INT18893

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 81
Total Number 83
Disease Relevance 38.03
Pain Relevance 34.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 4
neuronal 2
blood 2
ovarian vein 1
nucleus 1
CPP (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2100 100.00 Very High Very High Very High
pain pelvic 95 100.00 Very High Very High Very High
Pain 75 100.00 Very High Very High Very High
Morphine 158 99.98 Very High Very High Very High
cocaine 102 99.98 Very High Very High Very High
Nicotine 109 99.84 Very High Very High Very High
Inflammation 42 99.76 Very High Very High Very High
addiction 102 99.72 Very High Very High Very High
Ventral tegmentum 50 99.66 Very High Very High Very High
Buprenorphine 30 99.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1922 100.00 Very High Very High Very High
Brain Injury 323 100.00 Very High Very High Very High
Reprotox - General 3 95 100.00 Very High Very High Very High
Pain 65 100.00 Very High Very High Very High
Pressure And Volume Under Development 46 99.82 Very High Very High Very High
Meningitis 81 99.76 Very High Very High Very High
Cv General 4 Under Development 184 99.26 Very High Very High Very High
Increased Venous Pressure Under Development 80 99.00 Very High Very High Very High
Bacterial Meningitis 63 98.72 Very High Very High Very High
Brain Death 22 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that MK-801 not only blocks the development of morphine-induced CPP but is also able to block the expression of a conditioned response that has been acquired before.
Positive_regulation (induced) of CPP associated with morphine
1) Confidence 0.69 Published 1997 Journal Behav. Brain Res. Section Abstract Doc Link 9079776 Disease Relevance 0 Pain Relevance 0.90
Finally, in a third experiment, CPP was induced by morphine and amphetamine (animals tested in the drug-free state), and behavioural sensitization was induced by amphetamine.
Positive_regulation (induced) of CPP associated with morphine
2) Confidence 0.69 Published 1997 Journal Behav. Brain Res. Section Abstract Doc Link 9079776 Disease Relevance 0 Pain Relevance 0.97
In a second experiment, it was found that pregabalin (injected once, 24 h after CPP had been demonstrated) was able to reverse morphine-induced CPP.
Positive_regulation (induced) of CPP
3) Confidence 0.60 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0
Furthermore, pregabalin blocked the maintenance of morphine-induced CPP.
Positive_regulation (induced) of CPP
4) Confidence 0.60 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0
In the present study, sucrose solution (15%) was given prior to, during, and following the acquisition of morphine-induced CPP.
Positive_regulation (induced) of CPP associated with morphine
5) Confidence 0.60 Published 2008 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 18485463 Disease Relevance 0 Pain Relevance 0.62
The vast majority of studies have focused on CPP induced by illicit drugs, such as psychostimulants and opioids.
Positive_regulation (induced) of CPP associated with opioid
6) Confidence 0.60 Published 2008 Journal ScientificWorldJournal Section Abstract Doc Link 19082419 Disease Relevance 0.10 Pain Relevance 0.17
The present review discusses the extant research on CPP induced by legal drugs.
Positive_regulation (induced) of CPP
7) Confidence 0.60 Published 2008 Journal ScientificWorldJournal Section Abstract Doc Link 19082419 Disease Relevance 0.08 Pain Relevance 0.25
Our studies show an agreement between misoprostol (stable PGE1 analogue) effect on alleviating morphine-induced experimental pharmaco-dependence and morphine-induced CPP.
Positive_regulation (induced) of CPP associated with addiction and morphine
8) Confidence 0.60 Published 2005 Journal Rev Med Chir Soc Med Nat Iasi Section Abstract Doc Link 16607800 Disease Relevance 0.07 Pain Relevance 0.35
We first describe the CPP model and discuss the behavioral procedures used to induce CPP for ethanol, nicotine, and caffeine.
Positive_regulation (induce) of CPP associated with nicotine
9) Confidence 0.60 Published 2008 Journal ScientificWorldJournal Section Abstract Doc Link 19082419 Disease Relevance 0.08 Pain Relevance 0.26
Surviving patients have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Positive_regulation (increased) of CPP associated with cva
10) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.13 Pain Relevance 0.54
With increased ICP or decreased CPP, StcO2 is reduced.
Positive_regulation (increased) of CPP associated with cva
11) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.64 Pain Relevance 0.57
Good neurological outcome patients also have decreased ICP, increased CPP, decreased CAP Index, increased StcO2, and increased BIS.
Positive_regulation (increased) of CPP associated with cva
12) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.26 Pain Relevance 0.60
Surviving and good neurological outcome patients have increased CPP, StcO2, and BIS and decreased ICP and CAP Index (Table 2).
Positive_regulation (increased) of CPP associated with cva
13) Confidence 0.56 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.79 Pain Relevance 0.35
Lesions of the mesolimbic dopamine system, the ventral pallidum, the lateral nucleus of the amygdala, or the caudate putamen had no effect on a morphine-induced CPP.
Positive_regulation (induced) of CPP in nucleus associated with dopamine, amygdala and morphine
14) Confidence 0.54 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9438800 Disease Relevance 0.23 Pain Relevance 0.77
This study examined the neural substrates underlying the development of a conditioned place preference (CPP) to morphine (2 mg/kg x 3 pairings) by testing whether lesions of 7 different neural sites block a morphine-induced CPP.
Spec (whether) Positive_regulation (induced) of CPP in neural associated with morphine
15) Confidence 0.54 Published 1997 Journal Behav. Neurosci. Section Abstract Doc Link 9438800 Disease Relevance 0.27 Pain Relevance 0.68
CONCLUSIONS: Neither gabapentin nor pregabalin induced CPP, but both compounds blocked the development of CPP to morphine and also blocked morphine's effects on dopamine release.
Neg (Neither) Positive_regulation (induced) of CPP
16) Confidence 0.50 Published 2001 Journal Psychopharmacology (Berl.) Section Body Doc Link 11605097 Disease Relevance 0 Pain Relevance 0
The cHCCs proved to be PCR-positive for canine serum albumin, alpha-fetoprotein and ceruloplasmin.
Positive_regulation (positive) of ceruloplasmin
17) Confidence 0.45 Published 2004 Journal Comp Hepatol Section Body Doc Link PMC535891 Disease Relevance 0.09 Pain Relevance 0.03
Moderate doses of cocaine (5.0 mg/kg) and buprenorphine (0.075 mg/kg), which were individually capable of eliciting CPP, produced a significantly larger CPP when given in combination.
Positive_regulation (eliciting) of CPP associated with buprenorphine and cocaine
18) Confidence 0.45 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1988653 Disease Relevance 0.15 Pain Relevance 1.26
Buprenorphine (0-0.9 mg/kg) also elicited CPP in a dose-related manner; an inverted U-shaped function was obtained.
Positive_regulation (elicited) of CPP associated with buprenorphine
19) Confidence 0.45 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1988653 Disease Relevance 0.16 Pain Relevance 1.06
These results indicate that the PVI is not independent of CPP but is a function of CPP and is profoundly influenced by anesthesia.
Neg (independent) Positive_regulation (independent) of CPP associated with anesthesia
20) Confidence 0.43 Published 1987 Journal J. Neurosurg. Section Abstract Doc Link 3612269 Disease Relevance 0.08 Pain Relevance 0.32

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