INT189228

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.89
Pain Relevance 0.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (KRT16) cytoskeleton organization (KRT16)
Anatomy Link Frequency
keratinocytes 3
skin 1
KRT16 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 51 98.76 Very High Very High Very High
cytokine 19 97.54 Very High Very High Very High
Central nervous system 16 96.28 Very High Very High Very High
medulla 22 82.08 Quite High
Inflammation 36 63.04 Quite High
Neuropeptide 2 38.56 Quite Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
rheumatoid arthritis 10 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 37 100.00 Very High Very High Very High
Disease 91 99.44 Very High Very High Very High
Psoriasis 70 98.94 Very High Very High Very High
Wound Healing 12 96.32 Very High Very High Very High
Chronic Fatigue Syndrome 184 94.28 High High
Targeted Disruption 57 82.88 Quite High
Cognitive Disorder 1 66.88 Quite High
INFLAMMATION 33 63.04 Quite High
Alzheimer's Dementia 14 55.76 Quite High
Skin Appendage Disease 9 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More recent experimental studies showed that after skin wounding, K6 and K16 are rapidly induced within 6 h in human keratinocytes at the wound edge, before migration and regeneration begins (Paladini et al. 1996).
Positive_regulation (induced) of K16 in keratinocytes associated with injury
1) Confidence 0.44 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.23 Pain Relevance 0
Keratin 16 is upregulated in epidermal diseases such as psoriasis [99].
Positive_regulation (upregulated) of Keratin 16 associated with psoriasis and disease
2) Confidence 0.41 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.63 Pain Relevance 0.24
In early immunohistochemical studies using keratin group-specific MAbs, Weiss et al. (1984) demonstrated the induction of K6 (56-kd keratin) and K16 (48-kd keratin) in various hyperproliferative epidermal disorders, suggesting that these keratins may be molecular markers for hyperproliferative keratinocytes.
Positive_regulation (induction) of K16 in keratinocytes
3) Confidence 0.38 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.08 Pain Relevance 0
Another interesting feature of K17 is its inducibility after skin injury: after K6/K16 (see above), K17 is switched on in regenerating and migrating epidermal keratinocytes upon wound healing (Paladini et al. 1996).
Positive_regulation (inducibility) of K16 in skin associated with wound healing and injury
4) Confidence 0.30 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.52 Pain Relevance 0
This cytokine mixture was recently found to be optimal for induction of a psoriatic phenotype in vitro, as witnessed by high expression levels of CK16, SKALP/elafin and hBD-2 [36]. qPCR analysis of isolated epidermal sheets indicated that hBD-2 mRNA levels (determined as deltaCt values) in these cultures were much higher than in keratinocytes from submerged cultures (not shown), and reached similar high values as found in epidermal sheets from lesional psoriatic skin (see figure 1).
Positive_regulation (levels) of CK16 in keratinocytes associated with psoriasis and cytokine
5) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 0.44 Pain Relevance 0.17

General Comments

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