INT189236

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.07
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HP)
HP (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 16 94.40 High High
antidepressant 9 83.68 Quite High
depression 31 77.60 Quite High
Fibrositis 24 65.40 Quite High
Pain threshold 2 45.08 Quite Low
spastic colon 5 38.08 Quite Low
Pain 14 33.44 Quite Low
Hyperalgesia 3 32.48 Quite Low
nMDA receptor antagonist 1 29.68 Quite Low
Morphine 4 5.76 Low Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 372 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 6 90.04 High High
Learning Disorders 8 89.68 High High
Chronic Fatigue Syndrome 184 88.92 High High
Attention Deficit Hyperactivity Disorder 44 88.76 High High
Alzheimer's Dementia 14 87.84 High High
Epilepsy 3 80.44 Quite High
Depression 43 77.60 Quite High
Convulsion 4 77.52 Quite High
Anxiety Disorder 12 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-1-antichymotrypsin; the metal transport and antioxidant proteins ceruloplasmin (ferroxidase II), haptoglobin and orosomucoid 2 (ORM2; ?
Transcription (proteins) of haptoglobin
1) Confidence 0.28 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 0.64 Pain Relevance 0.08
Tightening the definition of BP and beginning to define a new diagnosis
Transcription (definition) of BP associated with manic depressive disorder
2) Confidence 0.07 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 1.38 Pain Relevance 0
Gabrielle Carlson responded that even if many of the same medications are prescribed for BP and some of its diagnostic cousins, the overall treatment plans and prognoses for the children are different.
Transcription (prescribed) of BP associated with manic depressive disorder
3) Confidence 0.07 Published 2010 Journal Child Adolesc Psychiatry Ment Health Section Body Doc Link PMC2846895 Disease Relevance 1.05 Pain Relevance 0.08
Overall, our statistical analyses indicate that the MAF matrix has a complex structure that is correlated with the geometry of the ligand molecules and the protein itself; however, it cannot be sufficiently described by binding site shape descriptors.
Neg (cannot) Transcription (described) of binding
4) Confidence 0.04 Published 2010 Journal BMC Struct Biol Section Body Doc Link PMC2972294 Disease Relevance 0 Pain Relevance 0

General Comments

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