INT18881

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Context Info
Confidence 0.41
First Reported 1985
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 7
Total Number 14
Disease Relevance 4.28
Pain Relevance 3.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 2
DRG 2
spinal 1
vasculature 1
hepatocytes 1
Asap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 30 99.84 Very High Very High Very High
Spinal cord 112 98.92 Very High Very High Very High
Pain 22 97.96 Very High Very High Very High
Calcitonin gene-related peptide 7 96.60 Very High Very High Very High
Kinase C 7 74.00 Quite High
Neuropathic pain 7 65.80 Quite High
adenocard 7 63.12 Quite High
imagery 2 47.84 Quite Low
substance P 7 26.60 Quite Low
Opioid 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Pulmonary Alveolar Proteinosis 6 100.00 Very High Very High Very High
Disease 24 99.74 Very High Very High Very High
Nephrotoxicity 12 99.64 Very High Very High Very High
Pain 20 97.96 Very High Very High Very High
Nociception 70 97.84 Very High Very High Very High
Pulmonary Hypertension 83 93.00 High High
Hepatotoxicity 2 90.44 High High
Increased Venous Pressure Under Development 6 87.60 High High
Necrosis 4 83.04 Quite High
Reprotox - General 1 7 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since the antibody used has been characterized as being directed primarily against the N-acetyl moiety of bound APAP metabolite and since it did not react with kidney proteins of mice given a nephrotoxic dose of PAP, it is unlikely that APAP deacetylation preceded binding or that acetylation of bound PAP occurred.
PAP Binding (bound) of in kidney associated with paracetamol
1) Confidence 0.41 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.58 Pain Relevance 0.98
Here, we generated a new antibody that recognizes PAP in mouse and rat tissues and used it for comparative studies in DRG and dorsal spinal cord.


PAP Binding (recognizes) of in spinal cord associated with spinal cord
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.14 Pain Relevance 0.17
Although a rare condition, pulmonary alveolar proteinosis (PAP) can be a very devastating diagnosis with life-altering consequences.
PAP Binding (diagnosis) of associated with pulmonary alveolar proteinosis
3) Confidence 0.37 Published 2005 Journal J. Perianesth. Nurs. Section Abstract Doc Link 15806528 Disease Relevance 0.63 Pain Relevance 0.06
In addition, 78.6% of the women associated a Pap smear with embarrassment.
Pap Binding (associated) of
4) Confidence 0.30 Published 2001 Journal Cancer Nurs Section Abstract Doc Link 11219425 Disease Relevance 0.42 Pain Relevance 0.28
However, this antibody did not recognize PAP in rat DRG neurons or spinal axon terminals (data not shown).
PAP Neg (not) Binding (recognize) of in spinal
5) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.07 Pain Relevance 0.06
We next triple-immunostained lumbar DRG and spinal cord sections from the rat to determine if our polyclonal antibody also recognized PAP in rat tissues.
PAP Binding (recognized) of in spinal cord associated with spinal cord
6) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0.16 Pain Relevance 0.22
To determine if our chicken antibody recognized PAP in a similar population of DRG neurons and axon terminals, we triple-immunostained mouse DRG and spinal cord with our chicken antibody and various markers (Figure 2).
PAP Binding (recognized) of in neurons associated with spinal cord
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2800773 Disease Relevance 0 Pain Relevance 0.13
At the time, we were unable to determine if PAP was present in rat DRG neurons because the antibody we used did not cross-react with PAP in rat tissues.
PAP Neg (not) Binding (react) of in DRG
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.26 Pain Relevance 0.08
At the time, we were unable to determine if PAP was present in rat DRG neurons because the antibody we used did not cross-react with PAP in rat tissues.
PAP Neg (not) Binding (cross) of in DRG
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.27 Pain Relevance 0.08
In the rat, 92.5% of all PAP+ cells bind the nonpeptidergic marker IB4 and 31.8% of all PAP+ cells contain the peptidergic marker CGRP.
PAP Binding (bind) of in IB4
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2800773 Disease Relevance 0.23 Pain Relevance 0.16
Immunochemical analysis of kidneys from APAP-treated mice demonstrated covalently bound APAP but no binding was detected after mice were treated with a nephrotoxic dose of PAP.
PAP Neg (no) Binding (binding) of associated with paracetamol
11) Confidence 0.28 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.65 Pain Relevance 1.07
In conclusion, we found that PAP was metabolized in hepatocytes predominantly to PAP-GSH conjugates and PAP-N-acetylcysteine conjugates in sufficient quantities to account for the nephrotoxicity of PAP.
PAP Binding (account) of in hepatocytes associated with nephrotoxicity
12) Confidence 0.15 Published 2000 Journal Drug Metab. Dispos. Section Abstract Doc Link 10901695 Disease Relevance 0.10 Pain Relevance 0.36
The catheter also determines disease severity by determining the PAP accurately, is the only reliable means to date of determining pulmonary vascular resistance and tests the vasoreactivity of the pulmonary vasculature.
PAP Spec (determining) Binding (determining) of in vasculature associated with disease
13) Confidence 0.02 Published 2008 Journal Archives of Disease in Childhood Section Body Doc Link PMC2532955 Disease Relevance 0.69 Pain Relevance 0
Double immunostained preparations using glucose oxidase-antiglucose oxidase complex combined with PAP complex to visualize two antigens with contrasting colors in the same tissue section were employed.
PAP Binding (complex) of
14) Confidence 0.02 Published 1985 Journal Peptides Section Abstract Doc Link 3001668 Disease Relevance 0.09 Pain Relevance 0

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