INT18882

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Context Info
Confidence 0.49
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 1.15
Pain Relevance 13.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
urine 4
liver 2
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 167 100.00 Very High Very High Very High
Bile 10 96.52 Very High Very High Very High
Inflammation 1 83.08 Quite High
Analgesic 1 81.64 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 98.80 Very High Very High Very High
Hepatotoxicity 5 95.64 Very High Very High Very High
Nephrotoxicity 5 94.92 High High
Stress 2 83.08 Quite High
INFLAMMATION 1 83.08 Quite High
Toxicity 1 79.28 Quite High
Weight Loss 1 69.28 Quite High
Breast Cancer 1 46.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In multiple regression analysis, the release of APAP at pH 4.0 was found to increase markedly as the concentration of AMCE increased, whereas the release of APAP at pH 6.5 decreased as the EC concentration increased, even when a high level of AMCE was incorporated.
Negative_regulation (decreased) of Localization (release) of APAP associated with paracetamol
1) Confidence 0.49 Published 2010 Journal Int J Pharm Section Abstract Doc Link 20472050 Disease Relevance 0 Pain Relevance 0.93
At pH 1.16, a decline in the percentage of APAP released occurred after 18 hours.
Negative_regulation (decline) of Localization (released) of APAP associated with paracetamol
2) Confidence 0.36 Published 1997 Journal Pharm Dev Technol Section Abstract Doc Link 9552442 Disease Relevance 0.13 Pain Relevance 0.99
Preferential secretion of APAP-glu into blood decreased enterohepatic recirculation of APAP, thus attenuating liver exposition to the intact drug, as demonstrated 6h after administration with the toxic dose.
Negative_regulation (decreased) of Localization (secretion) of APAP in liver associated with paracetamol
3) Confidence 0.29 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19426699 Disease Relevance 0.24 Pain Relevance 1.36
Prior inhibition of APAP deacetylation by the carboxylesterase inhibitors bis(p-nitrophenyl) phosphate or tri-o-tolyl-phosphate did not alter APAP hepatotoxicity or nephrotoxicity.
Negative_regulation (inhibition) of Localization (deacetylation) of APAP associated with nephrotoxicity, paracetamol and hepatotoxicity
4) Confidence 0.11 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.62 Pain Relevance 0.90
The cumulative amounts of APAP-CG/CYS and APAP-NAC excreted in urine of mutant rats were decreased, whereas APAP-GLU was markedly increased.
Negative_regulation (decreased) of Localization (excreted) of APAP in urine associated with paracetamol
5) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12756215 Disease Relevance 0 Pain Relevance 1.51
Our results support the direct involvement of Mrp2 in the hepatobiliary excretion of several conjugated metabolites of APAP, including APAP-GSH and APAP-NAC, and provide relevant information on processes that may be involved with both their hepatic basolateral transport and renal elimination.
Negative_regulation (metabolites) of Localization (excretion) of APAP associated with paracetamol
6) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12756215 Disease Relevance 0 Pain Relevance 1.46
Our results support the direct involvement of Mrp2 in the hepatobiliary excretion of several conjugated metabolites of APAP, including APAP-GSH and APAP-NAC, and provide relevant information on processes that may be involved with both their hepatic basolateral transport and renal elimination.
Negative_regulation (metabolites) of Localization (excretion) of APAP associated with paracetamol
7) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12756215 Disease Relevance 0 Pain Relevance 1.46
Our results support the direct involvement of Mrp2 in the hepatobiliary excretion of several conjugated metabolites of APAP, including APAP-GSH and APAP-NAC, and provide relevant information on processes that may be involved with both their hepatic basolateral transport and renal elimination.
Negative_regulation (metabolites) of Localization (excretion) of APAP associated with paracetamol
8) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12756215 Disease Relevance 0 Pain Relevance 1.46
The cumulative amounts of APAP-CG/CYS and APAP-NAC excreted in urine of mutant rats were decreased, whereas APAP-GLU was markedly increased.
Negative_regulation (decreased) of Localization (excreted) of APAP in urine associated with paracetamol
9) Confidence 0.08 Published 2003 Journal Drug Metab. Dispos. Section Abstract Doc Link 12756215 Disease Relevance 0 Pain Relevance 1.51
Although elimination of the parent APAP was minimally affected, biliary excretion of APAP glucuronide was significantly decreased 70 and 80%, whereas urinary excretion was significantly increased 90 and 100% in the groups pretreated with single and repeated doses of APAP, respectively, relative to vehicle controls.
Negative_regulation (decreased) of Localization (excretion) of APAP associated with paracetamol
10) Confidence 0.04 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16109740 Disease Relevance 0.16 Pain Relevance 1.12
Intestinal excretion of APAP-GLU was unchanged or decreased (-58%) by BDL for the 150 mg and 1 g/kg b.w. doses of APAP, respectively.
Negative_regulation (decreased) of Localization (excretion) of APAP-GLU associated with paracetamol
11) Confidence 0.01 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18096675 Disease Relevance 0 Pain Relevance 0.80

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