INT189034

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.99
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (NOX5) oxidoreductase activity (NOX5) endoplasmic reticulum (NOX5)
Anatomy Link Frequency
muscle 1
germ line 1
lymphoid tissues 1
spermatozoa 1
NOX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 48 91.48 High High
substance P 28 29.28 Quite Low
Inflammatory mediators 15 23.60 Low Low
cytokine 12 21.28 Low Low
calcitonin gene related peptide 16 11.36 Low Low
chemokine 9 10.52 Low Low
antagonist 20 5.00 Very Low Very Low Very Low
qutenza 8 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
TRP channel 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Esophageal Disease 22 98.64 Very High Very High Very High
Stress 44 98.08 Very High Very High Very High
INFLAMMATION 62 91.48 High High
Neurodegenerative Disease 2 84.88 Quite High
Muscle Hypertonia 1 83.04 Quite High
Brain Injury 53 82.76 Quite High
Parkinson's Disease 2 55.04 Quite High
Disease 31 50.00 Quite Low
Emergencies 1 48.28 Quite Low
Gastroesophageal Reflux Disease 12 24.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Definitive evidence for the presence of NOX 5 in human spermatozoa has still not been obtained and we still await independent confirmation of the ability of NOX 5 to generate ROS in spermatozoa.
Gene_expression (generate) of NOX 5 in spermatozoa
1) Confidence 0.48 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.20 Pain Relevance 0
The latter may then serve as a substrate for putative ROS-generating enzymes in the germ line such as NOX 5 [44], and thereby, elicit a state of oxidative stress.
Gene_expression (enzymes) of NOX 5 in germ line associated with stress
2) Confidence 0.42 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1315356 Disease Relevance 0.18 Pain Relevance 0
Nox5, essentially expressed in lymphoid tissues and in testis [146], is distinguished from the other Nox proteins by an additional N-terminal extension containing three canonical and one noncanonical EF-hand motifs.
Gene_expression (expressed) of Nox5 in lymphoid tissues
3) Confidence 0.34 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0 Pain Relevance 0
Whereas NOX1-NOX5 are all present in esophageal circular muscle, only NOX5 mRNA was increased in the human specimen with esophagitis, as shown in Figure 18A.
Gene_expression (present) of NOX1-NOX5 in muscle associated with esophageal disease
4) Confidence 0.17 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 1.07 Pain Relevance 0.10
Several homologs of the catalytic subunit of the enzyme, gp91phox, also termed NOX2, exist (NOX1 through NOX5) [11,12].
Gene_expression (through) of NOX5
5) Confidence 0.08 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.55 Pain Relevance 0

General Comments

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