INT189146

Context Info Confidence 0.01 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.22

plasma membrane (MTNR1B, TNF) signal transduction (TNF) extracellular space (TNF) extracellular region (TNF) intracellular (TNF) extracellular matrix organization (TNF)

Anatomy Link Frequency monocytes 2 MTNR1B (Homo sapiens) TNF (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 20 94.04 Inflammation 4 5.00 Opioid 3 5.00 chemokine 2 5.00 Enkephalin 2 5.00 agonist 1 5.00 opiate 1 5.00 Serotonin 1 5.00 antagonist 1 5.00

Disease Link Frequency Relevance Heat Cancer 6 55.52 Disease 5 38.16 Apoptosis 3 19.20 Aging 34 5.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 5.00 INFLAMMATION 4 5.00 Immunodeficiency 3 5.00 Stress 3 5.00 Communicable Diseases 2 5.00 Immunization 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Melatonin, by. activating monocytes [105], increases the production of IL-1, IL-6, TNF-alpha and ROS.

Melatonin Positive_regulation (increases) of Gene_expression (production) of TNF-alpha in monocytes

1) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.06 Pain Relevance 0.22

General Comments

This test has worked.