INT189142

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.29
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) plasma membrane (MTNR1B)
cytoplasm (IL12A) signal transducer activity (MTNR1B)
Anatomy Link Frequency
monocytes 2
MTNR1B (Homo sapiens)
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 40 89.96 High High
Inflammation 8 11.72 Low Low
Opioid 6 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Enkephalin 4 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
opiate 2 5.00 Very Low Very Low Very Low
Serotonin 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 68 89.96 High High
Affective Disorder 2 66.88 Quite High
Cancer 12 51.44 Quite High
Disease 10 34.08 Quite Low
Apoptosis 6 23.28 Low Low
INFLAMMATION 8 11.72 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low
Immunodeficiency 6 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low
Communicable Diseases 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin also increases IL-12 production by monocytes [105].
Melatonin Positive_regulation (increases) of Gene_expression (production) of IL-12 in monocytes
1) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.05 Pain Relevance 0.21
Production of IL-2, IL-6 and IL-12 is stimulated by melatonin.
melatonin Positive_regulation (stimulated) of Gene_expression (Production) of IL-12
2) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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