INT18920

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 24
Total Number 27
Disease Relevance 9.43
Pain Relevance 3.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Egf) plasma membrane (Egf)
Anatomy Link Frequency
sensory nerves 2
plasma 1
margin 1
HGF 1
salivary glands 1
Egf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 112 100.00 Very High Very High Very High
Opioid 6 99.80 Very High Very High Very High
qutenza 22 99.50 Very High Very High Very High
agonist 81 98.32 Very High Very High Very High
Inflammation 117 96.84 Very High Very High Very High
Hyperalgesia 42 95.20 Very High Very High Very High
Dismenorea 4 95.00 High High
narcan 2 91.60 High High
Pain 44 89.76 High High
cINOD 4 89.20 High High
Disease Link Frequency Relevance Heat
Ulcers 124 100.00 Very High Very High Very High
Seronegative Spondarthritis 96 100.00 Very High Very High Very High
Salivary Gland Disease 9 100.00 Very High Very High Very High
Rheumatoid Arthritis 101 99.84 Very High Very High Very High
Stress 173 99.16 Very High Very High Very High
Colon Cancer 9 98.96 Very High Very High Very High
Adhesions 21 97.56 Very High Very High Very High
INFLAMMATION 122 96.84 Very High Very High Very High
Hyperalgesia 42 95.20 Very High Very High Very High
Dysmenorrhea 4 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Epidermal growth factor (EGF) interacts with prostaglandins and NO in many biological systems.
EGF Binding (interacts) of
1) Confidence 0.48 Published 2003 Journal Reproduction Section Abstract Doc Link 14525528 Disease Relevance 0.09 Pain Relevance 0.09
Epidermal growth factor (EGF) interacts with prostaglandins and NO in many biological systems.
Epidermal growth factor Binding (interacts) of
2) Confidence 0.48 Published 2003 Journal Reproduction Section Abstract Doc Link 14525528 Disease Relevance 0.10 Pain Relevance 0.10
We conclude that EGF, sensory nerves, and NO play an important role in the healing of gastric mucosa from lesions induced by stress and that sensory nerves and NO appear to interact with EGF in the mechanism of mucosal recovery from stress lesions.
EGF Binding (interact) of in sensory nerves associated with stress
3) Confidence 0.48 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.79 Pain Relevance 0.37
Capsaicin-sensitive afferents and EGF contained in the salivary glands may interact in the regulation of the gastric acid secretion.
EGF Binding (interact) of in salivary glands associated with qutenza and salivary gland disease
4) Confidence 0.48 Published 1991 Journal Life Sci. Section Abstract Doc Link 1990233 Disease Relevance 0.10 Pain Relevance 0.46
Epidermal growth factor (EGF) is a potent mitogen implicated in gastroprotection and ulcer healing, but its possible interaction with nitric oxide (NO) and sensory nerves on healing after acute gastric damage has not been assessed.
EGF Neg (NO) Binding (interaction) of in sensory nerves associated with ulcers
5) Confidence 0.37 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.34 Pain Relevance 0.24
The present results suggest a novel multiple interaction between estrogen and two probably paracrine hormones, EGF and opioid peptide, in the regulation of growth and development of the uterus.
EGF Binding (interaction) of in uterus associated with opioid
6) Confidence 0.36 Published 2000 Journal J. Endocrinol. Invest. Section Abstract Doc Link 11021765 Disease Relevance 0 Pain Relevance 0.22
Growth factors, especially epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) are crucial in the regulation of the reconstruction of damaged mucosal structures.
EGF Binding (crucial) of
7) Confidence 0.30 Published 1997 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 9361169 Disease Relevance 0.52 Pain Relevance 0.09
No evidence of a haplotype association with PsA for EGF markers (rs11568943 and rs2237051) was observed.
EGF Binding (association) of associated with arthritis
8) Confidence 0.30 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1781940 Disease Relevance 0.80 Pain Relevance 0.27
For the two EGF SNPs, there was no evidence of association for either rs2237051 or rs11568943 in PsA.
EGF Binding (association) of associated with arthritis
9) Confidence 0.30 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1781940 Disease Relevance 0.29 Pain Relevance 0.14
Since the stimulus for increased epithelial cell proliferation in the mucosa of ulcer margin is most likely initiated by EGF and/or TGF-?
EGF Spec (likely) Binding (initiated) of in margin associated with ulcers
10) Confidence 0.29 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386523 Disease Relevance 0.85 Pain Relevance 0
EGF binds to the EGF receptor to initiate signal transduction through multiple downstream signal mediators.
EGF Binding (binds) of
11) Confidence 0.29 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.10 Pain Relevance 0.11
Relative urinary EGF concentrations were expressed as the ratio of EGF to creatinine (ng/mL creatinine).
EGF Binding (ratio) of
12) Confidence 0.29 Published 1996 Journal J. Endourol. Section Abstract Doc Link 8972784 Disease Relevance 0 Pain Relevance 0.09
Thus, apparently EGF does initiate signalling in DRG neurons but does not initiate phosphorylation of Erk1/2.


EGF Neg (not) Binding (initiate) of in neurons
13) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.47 Pain Relevance 0.23
What is clear from our analysis is that the receptor tyrosine kinase induced signalling cascade toward Erk1/2 is activated fundamentally differently if initiated by EGF versus NGF and even GDNF.
EGF Binding (initiated) of
14) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.31 Pain Relevance 0.18
QuAM elucidates these NGF/GDNF and EGF signalling differences and explains thereby the contrary behavior of these in inflammation physiological relevant growth factors.
EGF Binding (elucidates) of associated with inflammation
15) Confidence 0.22 Published 2010 Journal Mol Pain Section Body Doc Link PMC3023724 Disease Relevance 0.59 Pain Relevance 0.48
Among these, the lung growth most resembling to the result obtained by RA was achieved by using keratinocyte growth factor and epidermal growth factor.
epidermal growth factor Binding (using) of in lung associated with rheumatoid arthritis
16) Confidence 0.21 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2459181 Disease Relevance 0.35 Pain Relevance 0
precursor can be expressed as a plasma membrane-anchored polypeptide on the surface of cells and bind to EGF receptors on adjacent cells, in this way inducing both cell adhesion and cell division (79).
EGF Binding (bind) of in plasma associated with adhesions
17) Confidence 0.19 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.26 Pain Relevance 0
For example, heparin-binding EGF (HB-EGF) and TGF-?
EGF Binding (binding) of
18) Confidence 0.17 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
For example, heparin-binding EGF (HB-EGF) and TGF-?
EGF Binding (binding) of
19) Confidence 0.17 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.05
as well as by agents that bind to receptor tyrosine kinases like EGF and HGF [6,7,8], also suggesting roles of Gi.
EGF Binding (bind) of in HGF
20) Confidence 0.15 Published 2001 Journal BMC Cell Biol Section Body Doc Link PMC37242 Disease Relevance 0.07 Pain Relevance 0

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