INT189050

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 4.66
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pla2g2a) extracellular space (Pla2g2a) endoplasmic reticulum (Pla2g2a)
Anatomy Link Frequency
Respiratory 1
Pla2g2a (Mus musculus)
Pain Link Frequency Relevance Heat
cva 28 93.84 High High
Inflammation 30 87.20 High High
anesthesia 24 83.84 Quite High
Inflammatory response 6 5.00 Very Low Very Low Very Low
agonist 6 5.00 Very Low Very Low Very Low
ischemia 3 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
beta blocker 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 44 100.00 Very High Very High Very High
Cv General 4 Under Development 26 98.44 Very High Very High Very High
Stroke 32 98.08 Very High Very High Very High
Hypersensitivity 204 97.88 Very High Very High Very High
Coronary Artery Disease 34 97.24 Very High Very High Very High
Cv General 3 Under Development 28 93.84 High High
Atherosclerosis 26 92.40 High High
Hypertension 24 90.68 High High
Cancer 60 87.76 High High
INFLAMMATION 36 87.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EA conceived of the study, coordinated the research, performed and analysed CD34, VEGF, PLA2, and iNOS staining, VEGF ELISA, CFSE and PI staining, and wrote the manuscript.
Spec (analysed) Regulation (analysed) of PLA2
1) Confidence 0.23 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 0.60 Pain Relevance 0
Taken together these data suggest an effect for the PlA2 gene polymorphism in the development of more severe thrombotic complications in high risk patients.
Regulation (effect) of PlA2 gene
2) Confidence 0.13 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 1.38 Pain Relevance 0.12
Our study suggests that the PlA2 polymorphism is associated with a more aggressive atherothrombotic disease and adversely affects the prognosis in these high risk patients.
Regulation (affects) of PlA2 associated with disease
3) Confidence 0.11 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954874 Disease Relevance 1.11 Pain Relevance 0.04
In contrast, a very good agreement between EF50, GL and Cdyn values was found for control mice, with mean differences ranging from -2.4 to -6.1 %.
Regulation (values) of EF50
4) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.35 Pain Relevance 0
This variability may reflect different sensitivities of GL, EF50 and Cdyn to the airway and tissue components of total pulmonary resistance [3,16].
Regulation (sensitivities) of EF50
5) Confidence 0.05 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.47 Pain Relevance 0.04
Respiratory parameters were averaged in 5 s segments and minimum GL, Cdyn and EF50 values were taken and expressed as percent changes from corresponding baseline values.
Regulation (values) of EF50 in Respiratory
6) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0 Pain Relevance 0.08
MCh exposure elicited a dose-related reduction in GL, Cdyn, and EF50 values in the intubated animals that was significantly enhanced in allergic mice (p < 0.05 vs. control group).
Regulation (values) of EF50 associated with hypersensitivity
7) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.29 Pain Relevance 0
The degree of bronchoconstriction to inhalation challenge was determined from minimum values of EF50 and was expressed as percent changes from corresponding baseline values.


Spec (determined) Regulation (values) of EF50
8) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0 Pain Relevance 0.06
Consistent with previous results, invasively recorded EF50 was slightly less sensitive in detecting the maximum degree of bronchoconstriction to A. fumigatus and MCh compared with GL and Cdyn recordings [15].
Regulation (sensitive) of EF50
9) Confidence 0.04 Published 2005 Journal Respir Res Section Body Doc Link PMC1316879 Disease Relevance 0.46 Pain Relevance 0.03

General Comments

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