INT18884

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2010
Negated 11
Speculated 2
Reported most in Abstract
Documents 25
Total Number 27
Disease Relevance 11.43
Pain Relevance 23.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RYBP) nucleus (RYBP) intracellular (RYBP)
DNA binding (RYBP) cytoplasm (RYBP)
Anatomy Link Frequency
hepatocytes 2
plasma 1
liver 1
bile 1
knee 1
RYBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 362 100.00 Very High Very High Very High
addiction 1 100.00 Very High Very High Very High
Bile 12 99.92 Very High Very High Very High
Pain 5 99.44 Very High Very High Very High
Central nervous system 1 97.92 Very High Very High Very High
Osteoarthritis 2 97.72 Very High Very High Very High
aspirin 2 96.52 Very High Very High Very High
Analgesic 8 96.24 Very High Very High Very High
cytokine 5 86.40 High High
ischemia 1 83.44 Quite High
Disease Link Frequency Relevance Heat
Toxicity 44 99.96 Very High Very High Very High
Hepatotoxicity 32 99.96 Very High Very High Very High
Pain 4 99.44 Very High Very High Very High
Nephrotoxicity 15 99.24 Very High Very High Very High
Injury 26 98.56 Very High Very High Very High
Necrosis 15 98.36 Very High Very High Very High
Knee Osteoarthritis 2 97.92 Very High Very High Very High
Sprains And Strains 3 97.40 Very High Very High Very High
Poisoning 5 97.36 Very High Very High Very High
Stress 8 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although, which central effects are largely responsible for APAP's effects on pain continue to be uncertain.
Regulation (responsible) of APAP associated with pain and paracetamol
1) Confidence 0.38 Published 2009 Journal Pain Physician Section Abstract Doc Link 19165309 Disease Relevance 0.27 Pain Relevance 1.56
In contrast, the excretion of APAP-NAC did not exhibit dependence on APAP-GSH concentration.
Regulation (dependence) of APAP-GSH associated with addiction
2) Confidence 0.36 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2871175 Disease Relevance 0 Pain Relevance 0.19
Co-ingested DPH had no significant effect on APAP absorption, except a 6% decrease in the AUC.
Neg (no) Regulation (effect) of APAP
3) Confidence 0.24 Published 2005 Journal Acad Emerg Med Section Body Doc Link 15692141 Disease Relevance 0.06 Pain Relevance 0
The results indicate that CFB pretreatment does not affect the total amount of APAP and its metabolites excreted in bile.
Neg (not) Regulation (affect) of APAP in bile associated with bile and paracetamol
4) Confidence 0.24 Published 2000 Journal Xenobiotica Section Abstract Doc Link 11197064 Disease Relevance 0 Pain Relevance 1.20
The results showed that the correlation coefficient between the APAP value measured by the Acetaminophen Detection Kit and that determined by the HPLC method was, at 0.888, not very high, but that the decision on whether to administer NAC based on the measured APAP level was consistent between the two analytical methods in 23 out of 25 patients.
Regulation (value) of APAP associated with paracetamol
5) Confidence 0.23 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18176068 Disease Relevance 0.40 Pain Relevance 0.47
Also, the overall metabolism of APAP was not altered by castration, as there were no significant differences in the 24-hr excretion of APAP urinary metabolites between castrated and sham-operated mice.
Neg (not) Regulation (altered) of APAP associated with paracetamol
6) Confidence 0.23 Published 1994 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 8209379 Disease Relevance 0.40 Pain Relevance 1.35
OBJECTIVE: To compare the safety and efficacy of acetaminophen extended-release (APAP ER) with rofecoxib for the management of pain associated with knee osteoarthritis (OA).
Regulation (efficacy) of APAP in knee associated with pain, paracetamol, knee osteoarthritis and osteoarthritis
7) Confidence 0.23 Published 2009 Journal Osteoarthr. Cartil. Section Abstract Doc Link 18640856 Disease Relevance 0.27 Pain Relevance 0.36
APAP pre-treatment induced a partial shift from biliary to urinary elimination of APAP-Glu after administration with the toxic dose, and decreased hepatic content and increased serum content of this conjugate, consistent with a marked up-regulation of its basolateral transporter Mrp3 relative to apical Mrp2.
Regulation (regulation) of APAP associated with paracetamol
8) Confidence 0.20 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19426699 Disease Relevance 0.27 Pain Relevance 1.40
The APAP cytotoxicity was dependent on the concentration of APAP and time of exposure, and could be blocked by 4-methylpyrazole, ethanol, diallyl sulfide, N-acetylcysteine and N-t-butyl-alpha-phenylnitrone, but not by propylgallate, an inhibitor of lipid peroxidation.
Regulation (dependent) of APAP associated with paracetamol
9) Confidence 0.18 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791125 Disease Relevance 0.26 Pain Relevance 0.89
Northern blots were used to examine the effects of acetaminophen (APAP) on CYP3A4-mRNA.
Spec (examine) Regulation (effects) of APAP associated with paracetamol
10) Confidence 0.13 Published 2002 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 11811955 Disease Relevance 0 Pain Relevance 0.64
Taurine increased the plasma concentrations of APAP-glutathione (GSH) and APAP-mercapturate, but the APAP-glucuronide or APAP-sulfate concentration was not changed.
Neg (not) Regulation (changed) of APAP in plasma associated with paracetamol
11) Confidence 0.10 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15516725 Disease Relevance 0.16 Pain Relevance 1.39
Pretreatment with BCNU or DFO did not affect APAP oxidation as determined by the formation of the APAP-GSH conjugate or the covalent binding of APAP metabolites to cellular protein.
Neg (not) Regulation (affect) of APAP associated with paracetamol
12) Confidence 0.08 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8517869 Disease Relevance 0.49 Pain Relevance 0.91
These results indicate that the enhancement of APAP nephrotoxicity in the fructose-pretreated rats is due, at least in part, to an alteration in metabolic pathways of APAP.
Regulation (alteration) of APAP associated with nephrotoxicity and paracetamol
13) Confidence 0.08 Published 1997 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 9455675 Disease Relevance 0.40 Pain Relevance 0.94
The present study investigated the effects of PEITC on APAP metabolism and associated hepatotoxicity in Swiss-Webster mice.
Spec (investigated) Regulation (effects) of APAP associated with paracetamol and hepatotoxicity
14) Confidence 0.08 Published 1997 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 9194414 Disease Relevance 0.46 Pain Relevance 0.60
Prior inhibition of APAP deacetylation by the carboxylesterase inhibitors bis(p-nitrophenyl) phosphate or tri-o-tolyl-phosphate did not alter APAP hepatotoxicity or nephrotoxicity.
Neg (not) Regulation (alter) of APAP associated with nephrotoxicity, paracetamol and hepatotoxicity
15) Confidence 0.06 Published 1991 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1987650 Disease Relevance 0.62 Pain Relevance 0.97
Cumulatively, the data show that treatment with hrVEGF reduced toxicity and increased hepatocyte regeneration in APAP toxicity in the mouse.
Regulation (regeneration) of APAP in hepatocyte associated with toxicity and paracetamol
16) Confidence 0.04 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20363854 Disease Relevance 0.60 Pain Relevance 0.83
Acetaminophen t1/2 was not altered in TA-treated rats, indicating that significant changes in APAP disposition and bioactivation are unlikely.
Regulation (changes) of APAP associated with paracetamol
17) Confidence 0.04 Published 1995 Journal Hepatology Section Abstract Doc Link 7843722 Disease Relevance 0.27 Pain Relevance 0.97
These data suggest that the organic anion ICG has a protective effect on APAP toxicity that promotes a faster recovery from liver injury.
Regulation (effect) of APAP in liver associated with toxicity and injury
18) Confidence 0.04 Published 2001 Journal Food Chem. Toxicol. Section Abstract Doc Link 11278059 Disease Relevance 0.58 Pain Relevance 0.10
After administration of a nontoxic dose of APAP, biliary concentrations of APAP-sulfate, APAP-glucuronide (APAP-GLUC), and APAP-glutathione were reduced in MCD rats.
Regulation (concentrations) of APAP-glucuronide associated with paracetamol
19) Confidence 0.02 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.89 Pain Relevance 1.18
After administration of a nontoxic dose of APAP, biliary concentrations of APAP-sulfate, APAP-glucuronide (APAP-GLUC), and APAP-glutathione were reduced in MCD rats.
Regulation (concentrations) of APAP-GLUC associated with paracetamol
20) Confidence 0.02 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17640958 Disease Relevance 0.90 Pain Relevance 1.18

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