INT189226

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 8
Disease Relevance 7.10
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
plasma 3
cleavage 2
extracellular matrix 1
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 164 99.12 Very High Very High Very High
rheumatoid arthritis 222 99.04 Very High Very High Very High
cva 10 90.08 High High
Inflammatory mediators 18 71.44 Quite High
Central nervous system 32 58.16 Quite High
Arthritis 6 12.60 Low Low
Fibrositis 48 5.00 Very Low Very Low Very Low
methotrexate 42 5.00 Very Low Very Low Very Low
Pain 24 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 176 99.12 Very High Very High Very High
Rheumatoid Arthritis 222 99.04 Very High Very High Very High
Amyloidosis 18 98.36 Very High Very High Very High
Apoptosis 12 98.20 Very High Very High Very High
Chronic Fatigue Syndrome 368 95.88 Very High Very High Very High
Syndrome 78 95.40 Very High Very High Very High
Cerebral Amyloid Angiopathy 22 95.00 High High
Alzheimer's Dementia 40 93.52 High High
Dementia 4 90.56 High High
Hemorrhage 6 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, MMPs, considered the major enzymes responsible for the extracellular matrix degradation, cleave pGSN in vitro [33,35] and are elevated during inflammation.
Protein_catabolism (cleave) of pGSN in extracellular matrix associated with inflammation
1) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.34 Pain Relevance 0.17
However, the evaluation of plasma and SF for evidence of proteolytic fragments of pGSN revealed no cleavage products of pGSN detectable by SDS-PAGE after immunoblotting (Figure 3c).


Protein_catabolism (cleavage) of pGSN in plasma
2) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.39 Pain Relevance 0.20
It is possible that pGSN is cleaved by MMPs in vivo during RA and that this cleavage contributes to lower levels being detected.
Protein_catabolism (cleaved) of pGSN in cleavage associated with rheumatoid arthritis
3) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.34 Pain Relevance 0.17
Human recombinant pGSN as well as pGSN in plasma is cleaved in vitro upon addition of cMMP-3 [33].
Protein_catabolism (cleaved) of pGSN in plasma
4) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.58 Pain Relevance 0.29
In vitro, pGSN can be cleaved by MMPs into fragments of 42 to 46 kDa (at Asn416-Val417, Ser51-Met52, and Ala435-Gln436) [33,35].
Protein_catabolism (cleaved) of pGSN
5) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.67 Pain Relevance 0.33
Human recombinant pGSN as well as pGSN in plasma is cleaved in vitro upon addition of cMMP-3 [33].
Protein_catabolism (cleaved) of pGSN in plasma
6) Confidence 0.54 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.58 Pain Relevance 0.29
Gelsolin cleaved by capsase-3 leads to the "blebbing" during apoptosis.
Protein_catabolism (cleaved) of Gelsolin associated with apoptosis
7) Confidence 0.26 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.09 Pain Relevance 0.14
The proteases responsible for the gelsolin cleavage that permit the change in secondary structure are unknown.
Protein_catabolism (cleavage) of gelsolin in cleavage
8) Confidence 0.23 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 2.11 Pain Relevance 0.11

General Comments

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