INT188737

Context Info Confidence 0.21 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.04

plasma membrane (Egfr, EGFR) nucleus (Egfr, EGFR) endosome (Egfr, EGFR) cell morphogenesis (Egfr, EGFR) endoplasmic reticulum (Egfr, EGFR) Golgi apparatus (Egfr, EGFR)

Anatomy Link Frequency GBM 1 Egfr (Mus musculus) EGFR (Homo sapiens)

Pain Link Frequency Relevance Heat Central nervous system 1 84.36 palliative 1 5.00 cva 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Glioblastoma 22 99.50 Central Nervous System Cancer 1 84.36 Malignant Neoplastic Disease 2 82.80 Cancer 23 79.08 Glioma 3 32.80 Neuroepithelial Neoplasms 9 5.00 Disease 9 5.00 Necrosis 4 5.00 Pressure And Volume Under Development 2 5.00 Thrombosis 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The most frequent genetic alteration associated with GBM is amplification of the epidermal growth factor receptor (EGFR) gene, which results in over expression of the EGFR, a transmembrane tyrosine kinase receptor [6].

EGFR Positive_regulation (results) of epidermal growth factor receptor in GBM associated with glioblastoma

1) Confidence 0.21 Published 2005 Journal J Transl Med Section Body Doc Link PMC1298339 Disease Relevance 0.60 Pain Relevance 0.04

General Comments

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