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Context Info
Confidence 0.36
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 10.12
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CHGA)
Anatomy Link Frequency
neuron 4
plasma 1
sustentacular cells 1
chromaffin cell 1
Parathyroid 1
CHGA (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 18 100.00 Very High Very High Very High
Catecholamine 8 100.00 Very High Very High Very High
Serotonin 1 99.92 Very High Very High Very High
Thoracotomy 2 92.92 High High
imagery 8 90.96 High High
palliative 3 87.80 High High
pulpitis 1 87.28 High High
anesthesia 1 77.60 Quite High
pain flank 1 75.20 Quite High
agonist 3 70.88 Quite High
Disease Link Frequency Relevance Heat
Renal Failure 1 99.90 Very High Very High Very High
Cancer 131 99.70 Very High Very High Very High
Malignant Neoplastic Disease 17 99.40 Very High Very High Very High
Pheochromocytoma 15 99.20 Very High Very High Very High
Pancreatic Cancer 7 98.76 Very High Very High Very High
Necrosis 8 97.24 Very High Very High Very High
Hypertension 7 96.00 Very High Very High Very High
Prostate Cancer 52 95.72 Very High Very High Very High
Metastasis 42 93.72 High High
Adenoma 1 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renal failure was associated with an elevated plasma chromogranin A independently of blood pressure.
chromogranin A Binding (associated) of in plasma associated with renal failure
1) Confidence 0.36 Published 1991 Journal Medicine (Baltimore) Section Abstract Doc Link 1988765 Disease Relevance 1.59 Pain Relevance 0.16
These tumors tend to have several unique characteristics, including the absence of androgen receptors and PSA production and the presence of a variety of growth factor receptors (i.e. bombesin, somatostatin, chromogranin-A, serotonin and Parathyroid hormone (PTH)).[30] This leads to a clinical presentation quite different from AIPC, with more frequent visceral and soft tissue metastases, osteolytic bone metastases, brain metastases, hypercalcemia and a rapid clinical deterioration.
chromogranin-A Binding (variety) of in Parathyroid associated with cancer, somatostatin, hypercalcemia, prostate cancer, serotonin and metastasis
2) Confidence 0.36 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684340 Disease Relevance 1.45 Pain Relevance 0.10
Tumor cells usually stain positive with chromogranin, synaptophysin and neuron-specific enolase.
chromogranin Binding (stain) of in neuron associated with cancer
3) Confidence 0.36 Published 2008 Journal Cases J Section Body Doc Link PMC2596793 Disease Relevance 0.76 Pain Relevance 0.16
Immunohistochemistry showed strong and diffuse positivity for synaptophysin, chromogranin (Figure 1c), cytokeratin (Figure 1d) Bcl-2 protein and neuron-specific enolase (NSE) but negativity for S100, desmin and epithelial membrane antigen (EMA).
chromogranin Binding (positivity) of in neuron
4) Confidence 0.36 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1971059 Disease Relevance 1.22 Pain Relevance 0
A population of neuroendocrine cells positively reacting to neuron-specific enolase, synaptophysin, chromogranin A, and stained with paraldehyde-fuchsin, was detected in the subodontoblastic layer of the pulp.
chromogranin A Binding (reacting) of in neuron
5) Confidence 0.36 Published 2007 Journal Bull. Exp. Biol. Med. Section Abstract Doc Link 18457032 Disease Relevance 0.07 Pain Relevance 0.09
The pheochromocytes were strongly reactive with chromogranin and the sustentacular cells with S-100 protein, whereas the adrenal cortical cells reacted specifically with inhibin.
chromogranin Binding (reactive) of in sustentacular cells
6) Confidence 0.36 Published 2001 Journal Ann Diagn Pathol Section Abstract Doc Link 11598859 Disease Relevance 0.99 Pain Relevance 0.08
Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A(352-372)) with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism.
chromogranin Binding (Interaction) of in chromaffin cell associated with catecholamine
7) Confidence 0.36 Published 2000 Journal Regul. Pept. Section Title Doc Link 11062327 Disease Relevance 0 Pain Relevance 0.25
Immunohistochemically the tumor was positive to NSE and slightly positive to keratin, but negative to LCA, L26, UCLH-1, EMA, Leu7, and chromogranin, suggesting a malignant tumor derived from neuroendocrine tissue.
chromogranin Binding (negative) of associated with malignant neoplastic disease and cancer
8) Confidence 0.36 Published 1998 Journal Lung Cancer Section Abstract Doc Link 9869108 Disease Relevance 0.97 Pain Relevance 0.17
In the present case, three identical components were clearly identified by phenotypical expression analysis, which correspond to those previously reported with the exception of positive reactivity for chromogranin A.
chromogranin A Neg (exception) Binding (reactivity) of
9) Confidence 0.35 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2874790 Disease Relevance 1.22 Pain Relevance 0.04
The cells were strongly immunopositive for neuron-specific enolase, chromogranin (Figure 4), synaptophysin and pancytokeratin.
chromogranin Binding (neuron-specific enolase) of in neuron
10) Confidence 0.05 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2964737 Disease Relevance 0.72 Pain Relevance 0.08
Some ductal pancreatic carcinomas irrespective of their differentiation show the expression of chromogranin, which is associated with the expression of hMSH2 gene.
chromogranin Binding (associated) of associated with pancreatic cancer
11) Confidence 0.02 Published 2003 Journal Pol J Pathol Section Abstract Doc Link 12817878 Disease Relevance 1.06 Pain Relevance 0.05

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