INT1888

Context Info Confidence 0.99 First Reported 1977 Last Reported 2010 Negated 0 Speculated 2 Reported most in Abstract Documents 97 Total Number 100 Disease Relevance 63.48 Pain Relevance 14.82

extracellular region (F13A1) transferase activity, transferring acyl groups (F13A1) cytoplasm (F13A1)

Anatomy Link Frequency plasma 16 blood 8 platelet 6 cleavage 3 PGE1 2 F13A1 (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 92 99.60 IPN 6 98.84 Inflammation 100 98.50 cva 133 98.12 metalloproteinase 78 97.72 cytokine 28 97.02 depression 9 95.60 Spontaneous pain 1 95.56 Restless leg syndrome 10 95.32 Pain 58 95.20

Disease Link Frequency Relevance Heat Cancer 246 100.00 Thrombocytopenia 184 99.96 Apoptosis 43 99.96 Acute-phase Reaction 3 99.84 Injury 324 99.72 Cv General 3 Under Development 105 99.60 Hypocalcemia 8 99.60 Rupture 3 99.36 Obstructive Sleep Apnea 163 99.32 Thrombosis 150 99.32

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In the absence of biological tests and a posteriori the authors discuss the diagnosis of cryoglobulinaemia and intravascular disseminated coagulopathy; but in fact, these two syndromes produce very similar cutaneous symptoms, notably, cryofibrinogenaemias, cryofibrinogen being a degradation product of fibrin liberated in C.

Protein_catabolism (degradation) of fibrin associated with cryoglobulinemia, coagulation disorder and syndrome

1) Confidence 0.99 Published 1977 Journal Rev Stomatol Chir Maxillofac Section Abstract Doc Link 270795 Disease Relevance 0.94 Pain Relevance 0.08

The response of fibrin degradation products to heparan sulphate treatment was more positive and differed significantly from that obtained using sulodexide (p less than 0.001).

Protein_catabolism (degradation) of fibrin

2) Confidence 0.87 Published 1991 Journal Minerva Cardioangiol Section Abstract Doc Link 1780078 Disease Relevance 0.45 Pain Relevance 0.10

Topical treatment modalities have been found to influence reepithelialization, granulation tissue formation, the degradation of fibrin and necrotic tissue, the incidence of wound infections, the pH of the wound as well as airborne dispersal of bacteria, pain and cost of care.

Protein_catabolism (degradation) of fibrin in granulation associated with pain, injury and wound infection

3) Confidence 0.80 Published 1995 Journal Ostomy Wound Manage Section Abstract Doc Link 7669199 Disease Relevance 0.67 Pain Relevance 0.17

The Kaleff-Hollwich modification proved successful and is extended by a fibrin sealing method.

Protein_catabolism (extended) of fibrin

4) Confidence 0.71 Published 1986 Journal Doc Ophthalmol Section Abstract Doc Link 3780377 Disease Relevance 1.43 Pain Relevance 0.24

The laboratory manifestations included severe thrombocytopenia, fibrin degradation products but no presence of schistocytes or fragmented red blood cells.

Protein_catabolism (degradation) of fibrin in red blood cells associated with thrombocytopenia

5) Confidence 0.57 Published 2003 Journal Ugeskr. Laeg. Section Abstract Doc Link 12715677 Disease Relevance 0.61 Pain Relevance 0.10

Although elevated levels of fibrin degradation products were found in most patients, disseminated intravascular coagulation could not be diagnosed.

Protein_catabolism (degradation) of fibrin associated with thrombosis

6) Confidence 0.57 Published 1980 Journal Trop Geogr Med Section Abstract Doc Link 7423600 Disease Relevance 1.14 Pain Relevance 0.17

Eosinophilia, monocytosis, mild hypocalcemia and an increase in fibrin degradation products were seen in a few patients.

Protein_catabolism (degradation) of fibrin associated with hypocalcemia and eosinophilia

7) Confidence 0.53 Published 1987 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 3664933 Disease Relevance 1.75 Pain Relevance 0.18

These findings include the nephrotic syndrome, great variability in proteinuria and glomerular filtration rate, pulmonary embolization, sterile pyuria, hematuria, hyperchloremic acidosis, decreased renal tubular threshold for glucose and increased fibrin degradation products.

Protein_catabolism (degradation) of fibrin associated with acidosis, pyuria, proteinuria, hematuria and disorder of lipid metabolism

8) Confidence 0.53 Published 1977 Journal Am. J. Med. Section Abstract Doc Link 900143 Disease Relevance 0.73 Pain Relevance 0

Significant changes in hemocoagulative and hemorheological parameters were also observed (euglobulin lysis time, fibrin degradation products, erythrocytic filtration, hematic viscosity) and their positive trend may account for peripheral hematic perfusion, as shown by photoplethysmographic tests, velocimetric tests and the modification of the Windsor index.

Protein_catabolism (degradation) of fibrin

9) Confidence 0.53 Published 1991 Journal Minerva Cardioangiol Section Abstract Doc Link 1787894 Disease Relevance 0.15 Pain Relevance 0.15

Fibrin degradation product D-dimer in the diagnosis of pulmonary embolism.

Protein_catabolism (degradation) of Fibrin associated with pulmonary embolism and cva

10) Confidence 0.42 Published 1991 Journal Klin. Wochenschr. Section Title Doc Link 1921237 Disease Relevance 0.67 Pain Relevance 0.29

Plasma levels of peptide B beta, a product of fibrin degradation by human neutrophil elastase, were approximately 15-fold higher (p less than 0.001) in patients with unstable angina or AMI (588 +/- 171 pmol/l, mean +/- SEM) compared with those in patients with stable angina (37 +/- 25 pmol/l) or control subjects (40 +/- 22 pmol/l), confirming intense in vivo neutrophil activation.

Protein_catabolism (degradation) of fibrin in neutrophil associated with angina and myocardial infarction

11) Confidence 0.38 Published 1989 Journal Circulation Section Abstract Doc Link 2537159 Disease Relevance 1.49 Pain Relevance 0.74

The initial mechanics of the FA-IPN are determined by the composite material, and subsequent degradation of fibrin by the encapsulated cells would produce a material with mechanical properties due to the alginate alone.

Protein_catabolism (degradation) of fibrin associated with ipn

12) Confidence 0.31 Published 2009 Journal Biomaterials Section Abstract Doc Link 19616843 Disease Relevance 0 Pain Relevance 0.26

Using a mouse model, two-layered secondary follicles were encapsulated in FA-IPNs, and growth, morphology, hormone production, fibrin degradation rate and the numbers of competent eggs were assessed.

Protein_catabolism (degradation) of fibrin in eggs

13) Confidence 0.31 Published 2009 Journal Biomaterials Section Abstract Doc Link 19616843 Disease Relevance 0 Pain Relevance 0.25

The study objective was to determine the specificity and sensitivity of plasma concentrations of D-dimer, a fibrin degradation product, as a marker for ongoing thrombotic and thrombolytic events in pulmonary embolism.

Protein_catabolism (degradation) of fibrin in plasma associated with pulmonary embolism and cva

14) Confidence 0.27 Published 1991 Journal Klin. Wochenschr. Section Abstract Doc Link 1921237 Disease Relevance 0.59 Pain Relevance 0.25

The most promising approaches involve the measurement in plasma of markers of fibrin formation and degradation.

Protein_catabolism (degradation) of fibrin in plasma

15) Confidence 0.23 Published 1999 Journal Int. J. Cardiol. Section Abstract Doc Link 10328612 Disease Relevance 0.73 Pain Relevance 0.07

Fibrin has been an attractive biomaterial because it is biocompatible and biodegradable.

Protein_catabolism (biodegradable) of Fibrin

16) Confidence 0.22 Published 2008 Journal Knee Surg Sports Traumatol Arthrosc Section Body Doc Link PMC2688024 Disease Relevance 0.31 Pain Relevance 0.03

We studied patients with intermittent claudication to see if the progression of peripheral arterial disease and the risks of coronary events could be predicted by baseline packed cell volume, plasma fibrinogen, blood and plasma viscosites, von Willebrand factor antigen, cross-linked fibrin degradation products (XLFDP), urinary fibrinopeptide A, and plasma leucocyte elastase.

Protein_catabolism (degradation) of fibrin in plasma associated with restless leg syndrome and peripheral arterial disease

17) Confidence 0.21 Published 1993 Journal Lancet Section Abstract Doc Link 8100915 Disease Relevance 0.85 Pain Relevance 0.10

We conclude that, in patients with peripheral arterial disease, plasma concentration of XLFDP, a measure of ongoing fibrin formation and degradation, is a strong predictor of both disease progression and future coronary risk.

Protein_catabolism (degradation) of fibrin in plasma associated with peripheral arterial disease and disease progression

18) Confidence 0.21 Published 1993 Journal Lancet Section Abstract Doc Link 8100915 Disease Relevance 0.98 Pain Relevance 0.06

FDP: fibrin degradation products; MDCT: multi-detector computed tomography; TAE: transcatheter arterial embolization.

Protein_catabolism (degradation) of fibrin

19) Confidence 0.20 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936318 Disease Relevance 0.54 Pain Relevance 0

Despite the blood counts becoming normal after TAE, fibrin degradation products (FDP) and D-dimer decreased after the surgical removal of the tumor.

Protein_catabolism (degradation) of fibrin in blood associated with cancer

20) Confidence 0.20 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936318 Disease Relevance 0.94 Pain Relevance 0

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