INT18891

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Context Info
Confidence 0.33
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.96
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

HTLVR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.62 Very High Very High Very High
methadone 1 87.76 High High
Dopamine 24 72.52 Quite High
opiate 1 70.24 Quite High
Catecholamine 6 60.40 Quite High
Neurotransmitter 6 57.28 Quite High
adenocard 15 52.40 Quite High
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 40 99.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 19 99.18 Very High Very High Very High
Apoptosis 12 80.56 Quite High
Leukemia 7 72.48 Quite High
Stress 12 68.16 Quite High
Viral Infection 3 65.68 Quite High
Cancer 6 60.08 Quite High
Disorders Of Creatine Metabolism 3 46.16 Quite Low
Htlv Types I And Ii 24 44.68 Quite Low
Lymphatic System Cancer 3 42.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of those, 15 (71%) had HTLV-II-specific sequences by polymerase chain reaction (PCR) and 1 (5%) had both HTLV-I- and -II-specific sequences; 3 persons with indeterminate serologic results were also PCR-positive for HTLV-II.
Positive_regulation (positive) of HTLV-II
1) Confidence 0.33 Published 1991 Journal J. Infect. Dis. Section Abstract Doc Link 1988509 Disease Relevance 0.90 Pain Relevance 0.09
We have found that in an in vitro coinfection system (HIV-1 + HTLV-I), morphine treatment further enhanced the levels of HTLV-I p19.
Positive_regulation (enhanced) of HTLV-I p19 associated with acquired immune deficiency syndrome or hiv infection and morphine
2) Confidence 0.23 Published 1999 Journal DNA Cell Biol. Section Abstract Doc Link 10235111 Disease Relevance 1.66 Pain Relevance 0.48
Spermidine was also upregulated in the 293T-HTLV3 and the 293T-Tax3 cell lines.
Positive_regulation (upregulated) of HTLV3
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.08 Pain Relevance 0.03
In fact, only two metabolites (spermidine and N-acetyl aspartic acid) were upregulated in both HTLV1 transformed and HTLV3 transfected cells.
Positive_regulation (upregulated) of HTLV1
4) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0.21
Interestingly, arginine that is converted into ornithine, the precursor of polyamines in the urea cycle, was also upregulated in HTLV1 transformed cells (quite dramatically for HUT102).
Positive_regulation (upregulated) of HTLV1
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.26 Pain Relevance 0

General Comments

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