INT189200

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Context Info
Confidence 0.03
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.90
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (CA2, ITPR3) nucleoplasm (ITPR3) small molecule metabolic process (ITPR3)
lyase activity (CA2) endoplasmic reticulum (ITPR3) transmembrane transport (ITPR3)
Anatomy Link Frequency
reticulum 2
plasma 1
CA2 (Homo sapiens)
ITPR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 5 94.04 High High
agonist 5 92.84 High High
cva 59 79.40 Quite High
cytokine 1 66.00 Quite High
substance P 4 32.24 Quite Low
bradykinin 1 31.64 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 7 96.60 Very High Very High Very High
Disease 21 95.84 Very High Very High Very High
Alzheimer's Dementia 14 94.52 High High
Cv General 3 Under Development 57 79.40 Quite High
Spasticity 8 75.36 Quite High
Disorder Of Lipid Metabolism 5 69.52 Quite High
Syndrome 39 67.60 Quite High
Cerebral Amyloid Angiopathy 11 67.20 Quite High
Coronary Vasospasm 7 62.40 Quite High
Amyloidosis 9 62.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IP3 then binds to its receptor on the membrane of the sarcoplasmic reticulum (SR) to mobilize stored calcium irons (Ca2+) into the cytosol.
Ca2 Binding (binds) of IP3 in reticulum
1) Confidence 0.03 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2801457 Disease Relevance 0.42 Pain Relevance 0.23
SOCE

In neutrophils, changes in [Ca2+]c are often associated with InsP3-R-mediated, rapid Ca2+ release of intracellular stores followed by SOCE as a result of the activation of channels in the plasma membrane [2, 41, 42] (Fig. 1).

Ca2 Binding (associated) of InsP3 in plasma
2) Confidence 0.02 Published 2008 Journal J Leukoc Biol Section Body Doc Link PMC2567897 Disease Relevance 0.41 Pain Relevance 0.03
It is a high capacity, low affinity calcium (Ca2+) storage protein that complexes to the inositol 1,4,5-trisphosphate receptor (InsP3R) in the endoplasmic reticulum.
Ca2 Binding (complexes) of InsP3R in reticulum
3) Confidence 0.00 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.08 Pain Relevance 0

General Comments

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