INT189130

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 7.64
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dendrite 1
vertebral column 1
spinal cord 1
musculoskeletal system 1
body 1
AIS (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 280 99.90 Very High Very High Very High
Inflammation 4 98.24 Very High Very High Very High
sodium channel 10 96.52 Very High Very High Very High
Pain 34 78.00 Quite High
syringomyelia 33 76.40 Quite High
backache 4 75.52 Quite High
Arthritis 2 71.20 Quite High
agonist 6 61.76 Quite High
Central nervous system 9 50.00 Quite Low
Nav1.2 11 43.20 Quite Low
Disease Link Frequency Relevance Heat
Scoliosis 1145 100.00 Very High Very High Very High
Cancer 82 100.00 Very High Very High Very High
Recurrence 35 99.92 Very High Very High Very High
Breast Cancer 148 99.88 Very High Very High Very High
Heart Disease 3 99.44 Very High Very High Very High
Inflammatory Breast Neoplasms 1 98.24 Very High Very High Very High
Cardiovascular Disease 24 97.80 Very High Very High Very High
Rare Diseases 1 97.44 Very High Very High Very High
Metastasis 6 96.80 Very High Very High Very High
Malignant Neoplastic Disease 9 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of AIs on the musculoskeletal system
Regulation (Effects) of AIs in musculoskeletal system
1) Confidence 0.39 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 1.04 Pain Relevance 0.11
Effects of AIs on bone metabolism
Regulation (Effects) of AIs
2) Confidence 0.39 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682397 Disease Relevance 0.60 Pain Relevance 0.03
Although AIS is the most common orthopedic disorder affecting children the previous problems noted also include state mandates and conflicting recommendations from the research record.
Regulation (affecting) of AIS associated with scoliosis
3) Confidence 0.38 Published 2005 Journal Chiropr Osteopat Section Body Doc Link PMC1325030 Disease Relevance 0.42 Pain Relevance 0
AIS as a motor control problem
Regulation (control) of AIS associated with scoliosis
4) Confidence 0.35 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.65 Pain Relevance 0.03
The signs and symptoms of AIS obviously are not significantly influenced by surgery [24].
Neg (not) Regulation (influenced) of AIS associated with scoliosis
5) Confidence 0.30 Published 2008 Journal Scoliosis Section Body Doc Link PMC2525632 Disease Relevance 0.82 Pain Relevance 0
Our study suggests the presence of tethering and increased tension along the longitudinal axis of spinal cord results in morphological changes of cross-sectional shape and relative position of the cord – an observation which is particularly obvious in the apical region In conclusion, there is indirect evidence that the cord in AIS is "abnormal" and we hypothesize that both vertebral column and spinal cord are affected in AIS (ie.'
Regulation (affected) of AIS in spinal cord associated with scoliosis and spinal cord
6) Confidence 0.21 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.77 Pain Relevance 0.24
Exclusion criteria included previous exposure to AIs, uncontrolled endocrine or cardiac disease, bilateral or inflammatory breast cancer, distant metastasis, and other malignant disease.
Regulation (uncontrolled) of AIs associated with malignant neoplastic disease, inflammation, heart disease, disease and metastasis
7) Confidence 0.20 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 1.06 Pain Relevance 0.05
Our study suggests the presence of tethering and increased tension along the longitudinal axis of spinal cord results in morphological changes of cross-sectional shape and relative position of the cord – an observation which is particularly obvious in the apical region In conclusion, there is indirect evidence that the cord in AIS is "abnormal" and we hypothesize that both vertebral column and spinal cord are affected in AIS (ie.'
Regulation (affected) of AIS in vertebral column associated with scoliosis and spinal cord
8) Confidence 0.07 Published 2008 Journal Scoliosis Section Body Doc Link PMC2474583 Disease Relevance 0.77 Pain Relevance 0.24
We also assumed that neither the hazard rate for relapse on AIs nor the tumor characteristics were affected by metabolizer status and CYP2D6 genotype.


Neg (neither) Regulation (affected) of AIs associated with cancer and recurrence
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004945 Disease Relevance 0.45 Pain Relevance 0
The comparable role of tamoxifen with AIs in women with breast cancer who presented with wild-type CYP2D6 is successfully replicated using ATAC survival data
Regulation (role) of AIs associated with breast cancer
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004945 Disease Relevance 0.10 Pain Relevance 0
AIS is a chronic condition that affects the body configuration of the adolescent leading to certain alterations in lifestyle as a consequence.
Regulation (affects) of AIS in body associated with scoliosis
11) Confidence 0.02 Published 2006 Journal Scoliosis Section Body Doc Link PMC1481574 Disease Relevance 0.95 Pain Relevance 0.20
In case (Fig. 4G), the rather small activating function values in the AIS are, however, still more powerful than the higher values in the dendrite with its low sodium channel density resulting in distant spike initiation, that is more than 400 ?
Regulation (values) of AIS in dendrite associated with sodium channel
12) Confidence 0.01 Published 2010 Journal Neuroscience Section Body Doc Link PMC2954315 Disease Relevance 0 Pain Relevance 0.09

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