INT188855

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 1.97
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pde2a) signal transduction (Pde2a) Golgi apparatus (Pde2a)
endoplasmic reticulum (Pde2a) plasma membrane (Pde2a) nucleus (Pde2a)
Anatomy Link Frequency
paw 4
cardiac myocytes 2
Pde2a (Mus musculus)
Pain Link Frequency Relevance Heat
analgesia 8 99.06 Very High Very High Very High
Morphine 64 97.62 Very High Very High Very High
Eae 24 93.76 High High
qutenza 4 92.80 High High
Spinal cord 116 91.04 High High
Inflammatory stimuli 4 89.16 High High
Pain 44 75.88 Quite High
allodynia 40 22.44 Low Low
agonist 8 20.04 Low Low
Dorsal horn 4 17.68 Low Low
Disease Link Frequency Relevance Heat
Nociception 100 99.48 Very High Very High Very High
Inflammatory Pain 16 93.76 High High
INFLAMMATION 12 88.80 High High
Targeted Disruption 8 82.00 Quite High
Coronary Heart Disease 52 79.84 Quite High
Sprains And Strains 16 79.08 Quite High
Pain 52 75.88 Quite High
Neuropathic Pain 44 75.08 Quite High
Natriuresis 20 59.80 Quite High
Body Weight 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, our findings are compatible with the notion that PKG I is the downstream target activated by the ANP/GC-A/cGMP-signalling pathway in cardiac myocytes. cGMP/PKG I-mediated modulation of RGS2 and subsequent inhibition of AT1/G?
Positive_regulation (mediated) of Gene_expression (modulation) of cGMP in cardiac myocytes
1) Confidence 0.12 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0 Pain Relevance 0
Counteraction of the cardiac Ang II effects by ANP/GC-A/cGMP involves PKG I and RGS2
Positive_regulation (by) of Gene_expression (/) of cGMP
2) Confidence 0.12 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.14 Pain Relevance 0
Counteraction of the cardiac Ang II effects by ANP/GC-A/cGMP involves PKG I and RGS2
Positive_regulation (by) of Gene_expression (/) of cGMP
3) Confidence 0.12 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.14 Pain Relevance 0
In contrast, nitric oxide (NO)-stimulated cGMP production in the cytosol (which is mediated by the soluble guanylyl cyclase, sGC), markedly blunted the cardiac contractile responses to ISO [44, 50].
Positive_regulation (stimulated) of Gene_expression (production) of cGMP
4) Confidence 0.11 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC2916114 Disease Relevance 0.28 Pain Relevance 0
It was observed that the injection of a dose of morphine prior to formalin injection providing no more than 2 hours of analgesia in these mice [17] eliminated the wide-spread enhancement of expression of CO/NO-cGMP system genes.
Positive_regulation (enhancement) of Gene_expression (expression) of cGMP associated with analgesia and morphine
5) Confidence 0.07 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.23 Pain Relevance 0.28
Thus it appears both that 1) the enhanced expression of CO/NO-cGMP system genes requires the intense acute nociception characteristic of formalin injection, and 2) that long term hind paw sensitisation does not require enhanced expression of these genes.
Positive_regulation (enhanced) of Gene_expression (expression) of cGMP in paw associated with nociception
6) Confidence 0.07 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.30 Pain Relevance 0.32
Thus it appears both that 1) the enhanced expression of CO/NO-cGMP system genes requires the intense acute nociception characteristic of formalin injection, and 2) that long term hind paw sensitisation does not require enhanced expression of these genes.
Positive_regulation (requires) of Gene_expression (expression) of cGMP in paw associated with nociception
7) Confidence 0.07 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.30 Pain Relevance 0.32
Once produced, these monoxides converge on guanylate cyclase to stimulate the production of cGMP.
Positive_regulation (stimulate) of Gene_expression (production) of cGMP
8) Confidence 0.07 Published 2005 Journal Mol Pain Section Body Doc Link PMC1310513 Disease Relevance 0.58 Pain Relevance 0.61

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox