INT189230

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 31
Disease Relevance 25.04
Pain Relevance 7.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
plasma 8
blood 4
cerebrospinal fluid 3
neuronal 1
liver 1
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 1180 100.00 Very High Very High Very High
Inflammation 320 100.00 Very High Very High Very High
imagery 20 99.72 Very High Very High Very High
rheumatoid arthritis 433 99.56 Very High Very High Very High
Inflammatory mediators 27 99.56 Very High Very High Very High
cva 5 87.04 High High
Abeta 20 84.96 Quite High
intrathecal 20 67.44 Quite High
cytokine 21 58.04 Quite High
Central nervous system 56 42.60 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 1200 100.00 Very High Very High Very High
INFLAMMATION 338 100.00 Very High Very High Very High
Injury 149 100.00 Very High Very High Very High
Rheumatoid Arthritis 433 99.56 Very High Very High Very High
Sepsis 67 98.40 Very High Very High Very High
Amyloidosis 9 98.36 Very High Very High Very High
Burns 18 98.00 Very High Very High Very High
Anaerobic Bacterial Infections 29 97.36 Very High Very High Very High
Hepatitis 20 96.84 Very High Very High Very High
Myocardial Infarction 20 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our previous study showed that GSN present in CSF of MS patients consists predominantly of its plasma isoform, and using immunoblotting assays, we have not observed any cleavage products of pGSN in CSF [30].
Gene_expression (present) of GSN in plasma associated with multiple sclerosis
1) Confidence 0.75 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.80 Pain Relevance 0.36
Our previous study showed that GSN present in CSF of MS patients consists predominantly of its plasma isoform, and using immunoblotting assays, we have not observed any cleavage products of pGSN in CSF [30].
Gene_expression (products) of pGSN in plasma associated with multiple sclerosis
2) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.78 Pain Relevance 0.35
The QAlb values indicate lack of CSF-barrier dysfunction in MS subjects included in our study, and it is very likely that the depletion of GSN and DBP from CSF that occurs as these proteins bind actin cannot be compensated for by an increased production or transport of gelsolin.
Gene_expression (production) of gelsolin associated with multiple sclerosis
3) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.75 Pain Relevance 0.36
However, due to some small CSF specimens, we were able to perform both gelsolin and DBP analysis in only 24 samples.


Gene_expression (analysis) of gelsolin
4) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.69 Pain Relevance 0.25
Additionally, an analysis using Pearson's test indicated a weak correlation between gelsolin levels in CSF and its level in blood.
Gene_expression (levels) of gelsolin in blood
5) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.62 Pain Relevance 0.28
As plasma gelsolin has the ability to bind actin, blood gelsolin depletion was observed in diverse states of inflammation associated with tissue injury and actin release: adult respiratory distress syndrome, sepsis, myocardial infarction, hepatitis, myonecrosis and rheumatoid arthritis [4-7].
Gene_expression (depletion) of gelsolin in respiratory associated with rheumatoid arthritis, adult respiratory distress syndrome, sepsis, inflammation, injury, anaerobic bacterial infections, myocardial infarction and hepatitis
6) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.99 Pain Relevance 0.14
Following transfer, proteins were probed with a monoclonal anti-human gelsolin antibody (G4896, Sigma, St.
Gene_expression (antibody) of gelsolin
7) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.12 Pain Relevance 0.06
Similar to gelsolin depletion, low DBP levels (both the total level and the actin-free level, which is an index of residual actin-scavenging capacity), was proposed to serve as a prognostic marker in situations of organ damage such as acute liver failure, and multiple trauma [18].
Gene_expression (depletion) of gelsolin in liver associated with acute liver failure and multiple trauma
8) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.05 Pain Relevance 0.06
The decrease of GSN concentration in blood and CSF of MS subjects indicates the involvement of this protein in the process of neurodegenerative disease development.
Gene_expression (concentration) of GSN in blood associated with multiple sclerosis and neurodegenerative disease
9) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.19 Pain Relevance 0.41
However this correlation is weaker compared to that found for gelsolin levels in blood and CSF of MS subjects.
Gene_expression (levels) of gelsolin in blood associated with multiple sclerosis
10) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.51 Pain Relevance 0.25
In trauma patients, lower plasma gelsolin levels were associated with a poor prognosis [8].
Gene_expression (levels) of gelsolin in plasma associated with injury
11) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.13 Pain Relevance 0.13
Gelsolin and DBP concentration in cerebrospinal fluid
Gene_expression (concentration) of Gelsolin in cerebrospinal fluid
12) Confidence 0.65 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.81 Pain Relevance 0.36
On the other hand, in recent studies overexpression of gelsolin restored the impaired mitochondrial activity associated with CNS degeneration in the course of Alzheimer's disease (AD).
Gene_expression (overexpression) of gelsolin associated with disease
13) Confidence 0.58 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.54 Pain Relevance 0.53
CSF: cerebrospinal fluid; DBP: GC-globulin/Vitamin D-binding protein; EDSS: Expanded Disability Status Scale; GSN: gelsolin; MS: multiple sclerosis; MRI: Magnetic resonance imaging; QAlb: albumin CSF/serum quotient; SDS: sodium dodecyl sulfate.


Gene_expression (sclerosis) of GSN in cerebrospinal fluid associated with multiple sclerosis and imagery
14) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.88 Pain Relevance 0.37
At the same time, these results are in agreement with the sequestration hypothesis that was proposed as a mechanism of actin-mediated gelsolin depletion [34].
Gene_expression (depletion) of gelsolin
15) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.51 Pain Relevance 0.26
CSF: cerebrospinal fluid; DBP: GC-globulin/Vitamin D-binding protein; EDSS: Expanded Disability Status Scale; GSN: gelsolin; MS: multiple sclerosis; MRI: Magnetic resonance imaging; QAlb: albumin CSF/serum quotient; SDS: sodium dodecyl sulfate.


Gene_expression (sclerosis) of gelsolin in cerebrospinal fluid associated with multiple sclerosis and imagery
16) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.88 Pain Relevance 0.37
The average gelsolin concentration in the CSF of MS patients was significantly higher (p < 0.001) than the concentration of vitamin D binding protein, showing that these plasma proteins do not simply partition passively into the CSF.
Gene_expression (concentration) of gelsolin in plasma associated with multiple sclerosis
17) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.72 Pain Relevance 0.33
AK: participated in study design, collection of CSF samples, helped to draft the manuscript; NJC: carried out GSN studies; QW: statistical evaluation, helped to draft the manuscript; BM: carried out DBP studies helped to draft the manuscript; WD: participated in study design, helped to draft the manuscript; MS: participated in study design, helped to draft the manuscript; PAJ: participated in study design, helped to draft the manuscript; RB: carried out F-actin studies, participated in study design, helped to draft the manuscript.
Gene_expression (studies) of GSN associated with multiple sclerosis
18) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.42 Pain Relevance 0.17
Here we report that average gelsolin concentrations in CSF collected from patients diagnosed with MS was lower (2.9 ± 1.8 versus 4.1 ± 1.7 ?
Gene_expression (concentrations) of gelsolin associated with multiple sclerosis
19) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.78 Pain Relevance 0.35
Here we report that average gelsolin concentrations in CSF collected from patients diagnosed with MS was lower (2.9 ± 1.8 versus 4.1 ± 1.7 ?
Gene_expression (average) of gelsolin associated with multiple sclerosis
20) Confidence 0.57 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.78 Pain Relevance 0.35

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