INT189176

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.93
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
keratinocytes 2
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 52 100.00 Very High Very High Very High
Inflammation 51 97.04 Very High Very High Very High
Inflammatory response 6 86.40 High High
chemokine 8 64.32 Quite High
agonist 10 58.68 Quite High
opiate 1 38.92 Quite Low
psoriasis 19 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
pruritus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fungal Infection 2 99.64 Very High Very High Very High
Viral Infection 4 99.10 Very High Very High Very High
Bacterial Infection 3 98.74 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 77 97.76 Very High Very High Very High
INFLAMMATION 54 97.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 30 95.48 Very High Very High Very High
Infection 72 91.20 High High
Leishmaniasis 68 86.52 High High
Parasitic Infection 15 84.36 Quite High
Hypersensitivity 4 73.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides the release of proinflammatory Th-1 cytokines, such as IFN-gamma and IL2 administration of melatonin to antigen-primed mice increased the production of IL10, indicating that melatonin can also activate anti-inflammatory Th-2-like immune responses in certain circumstances [128].
Positive_regulation (increased) of Localization (release) of Th-1 associated with inflammation and cytokine
1) Confidence 0.23 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.54 Pain Relevance 0.13
For example, they were found to mature and initiate a Th1 response in the presence of keratinocytes that secreted IFN?
Positive_regulation (initiate) of Localization (response) of Th1 in keratinocytes
2) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.07 Pain Relevance 0.20
Secondly, imiquimod could mediate a better anti-Leishmania Th1 immune response that would result in the production of IFN-?
Positive_regulation (mediate) of Localization (response) of Th1
3) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710502 Disease Relevance 0.48 Pain Relevance 0
Secondly, imiquimod could mediate a better anti-Leishmania Th1 immune response that would result in the production of IFN-?
Positive_regulation (result) of Localization (response) of Th1
4) Confidence 0.08 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710502 Disease Relevance 0.48 Pain Relevance 0
Most cases of IRD are associated with chronic bacterial infections, viral infections and deep fungal infections, which typically trigger immunopathology via cell-mediated T-helper type 1 (TH1) cytokine-secreting immune responses (8,10,53).
Positive_regulation (trigger) of Localization (secreting) of TH1 associated with fungal infection, immune reconstitution inflammatory syndrome, viral infection, bacterial infection and cytokine
5) Confidence 0.04 Published 2006 Journal Parasite Immunology Section Body Doc Link PMC1636681 Disease Relevance 1.38 Pain Relevance 0.09

General Comments

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