INT189182

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 4.45
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Rpsa) structural constituent of ribosome (Rpsa) ribosome (Rpsa)
plasma membrane (Rpsa) nucleus (Rpsa) intracellular (Rpsa)
Anatomy Link Frequency
macrophages 3
myeloid cells 1
Ridge 1
Rpsa (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 193 99.46 Very High Very High Very High
cytokine 178 95.40 Very High Very High Very High
Inflammatory response 12 93.08 High High
rheumatoid arthritis 110 91.36 High High
agonist 33 86.84 High High
Inflammation 65 83.36 Quite High
Demyelination 16 76.08 Quite High
chemokine 20 75.52 Quite High
iatrogenic 1 69.92 Quite High
Multiple sclerosis 8 69.68 Quite High
Disease Link Frequency Relevance Heat
Arthritis 225 99.46 Very High Very High Very High
Disease 157 94.76 High High
INFLAMMATION 75 92.68 High High
Rheumatoid Arthritis 110 91.36 High High
Sprains And Strains 6 89.84 High High
Systemic Lupus Erythematosus 8 83.28 Quite High
Multiple Sclerosis 42 77.12 Quite High
Demyelinating Disease 16 76.08 Quite High
Adhesions 8 76.04 Quite High
Cancer 18 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RNA was isolated using the RNeasy protect mini kit (QIAGEN) and cDNA transcribed using the reverse transcription system (Promega). p40 gene expression was determined by real-time PCR using predesigned TaqMan primers and probe (Applied Biosystems) by the comparative method of relative quantitation.
Gene_expression (expression) of p40
1) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.06 Pain Relevance 0.10
has been reported to decrease p40 expression in human macrophages (18).
Gene_expression (expression) of p40 in macrophages
2) Confidence 0.37 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 1.42 Pain Relevance 0.32
selectively inhibits p40 expression in human and mouse myeloid cells in an IL-10–independent manner (18, 19).
Gene_expression (expression) of p40 in myeloid cells
3) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.68 Pain Relevance 0.28
To quantify p40 expression without any form of manipulation in vitro, mRNA was extracted from LN cells immediately postmortem and analyzed by real-time PCR.
Gene_expression (expression) of p40
4) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.05 Pain Relevance 0.05
Next, we addressed the question of whether p40 expression was elevated in vivo in the absence of signaling via the p55 TNFR.
Spec (whether) Gene_expression (expression) of p40
5) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0 Pain Relevance 0.05
Treatment of macrophages with rTNF also inhibited p40 production in vitro.
Gene_expression (production) of p40 in macrophages
6) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2571924 Disease Relevance 0.84 Pain Relevance 0.27
The maximum inhibition of p40 production by LPS-stimulated macrophages was ?
Gene_expression (production) of p40 in macrophages
7) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571924 Disease Relevance 0.06 Pain Relevance 0.07
These findings indicate that at least one of the ways in which TNF regulates Th1/Th17 responses in arthritis is by down-regulating the expression of p40.
Gene_expression (expression) of p40 associated with arthritis
8) Confidence 0.29 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2571924 Disease Relevance 0.80 Pain Relevance 0.26
and p35 subunits, and IL-23 is composed of the same p40 subunit together with a
Gene_expression (composed) of p40
9) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442897 Disease Relevance 0.45 Pain Relevance 0.19
To identify functional allelic series' in smaller genes, or in a small discrete region of a gene, it would be advantageous to proportionately expand the size of the CMMB (e.g., a bank of 10,000 mice would yield one functional change for any 356-bp amplicon).
Gene_expression (change) of functional
10) Confidence 0.08 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0 Pain Relevance 0
Assuming that all missense mutations we identified have the potential to produce a functional protein change, our estimate of functional mutation frequency in the Oak Ridge CMMB is 1 in 2.46 Mbp.
Gene_expression (produce) of functional in Ridge
11) Confidence 0.08 Published 2005 Journal BMC Genomics Section Body Doc Link PMC1325271 Disease Relevance 0.09 Pain Relevance 0
It is known from other studies that the p40 and p35 subunits of IL-12 can be regulated independently [64]; lack of coordinated synthesis may help to explain why ATP?
Gene_expression (subunits) of p40
12) Confidence 0.07 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.19

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