INT189092

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Context Info
Confidence 0.76
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 56
Total Number 56
Disease Relevance 14.09
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap1) mitochondrion (Tap1) endoplasmic reticulum (Tap1)
ATPase activity (Tap1) plasma membrane (Tap1) transmembrane transport (Tap1)
Anatomy Link Frequency
spleen 4
tendon 2
nerve 1
brain 1
DCs 1
Tap1 (Mus musculus)
Pain Link Frequency Relevance Heat
ilioinguinal nerve 2 99.48 Very High Very High Very High
psoriasis 36 99.16 Very High Very High Very High
Analgesic 17 97.92 Very High Very High Very High
Glutamate receptor 45 91.68 High High
local anesthetic 16 81.92 Quite High
rheumatoid arthritis 34 81.88 Quite High
depression 14 81.20 Quite High
Ultiva 9 79.96 Quite High
Etanercept 1 71.84 Quite High
antagonist 1 71.40 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 30 100.00 Very High Very High Very High
Viral Infection 235 99.72 Very High Very High Very High
Infection 898 99.44 Very High Very High Very High
Pox Virus Infection 705 99.42 Very High Very High Very High
Psoriasis 44 99.16 Very High Very High Very High
Rupture 46 98.22 Very High Very High Very High
Tendinitis And Tenosynovitis 40 96.40 Very High Very High Very High
Depression 35 95.08 Very High Very High Very High
Vesicular Stomatitis 188 94.64 High High
Disease 69 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in VSV-specific CD8+ cells observed with VV-hTAP1,2 coinfections indicates a TAP-dependent increase in APC cross-priming and cross-presentation activity and is explained by an increase in TAP expression and peptide-transport activity in the APCs of the spleen.
Gene_expression (expression) of TAP in spleen
1) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.07 Pain Relevance 0
Human TAP1 protein was detected in splenocytes by immunoblotting (Figure 4A), and RT-PCR analysis showed that both human TAP1 and human TAP2 mRNA were present (Figure 4B).
Gene_expression (detected) of TAP1
2) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.30 Pain Relevance 0
Another well-characterized CTL epitope, from Sendai virus nucleoprotein (SV-NP), was investigated to provide further evidence that TAP over-expression can augment antiviral responses.
Gene_expression (over) of TAP
3) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.35 Pain Relevance 0
In DCs, over-expression of TAP has the additional effect of increasing the cross-presentation pathway for MHC class I, a pathway believed to be unique to these cells.
Gene_expression (over) of TAP
4) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
Human TAP1 expression in splenocytes from the mice infected with VV-hTAP1,2 was determined by SDS-PAGE and Western blot.
Gene_expression (expression) of TAP1
5) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.22 Pain Relevance 0
Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.
Gene_expression (expression) of TAP1
6) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
To reconcile the increase in peptide-transport activity observed in the translocation assays with the frequency of human TAP-positive splenocytes, we estimate that the human TAP-positive splenocytes need to express 12 to 17 times more human TAP1 mRNA than endogenous mouse TAP1.
Gene_expression (express) of TAP1
7) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
The augmentation of a specific immune response against a virus by increasing TAP expression in APCs may require that viral infection and the over-expression of TAP occur in the same cell.
Gene_expression (expression) of TAP associated with viral infection
8) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.32 Pain Relevance 0
Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.
Gene_expression (expression) of TAP1
9) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
The response was specific to the expression of TAP rather than to the VV vector alone, since coinfection with VV-PJS-5 did not increase CTL responses to VSV.
Gene_expression (expression) of TAP
10) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.32 Pain Relevance 0
The augmentation of a specific immune response against a virus by increasing TAP expression in APCs may require that viral infection and the over-expression of TAP occur in the same cell.
Gene_expression (expression) of TAP associated with viral infection
11) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.33 Pain Relevance 0
We conclude that supra-normal expression of TAP increases endogenous antigen processing (see Figure 2C) and the levels of both total and cross-presented MHC class I antigens on the surface of DCs, thereby leading to greater CTL responses in vivo.
Gene_expression (expression) of TAP
12) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
To reconcile the increase in peptide-transport activity observed in the translocation assays with the frequency of human TAP-positive splenocytes, we estimate that the human TAP-positive splenocytes need to express 12 to 17 times more human TAP1 mRNA than endogenous mouse TAP1.
Gene_expression (express) of TAP1 mRNA
13) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
Expression of TAP1 alone has been shown to stabilize TAP2 protein and TAP2 mRNA in TAP-deficient cells and could explain the effectiveness of TAP1 alone [30].
Gene_expression (Expression) of TAP1
14) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.14 Pain Relevance 0
We have shown here, in an animal model, that TAP over-expression can augment cell-mediated immunity against the cowpox virus (vaccinia), a close relative of smallpox (variola).
Gene_expression (over) of TAP associated with pox virus infection
15) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.55 Pain Relevance 0
Double staining for cell-specific antigens and human TAP1 showed that 3.0% of B cells, 2.4% of macrophages, and 1.9% of dendritic cells (DCs) were positive for human TAP1 expression (Figure 4C).
Gene_expression (expression) of TAP1 in DCs
16) Confidence 0.76 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.38 Pain Relevance 0
This was confirmed by the high expression of the human TAP gene early in the infection.
Gene_expression (expression) of TAP gene associated with infection
17) Confidence 0.66 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.10 Pain Relevance 0
Detection of human TAP expression in splenocytes.
Gene_expression (expression) of TAP
18) Confidence 0.66 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.22 Pain Relevance 0
The blots were probed for human TAP1 with rabbit anti-human TAP1 antiserum (Stressgen Biotechnologies, Victoria, British Colombia, Canada) and visualized by enhanced chemiluminescence (Amersham Biosciences, Little Chalfont, United Kingdom).


Gene_expression (probed) of TAP1
19) Confidence 0.66 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.22 Pain Relevance 0
For these reasons, we conclude that the augmentation of the CTL responses against viruses in our experiments is justified by TAP over-expression rather than by the increased efficiencies of interspecies TAP heterodimers.
Gene_expression (expression) of TAP
20) Confidence 0.66 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0

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