INT188756

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 43
Total Number 47
Disease Relevance 23.67
Pain Relevance 2.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGRP) extracellular region (AGRP) Golgi apparatus (AGRP)
Anatomy Link Frequency
neurons 2
blood 1
impressions 1
T-cell 1
AGRP (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropeptide 6 100.00 Very High Very High Very High
Inflammatory marker 4 100.00 Very High Very High Very High
Inflammation 176 99.02 Very High Very High Very High
alcohol 301 98.72 Very High Very High Very High
cytokine 199 97.96 Very High Very High Very High
palliative 31 93.84 High High
cocaine 14 88.32 High High
chemokine 28 86.44 High High
Central nervous system 137 85.08 High High
antagonist 47 72.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 194 100.00 Very High Very High Very High
Congenital Anomalies 18 100.00 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 888 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1958 99.36 Very High Very High Very High
Infection 873 99.20 Very High Very High Very High
Premature Birth 145 99.12 Very High Very High Very High
Mental Disorders 75 98.84 Very High Very High Very High
Birth Weight 13 98.60 Very High Very High Very High
Death 199 97.92 Very High Very High Very High
Leukocytosis 84 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rapid increase in ART initiations after March 2007 might indicate that losses are high, making it possible to initiate more new patients on treatment.
Positive_regulation (increase) of ART
1) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.32 Pain Relevance 0
The orexigenic effect arises by combined activation of neuropeptide Y/agouti-related peptide (NPY/AGRP) and orexin A neurons [314, 318–322].
Positive_regulation (activation) of agouti-related in neurons associated with neuropeptide
2) Confidence 0.45 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.07 Pain Relevance 0.12
Statistical data of accumulated ART cases [36] shows that one out of every 100 babies is born by IVF.
Positive_regulation (accumulated) of ART
3) Confidence 0.44 Published 2006 Journal BMC Med Ethics Section Body Doc Link PMC1481581 Disease Relevance 0.08 Pain Relevance 0
To show that there are limitations to achieve these targets in weak health systems, and to demonstrate that it is possible for local planners in low income countries, to set more achievable targets, we worked out a simple method to estimate the maximum possible number of patients that could access ART in Tanzania.
Positive_regulation (access) of ART
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.42 Pain Relevance 0
Based on our situation analysis, the resulting assumptions and the above-defined formula, we created five scenarios with varying levels of staff productivity and patient loss, to demonstrate the effect on the number patients that could access ART (ART output) in Tanzania.
Positive_regulation (access) of ART
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.09 Pain Relevance 0
Finally, we calculated the ART output and the number of life years that could be saved for five different scenarios with three different levels of clinical staff productivity and patient losses.
Positive_regulation (calculated) of ART
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.12 Pain Relevance 0
Our assumption that clinicians rather than nurses, pharmacists and counselors, will be the main limiting factor for ART scale-up may be either overly optimistic or overly pessimistic given the lack of existing evidence of clinician-time requirements for ART patients, but it does not restrict the use of the model since it can be applied to any type of limiting staff category.
Positive_regulation (requirements) of ART
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.19 Pain Relevance 0
However, we asked HBC staff to refer to our study only those patients who had been screened for ART eligibility using WHO staging.
Positive_regulation (screened) of ART
8) Confidence 0.43 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.44 Pain Relevance 0.07
We found that HBC patients also had substantially greater negative perceptions about ART than those on ART, and these negative perceptions were common, regardless of the study site.
Positive_regulation (perceptions) of ART
9) Confidence 0.43 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.16 Pain Relevance 0
We found that HBC patients also had substantially greater negative perceptions about ART than those on ART, and these negative perceptions were common, regardless of the study site.
Positive_regulation (perceptions) of ART
10) Confidence 0.43 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.16 Pain Relevance 0
Individuals who choose not to initiate ART are difficult to access as they do not present at a facility for HIV care.
Neg (not) Positive_regulation (initiate) of ART associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.43 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.66 Pain Relevance 0.14
Thus, by working with HBC programmes to enrol HBC patients, we were able to select a sample of ill patients who had chosen not to initiate ART.
Neg (not) Positive_regulation (initiate) of ART
12) Confidence 0.43 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.56 Pain Relevance 0.09
Additional work needs to be done to address the attendant issues of: low birth weight and possible increases in morbidity associated with ART, inequity in access to ART as well as access to preterm birth support as a consequence of ART, guidelines for the responsible use of ART; and attitudes and beliefs surrounding the value trade-offs that parents must make surrounding the use of ART, such as delayed reproduction and increased risk for preterm birth.
Positive_regulation (access) of ART associated with birth weight and premature birth
13) Confidence 0.42 Published 2010 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC2841776 Disease Relevance 0.54 Pain Relevance 0
A possible increase in the number of qualified health staff for ART will also compete with other important health care needs including other priority HIV interventions, such as male circumcision [35], [36], PMTCT or HIV research projects.
Spec (possible) Positive_regulation (increase) of ART associated with acquired immune deficiency syndrome or hiv infection
14) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2667213 Disease Relevance 0.27 Pain Relevance 0
In resource-limited settings, the number on treatment has increased dramatically since the large-scale roll out of ART.
Positive_regulation (increased) of ART
15) Confidence 0.40 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.18 Pain Relevance 0
Despite the ever-increasing availability of ART in these settings, however, some patients eligible for treatment do not initiate ART even when it is available to them.
Neg (not) Positive_regulation (initiate) of ART
16) Confidence 0.40 Published 2010 Journal J Int AIDS Soc Section Body Doc Link PMC2847987 Disease Relevance 0.18 Pain Relevance 0
About 20% of twins and 35–40% of triplets are probably from ovulation induction without ART, and about 15% of twins and 40–45% of triplet births result from ART [14].
Positive_regulation (induction) of ART
17) Confidence 0.39 Published 2006 Journal Matern Child Health J Section Body Doc Link PMC1592158 Disease Relevance 0.26 Pain Relevance 0
A recent randomised trial conducted in Haiti comparing patients who started ART early (<350 cells/?
Positive_regulation (started) of ART
18) Confidence 0.38 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 1.09 Pain Relevance 0.06
L, still less than half of those eligible for treatment in the developing world are receiving ART.
Positive_regulation (receiving) of ART
19) Confidence 0.38 Published 2010 Journal BMC Int Health Hum Rights Section Body Doc Link PMC2864209 Disease Relevance 0.15 Pain Relevance 0
Roger Cardinal later defined a category he called “Outsider Art,” which included Art Brut and also the work of folk artists, primitive artists, and untrained artists without mental illness who were indifferent to the prevailing culture.
Positive_regulation (called) of Art associated with mental disorders
20) Confidence 0.34 Published 2008 Journal GMS Psycho-Social Medicine Section Body Doc Link PMC2736519 Disease Relevance 0.60 Pain Relevance 0.03

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