INT18898

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Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 38
Total Number 41
Disease Relevance 28.99
Pain Relevance 4.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CHGA)
Anatomy Link Frequency
plasma 5
neuron 5
smooth muscle 1
cerebrospinal fluid 1
cleavage 1
CHGA (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 3 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
spastic colon 29 99.56 Very High Very High Very High
Inflammation 14 99.08 Very High Very High Very High
Serotonin 59 98.88 Very High Very High Very High
Inflammatory stimuli 2 98.48 Very High Very High Very High
calcitonin gene related peptide 1 96.60 Very High Very High Very High
abdominal pain 8 96.46 Very High Very High Very High
imagery 66 94.84 High High
Neuropeptide 16 94.64 High High
Disease Link Frequency Relevance Heat
Diarrhoea 38 100.00 Very High Very High Very High
Neuroendocrine Cancer 117 99.96 Very High Very High Very High
Cancer 499 99.90 Very High Very High Very High
Hypertension 17 99.84 Very High Very High Very High
Renal Failure 10 99.84 Very High Very High Very High
Renal Insufficiency 4 99.78 Very High Very High Very High
Paraganglioma 4 99.68 Very High Very High Very High
Carcinoma 49 99.56 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

16 99.56 Very High Very High Very High
Reprotox - General 1 7 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At baseline the CgA was elevated above the normal range in 15 of the patients, and during treatment five patients decreased their CgA to the normal range.
Positive_regulation (elevated) of CgA
1) Confidence 0.67 Published 2006 Journal Prostate Cancer Prostatic Dis. Section Abstract Doc Link 16231013 Disease Relevance 0.41 Pain Relevance 0.24
Revised salivary chromogranin A levels increased in the control and butorphanol groups at the time of entrance to the operating room and after epidural treatment compared with the value of the day before surgery, whereas it did not change statistically in the midazolam group.
Positive_regulation (increased) of chromogranin A
2) Confidence 0.67 Published 2005 Journal J Clin Anesth Section Body Doc Link 16297757 Disease Relevance 0 Pain Relevance 0
We report the case of a 32-year-old Indian man with symptoms suggesting Zollinger-Ellison syndrome including abdominal pain, esaphagitis, duodenal stenosis that did not improve with antisecretory medication, elevated fasting gastrin serum levels that increased after intravenous secretin injections, elevated chromogranin A serum levels and tumoral aspect of pancreatic uncus on CT scan examination.
Positive_regulation (elevated) of chromogranin A in uncus associated with abdominal pain, pathologic constriction and syndrome
3) Confidence 0.67 Published 2005 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 16505764 Disease Relevance 0.67 Pain Relevance 0.10
Plasma radioimmunoassays showed elevated gastrin, chromogranin A and normal levels of gastrin-releasing peptide, and 9 other hormones.
Positive_regulation (elevated) of chromogranin A in Plasma
4) Confidence 0.67 Published 2001 Journal Gastroenterology Section Abstract Doc Link 11266390 Disease Relevance 1.87 Pain Relevance 0.20
The gastrin and chromogranin A levels were markedly elevated (15,590 pg/ml and 584.2 U/l, respectively).
Positive_regulation (elevated) of chromogranin A
5) Confidence 0.67 Published 1998 Journal Dtsch. Med. Wochenschr. Section Body Doc Link 9861888 Disease Relevance 0.18 Pain Relevance 0
In the other 7, there were no cases of carcinoid, n=1 gastric leiomyoma, n=1 rectal tumour and 4 patients had persistently elevated CgA levels but with improvement of symptoms.
Positive_regulation (elevated) of CgA
6) Confidence 0.67 Published 2009 Journal J Gastrointestin Liver Dis Section Body Doc Link 19337629 Disease Relevance 0 Pain Relevance 0
In the 15 patients with elevated CgA levels >60u/l, 8 normalised on repeated testing.
Positive_regulation (elevated) of CgA
7) Confidence 0.67 Published 2009 Journal J Gastrointestin Liver Dis Section Body Doc Link 19337629 Disease Relevance 0 Pain Relevance 0
In general, CgA levels are elevated in 85%–100% of patients with carcinoid tumour, regardless of whether the tumour is functional or nonfunctional.
Positive_regulation (elevated) of CgA associated with carcinoid and cancer
8) Confidence 0.67 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 0.99 Pain Relevance 0.19
Inflammatory conditions and renal insufficiency can cause elevations of CgA and, in rare cases, the cause cannot be identified.
Positive_regulation (elevations) of CgA associated with inflammation and renal insufficiency
9) Confidence 0.67 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 0.82 Pain Relevance 0.12
In classical midgut neuroendocrine tumours, CgA levels are elevated to 100–1000 times normal 20,21.
Positive_regulation (elevated) of CgA in midgut associated with neuroendocrine cancer
10) Confidence 0.67 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 0.89 Pain Relevance 0.17
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Positive_regulation (negative) of chromogranin in thyroid
11) Confidence 0.49 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.59 Pain Relevance 0.08
However, some patients with carcinoid tumour have symptoms of flushing with low or normal levels of 5-hiaa 17,18.

4.2 CgA

Positive_regulation (17,18.) of CgA associated with carcinoid and increased venous pressure under development
12) Confidence 0.49 Published 2006 Journal Current Oncology Section Body Doc Link PMC1891174 Disease Relevance 1.01 Pain Relevance 0.16
Elevated chromogranin A (CgA) serum levels in the patients with advanced pancreatic cancer.
Positive_regulation (Elevated) of CgA associated with pancreatic cancer
13) Confidence 0.49 Published 2009 Journal Arch Gerontol Geriatr Section Title Doc Link 18329114 Disease Relevance 0.46 Pain Relevance 0.37
Elevated chromogranin A (CgA) serum levels in the patients with advanced pancreatic cancer.
Positive_regulation (Elevated) of chromogranin A associated with pancreatic cancer
14) Confidence 0.49 Published 2009 Journal Arch Gerontol Geriatr Section Title Doc Link 18329114 Disease Relevance 0.46 Pain Relevance 0.37
Immunohistochemically, the tumor cells showed strong diffuse positivity for HMB-45 while they were negative for c-kit, smooth muscle actin, cytokeratin, S-100, vimentin, desmin, chromogranin, synaptophysin, EMA, and CD-34.
Positive_regulation (negative) of chromogranin in smooth muscle associated with cancer
15) Confidence 0.49 Published 2007 Journal Tumori Section Abstract Doc Link 17455882 Disease Relevance 0.56 Pain Relevance 0.13
Strong positive reactions for chromogranin A and NSE were observed in almost all tumor cells in the lesion.
Positive_regulation (reactions) of chromogranin A associated with cancer
16) Confidence 0.49 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2834672 Disease Relevance 1.10 Pain Relevance 0.03
Immunohistochemical studies in five cases showed staining of most cells in the solid components for cytokeratin and chromogranin A and some to most cells for serotonin and neuron-specific enolase.
Positive_regulation (components) of chromogranin A in neuron associated with serotonin
17) Confidence 0.49 Published 1996 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 8886877 Disease Relevance 1.24 Pain Relevance 0.14
Although measurement of chromogranin A in the bloodstream is of value in sympathoadrenal investigations, little is systematically known about chromogranin A in cerebrospinal fluid, despite substantial knowledge about its occurrence and distribution in brain.
Spec (investigations) Positive_regulation (measurement) of chromogranin A in cerebrospinal fluid
18) Confidence 0.49 Published 1993 Journal Neuroscience Section Abstract Doc Link 7904334 Disease Relevance 0.30 Pain Relevance 0
Immuno-histochemically, the tumor cells were positive for cytokeratin, the epithelial membrane antigen, neuron-specific enolase, and chromogranin, but were negative for the leukocyte common antigen and Grimelius stain.
Positive_regulation (positive) of chromogranin in leukocyte associated with cancer
19) Confidence 0.49 Published 1997 Journal J. Obstet. Gynaecol. Res. Section Abstract Doc Link 9094811 Disease Relevance 1.20 Pain Relevance 0.09
The goal of this study was to characterize the primary sequences of high molecular mass catestatin intermediates and peptides to define the proteolytic cleavage sites within CgA that are utilized in the biosynthesis of catestatin.
Positive_regulation (utilized) of CgA in cleavage
20) Confidence 0.49 Published 2003 Journal Biochemistry Section Abstract Doc Link 12795588 Disease Relevance 0 Pain Relevance 0.09

General Comments

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