INT189151

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.35
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
plasma membrane (MTNR1B) signal transducer activity (MTNR1B)
Anatomy Link Frequency
monocytes 2
mononuclear cells 2
MTNR1B (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 98.20 Very High Very High Very High
Inflammation 12 11.72 Low Low
Opioid 9 5.00 Very Low Very Low Very Low
chemokine 6 5.00 Very Low Very Low Very Low
Enkephalin 6 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
opiate 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 102 89.96 High High
Affective Disorder 3 66.88 Quite High
Cancer 18 59.68 Quite High
Disease 15 42.32 Quite Low
Apoptosis 9 18.32 Low Low
INFLAMMATION 12 11.72 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low
Immunodeficiency 9 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Communicable Diseases 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin enhances the production of IL2, IFN-gamma and IL-6 by cultured human mononuclear cells [101].
Melatonin Positive_regulation (enhances) of Gene_expression (production) of IL-6 in mononuclear cells
1) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.06 Pain Relevance 0.23
Melatonin, by. activating monocytes [105], increases the production of IL-1, IL-6, TNF-alpha and ROS.
Melatonin Positive_regulation (increases) of Gene_expression (production) of IL-6 in monocytes
2) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.06 Pain Relevance 0.22
Production of IL-2, IL-6 and IL-12 is stimulated by melatonin.
melatonin Positive_regulation (stimulated) of Gene_expression (Production) of IL-6
3) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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