INT188883

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 11.55
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (DDX41) RNA binding (DDX41) nucleus (DDX41)
helicase activity (DDX41)
Anatomy Link Frequency
sinus 1
M-1 1
DDX41 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 30 94.48 High High
Adalimumab 16 91.48 High High
ischemia 16 89.56 High High
Infliximab 14 88.60 High High
withdrawal 5 83.20 Quite High
beta blocker 40 82.00 Quite High
Catecholamine 8 75.04 Quite High
Demyelination 21 73.32 Quite High
spinal inflammation 2 72.88 Quite High
Arthritis 36 71.52 Quite High
Disease Link Frequency Relevance Heat
Syndrome 294 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 60 100.00 Very High Very High Very High
Neuromyelitis Optica 282 99.98 Very High Very High Very High
Malignant Neoplastic Disease 88 99.76 Very High Very High Very High
Arrhythmia Under Development 144 99.46 Very High Very High Very High
Heart Rate Under Development 50 99.12 Very High Very High Very High
Recurrence 22 99.00 Very High Very High Very High
Disease 98 98.80 Very High Very High Very High
Cv Unclassified Under Development 20 98.30 Very High Very High Very High
Coronary Stenosis 4 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A few prior reports have, however, demonstrated occasional apparent association between ABS and both significant bradyarrhythmia and tachycardia [3,4].
ABS Binding (association) of associated with heart rate under development and syndrome
1) Confidence 0.39 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2490812 Disease Relevance 2.01 Pain Relevance 0.05
This finding suggests that the PR prolongation is not from intrinsic AV nodal conduction disease but from sympathovagal imbalance as a previously suggested abnormality in ABS [11].
ABS Neg (not) Binding (abnormality) of associated with syndrome and disease
2) Confidence 0.30 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2490812 Disease Relevance 1.20 Pain Relevance 0.04
Alternative possibilities include preexisting conduction abnormalities in patients with atrial fibrillation (sick sinus syndrome) or a previously unproven association of atrial fibrillation with ABS.
ABS Binding (association) of in sinus associated with syndrome, cv unclassified under development, arrhythmia under development and arrhythmias 2 under development
3) Confidence 0.29 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2490812 Disease Relevance 1.71 Pain Relevance 0.07
There have been anecdotal reports for significant arrhythmias in patients with ABS [3,4], but the exact association, if any, of ABS with malignant arrhythmias is unknown.
ABS Binding (association) of associated with malignant neoplastic disease and syndrome
4) Confidence 0.29 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2490812 Disease Relevance 1.77 Pain Relevance 0.15
Bivariate analyses to determine crude odds ratios were used to evaluate the degree of association between independent variables and ABs (verbal, physical and both).
ABs Binding (association) of
5) Confidence 0.23 Published 2005 Journal BMC Geriatr Section Body Doc Link PMC1310539 Disease Relevance 0.08 Pain Relevance 0.04
As shown in Figure 1 we found co-localization of NMO Abs (red) with the AQP4 protein (green), whereas NMO Abs did not bind to EmGFP transfected cells.
Abs Neg (not) Binding (bind) of associated with neuromyelitis optica
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 0.40 Pain Relevance 0
M-1 and M-23 AQP4-IgG Abs are significantly associated with a higher number of relapses and longer disease duration.



Abs Binding (associated) of in M-1 associated with disease and recurrence
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2864757 Disease Relevance 2.06 Pain Relevance 0.10
NMO-Ig Abs resulted in different staining patterns when binding to full length AQP4 in contrast to the M-23 AQP4 isoform.
Abs Binding (binding) of associated with neuromyelitis optica
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864757 Disease Relevance 1.22 Pain Relevance 0.06
Antibodies (Abs) were purified by affinity
Abs Binding (affinity) of
9) Confidence 0.03 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.08 Pain Relevance 0
Those results suggested the two Abs would bind the different sites of TNF-?.
Abs Binding (bind) of
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 1.01 Pain Relevance 0.61
, while contrasted with PA, the commercial Abs couldn't bind the peptide (Figure 2).
Abs Binding (bind) of
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2811745 Disease Relevance 0 Pain Relevance 0.16

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