INT189169

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 3.71
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTNR1B) signal transducer activity (MTNR1B)
Anatomy Link Frequency
eye 2
NK cell 2
MT2 1
monocyte 1
lymphocytes 1
MTNR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 140 99.88 Very High Very High Very High
Central nervous system 4 97.32 Very High Very High Very High
antidepressant 34 96.36 Very High Very High Very High
depression 46 91.00 High High
Opioid 21 78.40 Quite High
Angina 1 71.12 Quite High
sNRI 4 21.76 Low Low
Serotonin 13 19.96 Low Low
sSRI 7 15.04 Low Low
monoamine 4 12.84 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 44 100.00 Very High Very High Very High
Cancer 43 98.16 Very High Very High Very High
Aging 238 94.08 High High
Immunodeficiency 21 92.96 High High
Apoptosis 21 91.92 High High
Depression 54 91.00 High High
Weight Loss 7 86.64 High High
Frailty 7 85.72 High High
Critical Illness 6 84.88 Quite High
Disease 48 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, substantial advances have been made in the past few years, with an increase in confirmed type 2 diabetes susceptibility loci from 3 genes (PPARG, KCNJ11, and TCF7L2) to almost 20 (with newly identified variants in the following genes: ADAMTS9, CDKAL1, CDKN2A/B, CAMK1D, FTO, HHEX/IDE, HNF1B, IGF2BP2, JAZF1, MTNR1B, NOTCH2, SLC30A8, THADA, TSPAN8, and WFS1) (14–17).
Positive_regulation (increase) of MTNR1B associated with diabetes mellitus
1) Confidence 0.16 Published 2010 Journal American Journal of Epidemiology Section Body Doc Link PMC2834889 Disease Relevance 1.25 Pain Relevance 0.07
Key messages

• Subjects had poorer perceived sleep quality, more light sleep, longer REM latency, and less REM sleep when exposed to simulated ICU noise and light. • Nocturnal melatonin and cortisol secretion levels differed significantly by experimental condition. • Use of earplugs and eye masks resulted in more REM time, shorter REM latency, less arousal and an elevation of nocturnal melatonin levels.


Positive_regulation (elevation) of melatonin in eye
2) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2887188 Disease Relevance 0.22 Pain Relevance 0
In summary, our results found that use of earplugs and eye masks in subjects not only improves subjective sleep quality, but also increases the amount of REM sleep and nocturnal melatonin levels in a simulated ICU environment.
Positive_regulation (increases) of melatonin in eye
3) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2887188 Disease Relevance 0.24 Pain Relevance 0
Melatonin secretion underlies strict circadian rhythms1 and is regulated via the cAMP signal transduction cascade.2 A variety of animal studies and clinical trials in depressed patients suggest that agomelatine, a synthetic melatonergic MT1 and MT2 receptor agonist4 with 5-HT2C receptor antagonistic properties5 within the CNS, has activating and antidepressant effects.6
Positive_regulation (melatonergic) of MT2 receptor in MT2 associated with antidepressant and central nervous system
4) Confidence 0.05 Published 2010 Journal Core evidence Section Body Doc Link PMC2899775 Disease Relevance 0.24 Pain Relevance 0.50
This protective effect of melatonin on thymocytes was attributed to its antiapoptotic action.
Positive_regulation (attributed) of melatonin in thymocytes
5) Confidence 0.02 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.54 Pain Relevance 0
T helper cells contain melatonin receptors that presumably mediate melatonin action in releasing cytokines [101-103].


Positive_regulation (mediate) of melatonin associated with cytokine
6) Confidence 0.02 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.12 Pain Relevance 0.23
Besides its stimulatory action on the production of several cytokines that regulate immune function, melatonin's immunoenhancing properties have been attributed to a direct action on the immunocompetent cells (e.g. granulocyte-macrophage cells, NK cells and lymphocytes).
Positive_regulation (attributed) of melatonin in lymphocytes associated with cytokine
7) Confidence 0.02 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.25 Pain Relevance 0.12
Circulating melatonin decreases with age and in recent years much interest has been focused on its immunomodulatory effect.
Positive_regulation (Circulating) of melatonin
8) Confidence 0.02 Published 2005 Journal Immun Ageing Section Abstract Doc Link PMC1325257 Disease Relevance 0.38 Pain Relevance 0.15
The action of melatonin on monocyte production can be partly due to its direct action on melatonin receptors or may be due to an increase of monocyte sensitivity to stimulants like IL-3, IL-4, IL-6 or GM-colony stimulating factor (GM-CSF) [88-90].
Positive_regulation (action) of melatonin in monocyte
9) Confidence 0.02 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.10 Pain Relevance 0.19
IL-2, IL-6, IL-12 and IFN-gamma have all been suggested as the possible cytokines that mediate melatonin-induced increase of NK cell number [90].
Spec (possible) Positive_regulation (mediate) of melatonin in NK cell associated with cytokine
10) Confidence 0.02 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.13 Pain Relevance 0.22
Besides its stimulatory action on the production of several cytokines that regulate immune function, melatonin's immunoenhancing properties have been attributed to a direct action on the immunocompetent cells (e.g. granulocyte-macrophage cells, NK cells and lymphocytes).
Positive_regulation (attributed) of melatonin in NK cells associated with cytokine
11) Confidence 0.01 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.25 Pain Relevance 0.12

General Comments

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