INT189093

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.60
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
W6/32 1
lymphocytes 1
internal 1
immune system 1
T cells 1
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 10 77.72 Quite High
Inflammation 65 74.16 Quite High
cytokine 28 68.68 Quite High
alcohol 26 50.00 Quite Low
anesthesia 9 44.08 Quite Low
ketamine 6 43.12 Quite Low
rheumatoid arthritis 54 5.00 Very Low Very Low Very Low
Arthritis 13 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 57 96.84 Very High Very High Very High
Targeted Disruption 14 95.60 Very High Very High Very High
Sprains And Strains 54 93.60 High High
Cancer 64 89.64 High High
Apoptosis 43 82.48 Quite High
Impaired Glucose Tolerance 10 77.72 Quite High
INFLAMMATION 62 74.16 Quite High
Testicular Cancer 2 73.84 Quite High
Death 22 71.44 Quite High
Pox Virus Infection 34 69.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The population coverage would be even higher, if we had also considered HLA class I alleles that bind the epitopes as strong as or stronger than the restricting HLA class I allele identified in the present study.
class I Binding (bind) of
1) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.28 Pain Relevance 0
An additional advantage of including TAP as an adjuvant is its ability to increase peptide transport of a number of immunogenic peptides simultaneously, thereby aiding in the delivery of diverse peptides for binding to most HLA (human major histocompatibility complex) class I alleles expressed in the immunized population.
class I Binding (binding) of
2) Confidence 0.36 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
To determine whether the remaining 161 peptides were indeed binders to the relevant HLA class I molecules, they were tested in a biochemical in vitro binding assay.
class I Binding (binders) of
3) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0.03
Distinct CTA can encode for different antigenic peptides that are presented to the immune system in association with various human leukocyte antigens (HLA), HLA class I or HLA class II allospecificities, eliciting both cytotoxic T lymphocytes (CTL) and humoral immune responses.
class I Binding (association) of in immune system
4) Confidence 0.36 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.82 Pain Relevance 0
In brief, using the albino Friend Virus-B type (FVB) mice, the cDNA for murine class I ADH was inserted behind mouse ?
class I Binding (cDNA) of
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 0.73 Pain Relevance 0
In brief, using the albino Friend Virus-B type (FVB) mice, the cDNA for murine class I ADH was inserted behind mouse ?
class I Binding (cDNA) of
6) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.35 Pain Relevance 0.04
W6/32 is a prototypic anti-MHC class I antibody that binds to a conformational epitope on MHCI heavy chains upon their association with ?
class I Binding (binds) of in W6/32
7) Confidence 0.35 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
MHC class I molecules bind antigens that are generated by the particular cells themselves as well as antigens from intracellular pathogens that reside in the cytoplasm; they present their antigens to CD8+ T cells.
class I Binding (bind) of in T cells
8) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0 Pain Relevance 0
Major histocompatibility complex (MHC) class I molecules are highly polymorphic cell-surface glycoproteins, which function to bind peptides for presentation to cytotoxic lymphocytes (CTLs) following microbial infection or cell transformation [1–3].
class I Binding (bind) of in lymphocytes associated with infection
9) Confidence 0.35 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.10 Pain Relevance 0
Confocal images show localization of both class1 and class2 on vessels structures (Figure 6A, B) and confirmed our finding that the two scFv classes have a distinct staining pattern, with class1 binding the more external layers and class2 the more internal layers.
class1 Binding (binding) of in internal
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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