INT188776

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 9.93
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IFIH1) nucleus (IFIH1) intracellular (IFIH1)
helicase activity (IFIH1) DNA binding (IFIH1) cytoplasm (IFIH1)
Anatomy Link Frequency
plasma 2
IFIH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 22 99.96 Very High Very High Very High
Inflammation 68 97.88 Very High Very High Very High
fibrosis 7 65.72 Quite High
chemokine 9 51.40 Quite High
cytokine 29 38.68 Quite Low
Inflammatory response 4 38.28 Quite Low
Pain 13 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Pain management 3 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Psoriasis 40 99.96 Very High Very High Very High
Nicotine Addiction 78 99.84 Very High Very High Very High
Lymphatic Filariasis 417 99.74 Very High Very High Very High
INFLAMMATION 72 97.88 Very High Very High Very High
Stress 66 97.72 Very High Very High Very High
Infection 104 97.44 Very High Very High Very High
Disease 250 96.20 Very High Very High Very High
Lymphedema 168 93.96 High High
Phobia 12 93.32 High High
Coronary Artery Disease 1 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The previous section defined a 4-part benefit cohort population as the group of protected individuals who will realize economic benefits as a result of MDA activity between 2000–2007.
Positive_regulation (result) of MDA
1) Confidence 0.23 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.13 Pain Relevance 0
As seen in Table 5, the efforts in reaching and administering MDA to such a large population have produced extraordinary economic benefits over the first 8 years of the GPELF.
Positive_regulation (administering) of MDA
2) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 0.79 Pain Relevance 0
Furthermore, high coverage rates in areas undergoing MDA allow a subgroup of untreated individuals to be protected from infection, subsequent clinical disease, and the incurrence of economic costs as a result of reduced rates of LF transmission.
Positive_regulation (undergoing) of MDA associated with lymphatic filariasis, disease and infection
3) Confidence 0.21 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2879371 Disease Relevance 1.17 Pain Relevance 0
Multivariable predictors of adherence amenable to educational intervention were: 1) knowing about the MDA in advance of its occurrence, 2) knowing everyone is at risk for LF, 3) knowing that the MDA was for LF, and 4) knowing at least one component of the lymphedema management techniques taught in the lymphedema management program.


Positive_regulation (knowing) of MDA associated with lymphatic filariasis and lymphedema
4) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Abstract Doc Link PMC2900179 Disease Relevance 1.06 Pain Relevance 0
Finally, although there is a definitive baseline MDA compliance for the Com-MDA+LM area, the baseline for the Com-MDA and the MDA-only areas are based on less direct empirical data.
Positive_regulation (compliance) of MDA
5) Confidence 0.08 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2900179 Disease Relevance 0.25 Pain Relevance 0
Plasma and urinary MDA were significantly increased in smokers reflecting the heightened state of oxidative stress.
Positive_regulation (increased) of MDA in Plasma associated with stress and nicotine addiction
6) Confidence 0.08 Published 2005 Journal BMC Nephrol Section Body Doc Link PMC1308817 Disease Relevance 2.10 Pain Relevance 0.12
It is not apparent why serum MDA levels were significantly higher in the CoQ10 group compared to placebo group following the Wingate anaerobic capacity test and aerobic capacity test.
Positive_regulation (higher) of serum MDA
7) Confidence 0.07 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.69 Pain Relevance 0
Those who only knew everyone was at risk for LF had a small increase in MDA compliance.
Positive_regulation (increase) of MDA associated with lymphatic filariasis
8) Confidence 0.07 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2900179 Disease Relevance 0.64 Pain Relevance 0
One is mediated by retinoic acid inducible gene-I (RIG-I) retinoic acid/MDA5 while MyD88 (myeloid differentiation primary response gene 88) activates the other.
Positive_regulation (inducible) of MDA5
9) Confidence 0.06 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 1.13 Pain Relevance 0.03
In the plasma and red blood cells of patients with active psoriasis, increased levels of malonyl dialdehyde (MDA) were interpreted as the fingerprint of the exhaustion of natural enzymatic and nonenzymatic antioxidant defenses and consequently the prevalence of deleterious peroxidative processes in the cell membranes and plasma lipids of circulating cells [28, 29].
Positive_regulation (increased) of MDA in plasma associated with psoriasis
10) Confidence 0.02 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.98 Pain Relevance 0.20

General Comments

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