INT18909

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 92
Total Number 93
Disease Relevance 56.55
Pain Relevance 7.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 59
lung 5
macrophages 2
lymphocytes 2
spleens 2
Cd8a (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 248 100.00 Very High Very High Very High
tolerance 172 99.90 Very High Very High Very High
qutenza 10 99.82 Very High Very High Very High
Inflammation 730 99.52 Very High Very High Very High
cytokine 631 96.56 Very High Very High Very High
Demyelination 276 96.04 Very High Very High Very High
cva 12 92.36 High High
rheumatoid arthritis 52 91.16 High High
Spinal cord 69 90.88 High High
chemokine 80 89.92 High High
Disease Link Frequency Relevance Heat
Influenza Virus Infection 990 100.00 Very High Very High Very High
Targeted Disruption 239 100.00 Very High Very High Very High
Multiple Sclerosis 122 99.98 Very High Very High Very High
Lymphopenia 119 99.98 Very High Very High Very High
Cancer 1266 99.92 Very High Very High Very High
Injury 250 99.84 Very High Very High Very High
Respiratory Syncytial Virus 444 99.68 Very High Very High Very High
Dengue 130 99.62 Very High Very High Very High
INFLAMMATION 870 99.52 Very High Very High Very High
Sprains And Strains 589 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that a significantly higher expression of CD94-NKG2A heterodimer on CD8+T cells was induced following OVA inoculation into the anterior chamber, and that AC-injection of antigen and immunization have a synergistic effect on the increase of CD8+CD94+T cells.
Positive_regulation (increase) of CD8 in T cells associated with immunization
1) Confidence 0.60 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.17 Pain Relevance 0.09
In those studies, the kinetics of reduction in lung virus titer preceded the accumulation of virus-specific NP366–474tetramer+ CD8+ T cells, but reductions partially overlapped peak accumulation of the CD8+ T cells.
Positive_regulation (accumulation) of CD8 in T cells
2) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 0.68 Pain Relevance 0.04
Previous studies have shown that influenza-induced CD8+ T cells reduced pulmonary influenza infection following adoptive transfer.
Positive_regulation (induced) of CD8 in T cells associated with influenza virus infection
3) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.33 Pain Relevance 0
Thus, the present adoptive transfer experiments demonstrate that NP-induced CD8+ CTL can promote clearance of influenza virus infection in epithelial cells lining the respiratory tract.
Positive_regulation (induced) of CD8 in epithelial cells associated with influenza virus infection
4) Confidence 0.45 Published 2007 Journal Respir Res Section Body Doc Link PMC1914056 Disease Relevance 1.09 Pain Relevance 0
Splenic MNC (5 × 104 cells/well, as responder cells) from immunized mice were cocultured with purified CD8+CD94+T or CD8+CD94-T cells (as regulatory cells) from ACAID mice and immunized mice at different responder/suppressor ratios (1:0, 1:0.25, 1:0.5, 1:1) in the presence or absence of OVA(100 ?
Positive_regulation (purified) of CD8 in T cells
5) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05
The suppressive effect of CD8+CD94+T and CD8+CD94-T cells from ACAID mice on the proliferation of splenic MNC from naive mice (at 1:1 ratio) upon anti-CD3 mAb(1 ?
Positive_regulation (effect) of CD8 in T cells
6) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
Using DNA microarray analysis, Keino et al[17] compared patterns of gene expression in regulatory OT-1 CD8+T cells generated in vitro with those from nonregulatory OT-1 CD8+T cells.
Positive_regulation (nonregulatory) of CD8 in T cells
7) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.18 Pain Relevance 0
Splenic MNC (5 × 104 cells/well, as responder cells) from immunized mice were cocultured with purified CD8+CD94+T or CD8+CD94-T cells (as regulatory cells) from ACAID mice and immunized mice at different responder/suppressor ratios (1:0, 1:0.25, 1:0.5, 1:1) in the presence or absence of OVA(100 ?
Positive_regulation (purified) of CD8 in T cells
8) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05
Recent studies reported that one population of CD8+Tregs was associated with Foxp3 expression [41-43], we further examined the expression of Foxp3 by CD8+CD94+T cells.
Positive_regulation (population) of CD8 in T cells
9) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
The suppressive effect of CD8+CD94+T and CD8+CD94-T cells from ACAID mice on the proliferation of splenic MNC from naive mice (at 1:1 ratio) upon anti-CD3 mAb(1 ?
Positive_regulation (effect) of CD8 in T cells
10) Confidence 0.43 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.04
CD8+CD94+T cells from ACAID mice exhibited suppressive activity in association with enhanced expression of TGF-beta1, suggesting that CD8+Treg are mainly distributed in CD94+T cell subpopulations.



Positive_regulation (distributed) of CD8 in T cell
11) Confidence 0.40 Published 2008 Journal BMC Immunol Section Abstract Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.03
Upregulation of the CD94-NKG2A receptor on splenic CD8+T cells of ACAID mice
Positive_regulation (Upregulation) of CD8 in T cells
12) Confidence 0.40 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.07 Pain Relevance 0
These results suggest that CD8+Treg in ACAID are mainly distributed in CD94+T cell subpopulations.


Positive_regulation (distributed) of CD8 in T cell
13) Confidence 0.40 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.08 Pain Relevance 0
Activated CD4+ and CD8+ T lymphocytes upregulate cell surface CD25 after initial binding of the TCR with antigen displayed on MHC [30], [31] and this might explain the apparent decrease in T cells that was observed in tumors (Fig. 4A–B) and dLN (Fig. 4C–D) following administration of PC61.
Positive_regulation (Activated) of CD8 in T cells associated with cancer
14) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.68 Pain Relevance 0
Using DNA microarray analysis, Keino et al[17] compared patterns of gene expression in regulatory OT-1 CD8+T cells generated in vitro with those from nonregulatory OT-1 CD8+T cells.
Positive_regulation (regulatory) of CD8 in T cells
15) Confidence 0.37 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2566975 Disease Relevance 0.18 Pain Relevance 0
This difference also was observed when the number of tetramer/pentamer+CD8+ and IFN?
Positive_regulation (/) of CD8
16) Confidence 0.36 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 0.61 Pain Relevance 0
This difference also was observed when the number of tetramer/pentamer+CD8+ and IFN?
Positive_regulation (/) of CD8
17) Confidence 0.36 Published 2008 Journal Virol J Section Body Doc Link PMC2561024 Disease Relevance 0.90 Pain Relevance 0
Recent studies have reported that the CD94-Qa-1 system is implicated in the induction of ACAID CD8+Treg, but the functions and characteristics of CD8+CD94+T cells remain unclear.


Positive_regulation (induction) of ACAID CD8 in T cells
18) Confidence 0.35 Published 2008 Journal BMC Immunol Section Abstract Doc Link PMC2566975 Disease Relevance 0 Pain Relevance 0.05
Rs expressed on DCs are important in the induction of enhanced CD8+ T-cell responses.
Positive_regulation (induction) of CD8 in T-cell
19) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.52 Pain Relevance 0
R-specific antibody (Figure 6A), (ii) DCs are more efficiently activated by SpFr-IC than by SpFr, at least as assayed by CD40, and CD86 expression (Figure 6B), (iii) 667-complexed FrCasE-infected splenocytes are more efficient at inducing anti-FrCasE CD8+ T-cell responses than non-mAb-complexed cells both in vitro (Figure 4B) and in vivo (Figure 5) and (iv) such enhanced CD8+ T-cell responses are dependent on IC interactions with Fc?
Positive_regulation (inducing) of CD8 in T-cell
20) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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