INT188789

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.60
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 2
pad (Mus musculus)
Mthfr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Restless leg syndrome 44 97.36 Very High Very High Very High
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Peripheral Arterial Disease 240 100.00 Very High Very High Very High
Diabetes Mellitus 120 99.24 Very High Very High Very High
Atherosclerosis 84 97.36 Very High Very High Very High
Hypertension 36 96.44 Very High Very High Very High
Nicotine Addiction 44 95.56 Very High Very High Very High
Hyperhomocysteinemia 8 81.44 Quite High
Disorder Of Lipid Metabolism 12 75.00 Quite High
Disease 8 48.08 Quite Low
Stress 4 28.48 Quite Low
Pain 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multivariate logistic regression (Table 4) revealed that MTHFR 677C>T genotype was still significantly associated, albeit marginally, with increased risk of PAD [OR 3.54 (1.01, 12.4), P = 0.049], after adjustment for age, sex, duration of diabetes, hypertension, current smoking habits, and use of insulin or oral treatment for diabetes.
PAD Binding (associated) of MTHFR associated with nicotine addiction, diabetes mellitus, hypertension and peripheral arterial disease
1) Confidence 0.06 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 1.64 Pain Relevance 0.15
Further detailed clinical measurements would have helped to provide insight on the relationships between MTHFR genotype, plasma homocysteine concentration, and PAD.
PAD Binding (genotype) of MTHFR in plasma associated with peripheral arterial disease
2) Confidence 0.05 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 0.47 Pain Relevance 0
Our finding of a significant association between MTHFR genotype and PAD for subjects with type 2 diabetes is novel, to our knowledge.
PAD Binding (association) of MTHFR associated with diabetes mellitus and peripheral arterial disease
3) Confidence 0.05 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 2.02 Pain Relevance 0.16
Further detailed clinical measurements would have helped to provide insight on the relationships between MTHFR genotype, plasma homocysteine concentration, and PAD.
PAD Binding (genotype) of MTHFR in plasma associated with peripheral arterial disease
4) Confidence 0.05 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC1308829 Disease Relevance 0.47 Pain Relevance 0

General Comments

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