease the PAP, but resulted in the exacerbation of systemic arterial hypotension.
Negative_regulation (decrease) of PAP associated with pressure volume 2 under development and increased venous pressure under development
6) Confidence 0.32 Published 2004 Journal Masui Section Abstract Doc Link 15071887 Disease Relevance 0.74 Pain Relevance 0.24
PAP tended to decrease before the apparent improvement of PaO2 in each patient.
Negative_regulation (decrease) of PAP
7) Confidence 0.30 Published 1993 Journal Masui Section Abstract Doc Link 8468787 Disease Relevance 0.81 Pain Relevance 0.62
M) did not inhibit recombinant mouse PAP when AMP was used as substrate (data not shown).
Negative_regulation (inhibit) of PAP
8) Confidence 0.28 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.23
RESULTS: Only PGE1 and PGI2 decreased both PAP and pulmonary vascular resistance (PVR).
Negative_regulation (decreased) of PAP in PGE1
9) Confidence 0.23 Published 1991 Journal Crit. Care Med. Section Body Doc Link 1986891 Disease Relevance 0 Pain Relevance 0
Both PGE1 and PGI2 effectively decrease PAP and PVR.
Negative_regulation (decrease) of PAP in PGE1
10) Confidence 0.23 Published 1991 Journal Crit. Care Med. Section Body Doc Link 1986891 Disease Relevance 0 Pain Relevance 0
PGE1 decreased PAP from 39 +/- 1 to 33 +/- 1 mm Hg; prostacyclin decreased PAP from 38 +/- 1 to 31 +/- 1 mm Hg and produced the largest increase in cardiac output (Qt).
Negative_regulation (decreased) of PAP in PGE1
11) Confidence 0.20 Published 1991 Journal Crit. Care Med. Section Body Doc Link 1986891 Disease Relevance 0 Pain Relevance 0
In group S, pulmonary artery pressure (PAP) decreased before incision.
Negative_regulation (decreased) of PAP in pulmonary artery
12) Confidence 0.15 Published 1989 Journal J Cardiothorac Anesth Section Abstract Doc Link 2521026 Disease Relevance 0.28 Pain Relevance 0.11
Treatment is aimed at lowering PAP, increasing cardiac output, and decreasing in situ thrombosis.
Negative_regulation (lowering) of PAP associated with thrombosis
13) Confidence 0.04 Published 2000 Journal Heart Dis Section Abstract Doc Link 11728293 Disease Relevance 1.33 Pain Relevance 0.17
Immediately after the procedure, the mean PAP decreased from 61 to 30 mmHg.
Negative_regulation (decreased) of PAP
14) Confidence 0.04 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2700243 Disease Relevance 0.60 Pain Relevance 0.04
In microsomal incubations, PEITC effectively inhibited the rate of APAP-glutathione formation from APAP as well as the P450 2E1-dependent N-nitrosodimethylamine demethylase and the P450 1A2-dependent ethoxyresorufin O-deethylase activities.
Negative_regulation (inhibited) of 2E1-dependent in 1A2 associated with paracetamol
15) Confidence 0.03 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9194414 Disease Relevance 0.45 Pain Relevance 1.41
Both inhibitors, applied just before and during 1-wk hypoxia, equally reduced pulmonary arterial pressure (PAP) measured under ketamine+xylazine anesthesia.
Negative_regulation (reduced) of PAP associated with anesthesia, ketamine and hypoxia
16) Confidence 0.03 Published 2006 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 16113050 Disease Relevance 1.29 Pain Relevance 0.28
After this procedure, the mean PAP had decreased from 40 to 29 mmHg.
Negative_regulation (decreased) of PAP
17) Confidence 0.03 Published 2007 Journal Cardiovasc Intervent Radiol Section Body Doc Link PMC2700243 Disease Relevance 0.25 Pain Relevance 0.12
An S-allyl structure appears to be a common feature for most sulfides to inhibit P450 2E1-dependent activity and to display good protective activities.
Negative_regulation (inhibit) of 2E1-dependent
18) Confidence 0.01 Published 1996 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8560468 Disease Relevance 0.32 Pain Relevance 0.83

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