INT189177

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Context Info
Confidence 0.11
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 3.77
Pain Relevance 6.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
neurons 12
neuronal 2
nerve 2
dorsal horn 2
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 287 100.00 Very High Very High Very High
Eae 17 100.00 Very High Very High Very High
ketamine 94 99.84 Very High Very High Very High
allodynia 172 99.20 Very High Very High Very High
spinal dorsal horn 47 99.20 Very High Very High Very High
Cold hyperalgesia 9 99.16 Very High Very High Very High
intrathecal 59 95.88 Very High Very High Very High
Pain 140 95.72 Very High Very High Very High
withdrawal 42 93.76 High High
Analgesic 42 92.48 High High
Disease Link Frequency Relevance Heat
Injury 81 100.00 Very High Very High Very High
Neuropathic Pain 441 99.20 Very High Very High Very High
Hyperalgesia 71 99.16 Very High Very High Very High
Nervous System Injury 144 99.00 Very High Very High Very High
Nociception 77 93.52 High High
Neuralgia 1 77.76 Quite High
Herpes Simplex Virus Infection 1 76.64 Quite High
Pain 123 72.52 Quite High
Spinal Injuries 2 65.32 Quite High
INFLAMMATION 17 57.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly we did not detect cold hyperalgesia in the SNL model at -5°C, even though an increase in the percentage of cold responsive neurons in the uninjured L4 DRG following SNL has been reported [20].
Positive_regulation (increase) of Gene_expression (following) of SNL in neurons associated with hyperalgesia, cold hyperalgesia and eae
1) Confidence 0.11 Published 2005 Journal Mol Pain Section Body Doc Link PMC1325266 Disease Relevance 1.23 Pain Relevance 1.23
Inhibition of ASO on SNL-induced Fos expression occured right after the nerve injury (at 2 h after SNL).
Positive_regulation (on) of Gene_expression (expression) of SNL-induced in nerve associated with nervous system injury and spinal nerve ligature
2) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.32 Pain Relevance 1.03
SNL enhanced Fos and GFAP expression in the ipsilateral spinal dorsal horn
Positive_regulation (enhanced) of Gene_expression (expression) of SNL in dorsal horn associated with spinal dorsal horn and spinal nerve ligature
3) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.49 Pain Relevance 0.93
C-fos ASO treatment suppressed SNL-induced neuronal and astrocytic activations in different manners
Positive_regulation (activations) of Gene_expression (neuronal) of SNL-induced in neuronal associated with spinal nerve ligature
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.91
Intriguingly, SNL-induced enhancements of GFAP- and Iba 1-IR were markedly suppressed in Cav2.2-/- mice (Figure 2Cii, 2Ciii, 2D and 2E).
Positive_regulation (enhancements) of Gene_expression (suppressed) of SNL
5) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.51 Pain Relevance 0.34
If the SNL injury down regulates some of the gene expression including CK1?
Positive_regulation (including) of Gene_expression (injury) of SNL associated with injury
6) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.37
Ketamine or LAA attenuated SNL-induced mechanical allodynia individually in dose-dependent manners
Positive_regulation (attenuated) of Gene_expression (attenuated) of SNL associated with allodynia, ketamine and spinal nerve ligature
7) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.32 Pain Relevance 1.31
M) for 20 min did not block SNAP-induced KATP channel activation in either SS neurons (NPo 10 min after SNAP = 0.14 ± 0.17; n = 5; p = 1.0 vs. control) or SNL neurons (NPo 10 min after SNAP = 0.26 ± 0.19; n = 6; p = 1.0 vs. control; Figure 5A, B).
Positive_regulation (after) of Gene_expression (neurons) of SNL in neurons
8) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
M) for 20 min failed to inhibit SNAP-induced KATP channel activation in both SS neurons (NPo 10 min after SNAP = 0.25 ± 0.09; n = 6; p = 1.0 vs. control) and SNL neurons (NPo 10 min after SNAP = 0.27 ± 0.16; n = 6; p = 1.0 vs. control; Figure 5A, B).
Positive_regulation (after) of Gene_expression (neurons) of SNL in neurons
9) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
M) for 20 min failed to inhibit SNAP-induced KATP channel activation in both SS neurons (NPo 10 min after SNAP = 0.25 ± 0.09; n = 6; p = 1.0 vs. control) and SNL neurons (NPo 10 min after SNAP = 0.27 ± 0.16; n = 6; p = 1.0 vs. control; Figure 5A, B).
Positive_regulation (activation) of Gene_expression (neurons) of SNL in neurons
10) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
M) for 20 min did not block SNAP-induced KATP channel activation in either SS neurons (NPo 10 min after SNAP = 0.14 ± 0.17; n = 5; p = 1.0 vs. control) or SNL neurons (NPo 10 min after SNAP = 0.26 ± 0.19; n = 6; p = 1.0 vs. control; Figure 5A, B).
Positive_regulation (activation) of Gene_expression (neurons) of SNL in neurons
11) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0
M) for 20 min failed to inhibit SNAP-induced KATP channel activation in both SS neurons (NPo 10 min after SNAP = 0.25 ± 0.09; n = 6; p = 1.0 vs. control) and SNL neurons (NPo 10 min after SNAP = 0.27 ± 0.16; n = 6; p = 1.0 vs. control; Figure 5A, B).
Positive_regulation (after) of Gene_expression (neurons) of SNL in neurons
12) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0 Pain Relevance 0

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