INT189088

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2009
Negated 4
Speculated 2
Reported most in Body
Documents 2
Total Number 21
Disease Relevance 18.79
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Psmb9) nucleus (Psmb9) cytoplasm (Psmb9)
Anatomy Link Frequency
thyroid 4
thyroid glands 3
lobes 1
Psmb9 (Mus musculus)
Pain Link Frequency Relevance Heat
Sicca syndrome 20 80.32 Quite High
psoriasis 20 72.56 Quite High
Inflammation 100 71.60 Quite High
spinal inflammation 20 71.16 Quite High
alcohol 20 70.20 Quite High
anesthesia 1 55.68 Quite High
isoflurane 1 55.24 Quite High
cytokine 20 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1000 100.00 Very High Very High Very High
Hypothyroidism 320 99.92 Very High Very High Very High
Carcinoma 160 99.92 Very High Very High Very High
Disease 80 99.92 Very High Very High Very High
Adenoma 120 99.62 Very High Very High Very High
Hashimoto Disease 300 99.56 Very High Very High Very High
Diabetes Mellitus 40 99.38 Very High Very High Very High
Hyperthyroidism 120 98.60 Very High Very High Very High
Thyroid Neoplasm 140 97.64 Very High Very High Very High
Cancer 100 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similarly, the protein levels of LMP2, LMP7, LMP10, PA28?
Gene_expression (levels) of LMP2
1) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.35 Pain Relevance 0
After thyroid lobes were excised and homogenated in TRIZOL (Invitrogen, Carlsbad, CA), total RNA was extracted following manufacture protocol. 10 µg of total RNA was separated by 1% agarose gel electrophoresis and analyzed by Northern blot for the expression of LMP2.
Spec (analyzed) Gene_expression (expression) of LMP2 in lobes
2) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0 Pain Relevance 0
For example, Vives-Pi and colleagues, studying eight patients with Graves disease patients and four with type 1 diabetes, reported that thyroid glands expressed high but variable levels of LMP2 and LMP7, whereas pancreases had levels similar to those found in healthy controls [21].
Gene_expression (expressed) of LMP2 in thyroid glands associated with diabetes mellitus and hyperthyroidism
3) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.16 Pain Relevance 0.15
In patients with Hürthle cell adenomas or carcinomas the expression of LMP2 was clear, although more variable than that observed in Hashimoto thyroiditis.
Gene_expression (expression) of LMP2 associated with adenoma, carcinoma and hashimoto disease
4) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.05 Pain Relevance 0
transgenic mice, instead, was not affected by the absence of LMP2, and lymphocytes could still be seen in the thyroid interstitium of thyr-IFN?
Neg (absence) Gene_expression (absence) of LMP2 in thyroid associated with targeted disruption
5) Confidence 0.75 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.79 Pain Relevance 0
Our finding that only the lack of LMP2, but not LMP7, ameliorated diseases in thyr-IFN?
Neg (lack) Gene_expression (lack) of LMP2 associated with disease
6) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.20 Pain Relevance 0.12
46); LMP2 heterozygous/IFN?
Gene_expression (/) of LMP2
7) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.57 Pain Relevance 0.03
Further studies are also needed to assess whether LMP2 levels correlate with clinical outcomes in patients with Hürthle cell carcinoma.
Spec (whether) Gene_expression (levels) of LMP2 associated with carcinoma
8) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.15 Pain Relevance 0.03
specifically in thyroid follicular cells [5]), LMP2 knockout (N?
Gene_expression (knockout) of LMP2 in thyroid associated with targeted disruption
9) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.48 Pain Relevance 0.03
Interestingly, the lack of LMP2 ameliorated the hypothyroidism seen in thyr-IFN?
Neg (lack) Gene_expression (lack) of LMP2 associated with hypothyroidism
10) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.29 Pain Relevance 0.03
, LMP2 forward primer 5?
Gene_expression (primer) of LMP2
11) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0 Pain Relevance 0
LMP2 was used in this study as a therapeutic target to control with MLN-273 the oncocytes present in transgenic mice over-expressing IFN?
Gene_expression (used) of LMP2 associated with targeted disruption
12) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.21 Pain Relevance 0.04
46); LMP2 heterozygous/IFN?
Gene_expression (heterozygous) of LMP2
13) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.57 Pain Relevance 0.03
LMP2 was also expressed in Hürthle cell adenomas (Figure 5, middle panel) and carcinoma (Figure 5, right panel), although levels varied greatly among patients and different areas of the same specimen (Figure S4A).
Gene_expression (expressed) of LMP2 associated with adenoma and carcinoma
14) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.10 Pain Relevance 0.03
LMP2 was expressed in all 19 Hashimoto thyroiditis specimens (Table 2) with mention of Hürthle cells and in most of those (5 of 6) where Hürthle cells were not mentioned by the pathologist.
Gene_expression (expressed) of LMP2 associated with hashimoto disease
15) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.96 Pain Relevance 0
LMP2 was also found expressed in oncocytes from patients with Hashimoto thyroiditis and Hürthle cell tumors.


Gene_expression (expressed) of LMP2 associated with cancer and hashimoto disease
16) Confidence 0.58 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2773418 Disease Relevance 0.74 Pain Relevance 0
For example, Vives-Pi and colleagues, studying eight patients with Graves disease patients and four with type 1 diabetes, reported that thyroid glands expressed high but variable levels of LMP2 and LMP7, whereas pancreases had levels similar to those found in healthy controls [21].
Gene_expression (levels) of LMP2 in thyroid glands associated with diabetes mellitus and hyperthyroidism
17) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 1.14 Pain Relevance 0.15
Given the key role of LMP2 in the induction of mouse oncocytes, we assessed whether LMP2 was also expressed in archival thyroid glands removed from patients with Hashimoto thyroiditis, Graves disease, Hürthle cell adenoma, or Hürthle cell carcinoma.
Gene_expression (expressed) of LMP2 in thyroid glands associated with adenoma, carcinoma, hyperthyroidism and hashimoto disease
18) Confidence 0.58 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.86 Pain Relevance 0
During these studies we also noted that thyroid follicular cells from mice lacking only LMP2 were flatter than those observed in wild type controls (Figure S2A), suggesting an effect of LMP2 on thyroid hormonogenesis.
Neg (lacking) Gene_expression (lacking) of LMP2 in thyroid
19) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0.89 Pain Relevance 0
Primary antibody was diluted for human thyroid sections as following; LMP2 (1?
Gene_expression (diluted) of LMP2 in thyroid
20) Confidence 0.57 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773418 Disease Relevance 0 Pain Relevance 0.04

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