INT189232

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.03
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CHGB)
Anatomy Link Frequency
adrenal medulla 1
CHGB (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 6 99.76 Very High Very High Very High
medulla 6 97.00 Very High Very High Very High
Pain 25 84.96 Quite High
Inflammation 18 83.88 Quite High
cva 10 53.04 Quite High
Inflammatory stimuli 2 35.68 Quite Low
Fibrositis 48 5.00 Very Low Very Low Very Low
Central nervous system 32 5.00 Very Low Very Low Very Low
Calcium channel 17 5.00 Very Low Very Low Very Low
spastic colon 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 29 93.92 High High
Alzheimer's Dementia 28 85.16 High High
Pain 27 84.96 Quite High
INFLAMMATION 21 83.88 Quite High
Disorder Of Lipid Metabolism 10 60.16 Quite High
Syndrome 78 58.24 Quite High
Cerebral Amyloid Angiopathy 22 57.84 Quite High
Cv General 3 Under Development 6 53.04 Quite High
Amyloidosis 18 52.76 Quite High
Chronic Fatigue Syndrome 368 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chromogranin B (CGB) is a prohormone that can be cleaved to release secretogranin I precursor (Sg1), GAWK and CCB peptides.
Localization (release) of secretogranin I precursor
1) Confidence 0.24 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.85 Pain Relevance 0.03
Chromogranin B (CGB) is a prohormone that can be cleaved to release secretogranin I precursor (Sg1), GAWK and CCB peptides.
Localization (release) of Sg1
2) Confidence 0.24 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.85 Pain Relevance 0.03
We have identified a range of antimicrobial peptides deriving from the natural processing, not only of CgA but also Chromogranin B, Proenkephalin-A and Ubiquitin co-secreted with catecholamines upon stimulation of chromaffin cells from the adrenal medulla [17], [18], [22]–[25].
Localization (secreted) of Chromogranin B in adrenal medulla associated with medulla and catecholamine
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.34 Pain Relevance 0.33

General Comments

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