INT188775

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 12.40
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IFIH1) nucleus (IFIH1) intracellular (IFIH1)
helicase activity (IFIH1) DNA binding (IFIH1) cytoplasm (IFIH1)
Anatomy Link Frequency
plasma 2
urine 2
IFIH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cholecystokinin 8 87.44 High High
Nicotine 77 82.44 Quite High
Inflammation 129 73.36 Quite High
fibrosis 7 58.24 Quite High
cytokine 28 34.32 Quite Low
chemokine 17 33.52 Quite Low
Inflammatory response 2 30.80 Quite Low
adenocard 1 14.48 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 1 100.00 Very High Very High Very High
Stress 94 99.82 Very High Very High Very High
Hepatitis C Virus Infection 72 99.82 Very High Very High Very High
Lymphatic Filariasis 239 99.28 Very High Very High Very High
Hyperplasia 2 99.16 Very High Very High Very High
Nicotine Addiction 309 99.08 Very High Very High Very High
Lymphedema 112 97.72 Very High Very High Very High
Infection 74 96.92 Very High Very High Very High
Disease 94 93.96 High High
Body Weight 24 87.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extension of benefits to individuals beyond those directly receiving MDA or infected with LF accentuates the wider community economic impact of the GPELF.
MDA Binding (receiving) of associated with lymphatic filariasis
1) Confidence 0.16 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.08 Pain Relevance 0
More importantly, it showed that targeting these predictors and barriers in a timely and clear pre-MDA educational campaign can increase compliance with MDA programs, and it demonstrated, for the first time, that lymphedema management programs may also increase compliance with MDA programs.


MDA Binding (compliance) of associated with lymphedema
2) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2900179 Disease Relevance 1.08 Pain Relevance 0
They are, in decreasing order of strength of association: knowing about the MDA in advance of its occurrence (OR?
MDA Binding (knowing) of
3) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2900179 Disease Relevance 0.94 Pain Relevance 0
Finally, there was an interaction between knowing about the MDA in advance and knowing everyone was at risk for LF.
MDA Binding (interaction) of associated with lymphatic filariasis
4) Confidence 0.06 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2900179 Disease Relevance 0.66 Pain Relevance 0
RIG-1 senses triphosphorylated single stranded HCV RNA and MDA5 recognizes dsRNA.
MDA5 Binding (recognizes) of associated with hepatitis c virus infection
5) Confidence 0.05 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.96 Pain Relevance 0.03
When adjusted for baseline differences in age, GFR, the oxidative stress markers MDA in urine and plasma, and C-reactive protein did not diminish the elevated REE attributable to smoking (Table 4).
MDA Neg (not) Binding (diminish) of in urine associated with stress and nicotine addiction
6) Confidence 0.04 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 2.34 Pain Relevance 0.10
Other adjustments, such as that for age, CRP, urine and plasma MDA also did not remove the association of increased REE with smoking.
MDA Binding (association) of in plasma associated with nicotine addiction
7) Confidence 0.04 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 1.17 Pain Relevance 0.03
Other adjustments, such as that for age, CRP, urine and plasma MDA also did not remove the association of increased REE with smoking.
MDA Binding (association) of in urine associated with nicotine addiction
8) Confidence 0.01 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 1.17 Pain Relevance 0.03
When adjusted for baseline differences in age, GFR, the oxidative stress markers MDA in urine and plasma, and C-reactive protein did not diminish the elevated REE attributable to smoking (Table 4).
MDA Neg (not) Binding (diminish) of in plasma associated with stress and nicotine addiction
9) Confidence 0.01 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 2.34 Pain Relevance 0.10
They can be recognized by both TLR3 [18] and the melanoma differentiation-associated gene-5 (MDA-5) [19], pattern recognition receptors that are expressed by many cell types and are involved in anti-viral immune responses [20].
MDA-5 Binding (recognized) of associated with skin cancer
10) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.48 Pain Relevance 0
One other interpretation may be that H2O2 induced p-ERK activation and MDA formation are not involved in cellular proliferation.
MDA Binding (formation) of associated with hyperplasia
11) Confidence 0.01 Published 2008 Journal Tob Induc Dis Section Body Doc Link PMC2556029 Disease Relevance 0.20 Pain Relevance 0.32

General Comments

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