INT188799

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.98
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex assembly (Traf6) protein complex (Traf6) ligase activity (Traf6)
cytoplasm (Traf6) signal transducer activity (Traf6) cytosol (Traf6)
Anatomy Link Frequency
osteoclasts 2
Traf6 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 66 95.56 Very High Very High Very High
Inflammation 72 76.96 Quite High
Arthritis 37 73.72 Quite High
antagonist 7 18.20 Low Low
rheumatoid arthritis 57 16.40 Low Low
Inflammatory mediators 1 11.92 Low Low
Inflammatory stimuli 4 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 14 99.36 Very High Very High Very High
Osteoporosis 54 98.48 Very High Very High Very High
Disease 31 80.56 Quite High
INFLAMMATION 70 76.96 Quite High
Atherosclerosis 3 75.44 Quite High
Arthritis 46 73.72 Quite High
Asthma 1 71.92 Quite High
Autoimmune Disease 2 71.04 Quite High
Apoptosis 6 64.68 Quite High
Pressure And Volume Under Development 10 63.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
activates the ubiquitin-proteasome pathway within the osteoclasts, resulting in the degradation of TRAF6 [38].


Positive_regulation (resulting) of Protein_catabolism (degradation) of TRAF6 in osteoclasts
1) Confidence 0.19 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 1.29 Pain Relevance 0.30
in vitro inhibits murine osteoclasto-genesis by inducing the rapid degradation of the RANK adapter protein TRAF6, resulting in strong inhibition of RANKL-induced activation of NF?
Positive_regulation (inducing) of Protein_catabolism (degradation) of TRAF6
2) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.37 Pain Relevance 0.17
in vitro inhibits murine osteoclasto-genesis by inducing the rapid degradation of the RANK adapter protein TRAF6, resulting in strong inhibition of RANKL-induced activation of NF?
Positive_regulation (resulting) of Protein_catabolism (degradation) of TRAF6
3) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592787 Disease Relevance 0.32 Pain Relevance 0.15

General Comments

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