INT189097

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 2.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Tap1) mitochondrion (Tap1) endoplasmic reticulum (Tap1)
ATPase activity (Tap1) plasma membrane (Tap1) transmembrane transport (Tap1)
Anatomy Link Frequency
spleen 4
DCs 2
Tap1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 4 40.48 Quite Low
Action potential 2 19.96 Low Low
Pain 1 13.12 Low Low
addiction 1 10.40 Low Low
Potency 34 5.00 Very Low Very Low Very Low
anesthesia 17 5.00 Very Low Very Low Very Low
adenocard 17 5.00 Very Low Very Low Very Low
isoflurane 17 5.00 Very Low Very Low Very Low
Glutamate receptor 9 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 100.00 Very High Very High Very High
Viral Infection 85 98.96 Very High Very High Very High
Infection 323 97.00 Very High Very High Very High
Vesicular Stomatitis 68 73.72 Quite High
Pox Virus Infection 255 68.36 Quite High
Death 17 67.92 Quite High
Weight Loss 51 61.76 Quite High
Communicable Diseases 34 53.20 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 34 50.96 Quite High
Severe Acute Respiratory Syndrome 17 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Double staining for cell-specific antigens and human TAP1 showed that 3.0% of B cells, 2.4% of macrophages, and 1.9% of dendritic cells (DCs) were positive for human TAP1 expression (Figure 4C).
Positive_regulation (positive) of Gene_expression (expression) of TAP1 in DCs
1) Confidence 0.68 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.39 Pain Relevance 0
Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.
Positive_regulation (Increased) of Gene_expression (expression) of TAP1
2) Confidence 0.68 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
The augmentation of a specific immune response against a virus by increasing TAP expression in APCs may require that viral infection and the over-expression of TAP occur in the same cell.
Positive_regulation (increasing) of Gene_expression (expression) of TAP associated with viral infection
3) Confidence 0.68 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.33 Pain Relevance 0
The increase in VSV-specific CD8+ cells observed with VV-hTAP1,2 coinfections indicates a TAP-dependent increase in APC cross-priming and cross-presentation activity and is explained by an increase in TAP expression and peptide-transport activity in the APCs of the spleen.
Positive_regulation (increase) of Gene_expression (expression) of TAP in spleen
4) Confidence 0.68 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.07 Pain Relevance 0
We conclude that supra-normal expression of TAP increases endogenous antigen processing (see Figure 2C) and the levels of both total and cross-presented MHC class I antigens on the surface of DCs, thereby leading to greater CTL responses in vivo.
Positive_regulation (increases) of Gene_expression (expression) of TAP
5) Confidence 0.49 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.
Positive_regulation (increased) of Gene_expression (expression) of TAP1
6) Confidence 0.49 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
In DCs, over-expression of TAP has the additional effect of increasing the cross-presentation pathway for MHC class I, a pathway believed to be unique to these cells.
Positive_regulation (over) of Gene_expression (over) of TAP
7) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
Mechanistically, the total MHC class I antigen surface expression and the cross-presentation mechanism in spleen-derived dendritic cells was augmented by over-expression of TAP.
Positive_regulation (over) of Gene_expression (expression) of TAP in spleen
8) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Abstract Doc Link PMC1323471 Disease Relevance 0.45 Pain Relevance 0
In DCs, over-expression of TAP has the additional effect of increasing the cross-presentation pathway for MHC class I, a pathway believed to be unique to these cells.
Positive_regulation (over) of Gene_expression (expression) of TAP
9) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
Contrary to expectation, we observed that increasing TAP expression in mice augments the cellular immune response to a variety of viral pathogens including VSV, SV, and VV at infectious doses that normally do not generate significant CTL activity.
Positive_regulation (increasing) of Gene_expression (expression) of TAP
10) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.25 Pain Relevance 0
In DCs, over-expression of TAP has the additional effect of increasing the cross-presentation pathway for MHC class I, a pathway believed to be unique to these cells.
Positive_regulation (expression) of Gene_expression (over) of TAP
11) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
Increased expression of mouse TAP1 appeared to be as effective as increased expression of human TAP1 and TAP2 in raising the level of MHC class I complexes (H-2Kb–SIINFEKL) on the cell surface.
Positive_regulation (effective) of Gene_expression (expression) of TAP1
12) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
In DCs, over-expression of TAP has the additional effect of increasing the cross-presentation pathway for MHC class I, a pathway believed to be unique to these cells.
Positive_regulation (expression) of Gene_expression (expression) of TAP
13) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.15 Pain Relevance 0
The increase in CTL activity in mice coinfected with VV-hTAP1,2 and with low infectious doses of VSV, SV, and VV-NP-VSV shows that this increase is dependent on the expression of TAP activity alone.
Positive_regulation (dependent) of Gene_expression (expression) of TAP
14) Confidence 0.46 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0.09 Pain Relevance 0
For these reasons, we conclude that the augmentation of the CTL responses against viruses in our experiments is justified by TAP over-expression rather than by the increased efficiencies of interspecies TAP heterodimers.
Positive_regulation (over) of Gene_expression (over) of TAP
15) Confidence 0.40 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
For these reasons, we conclude that the augmentation of the CTL responses against viruses in our experiments is justified by TAP over-expression rather than by the increased efficiencies of interspecies TAP heterodimers.
Positive_regulation (over) of Gene_expression (-) of TAP
16) Confidence 0.40 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
For these reasons, we conclude that the augmentation of the CTL responses against viruses in our experiments is justified by TAP over-expression rather than by the increased efficiencies of interspecies TAP heterodimers.
Positive_regulation (over) of Gene_expression (expression) of TAP
17) Confidence 0.40 Published 2005 Journal PLoS Pathogens Section Body Doc Link PMC1323471 Disease Relevance 0 Pain Relevance 0
In mammalian tissues, where developmental and cell-type control of regulation is more complex, the targeting of the TAP tag into the endogenous gene provides advantages over transgenic random integration or cDNA overexpression systems (Knuesel et al, 2003; Bouwmeester et al, 2004; Brajenovic et al, 2004; Drakas et al, 2005; Wang et al, 2005, 2006; Angrand et al, 2006; Burckstummer et al, 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of TAP associated with targeted disruption
18) Confidence 0.29 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2694677 Disease Relevance 0.10 Pain Relevance 0

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