INT189239

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 14
Disease Relevance 9.34
Pain Relevance 1.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSN) extracellular space (GSN) vesicle-mediated transport (GSN)
aging (GSN) extracellular region (GSN) protein complex (GSN)
Anatomy Link Frequency
Plasma 3
joint 2
platelet 2
GSN (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 254 99.96 Very High Very High Very High
Inflammatory mediators 27 99.52 Very High Very High Very High
rheumatoid arthritis 353 99.40 Very High Very High Very High
Glutamate 1 95.76 Very High Very High Very High
Multiple sclerosis 236 94.80 High High
Central nervous system 20 88.24 High High
metalloproteinase 27 85.96 High High
Immobilon 9 33.76 Quite Low
methotrexate 63 5.00 Very Low Very Low Very Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 272 99.96 Very High Very High Very High
Chronic Fatigue Syndrome 184 99.92 Very High Very High Very High
Rheumatoid Arthritis 353 99.40 Very High Very High Very High
Apoptosis 12 97.60 Very High Very High Very High
Injury 117 97.52 Very High Very High Very High
Toxicity 4 97.48 Very High Very High Very High
Disseminated Intravascular Coagulation 4 96.96 Very High Very High Very High
Sepsis 35 95.64 Very High Very High Very High
Demyelinating Disease 240 94.80 High High
Multiple Trauma 4 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the actin scavenging system, gelsolin depolymerizes F-actin and DBP binds monomeric G-actin in order to prevent polymerization.
gelsolin Binding (depolymerizes) of
1) Confidence 0.36 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.09 Pain Relevance 0.07
Gelsolin was shown to preferentially bind lysophosphatidic acid, platelet-activating factor, endotoxin, and lipoteichoic acid [20-22].
Gelsolin Binding (bind) of in platelet
2) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.76 Pain Relevance 0.11
In addition to actin, gelsolin and DBP bind important bioactive lipids.
gelsolin Binding (bind) of
3) Confidence 0.35 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.75 Pain Relevance 0.11
Plasma gelsolin (pGSN) is the extracellular isoform of a ubiquitous cytoplasmic actin-binding protein, gelsolin (GSN), that mediates cell shape changes and motility [1].
GSN Binding (binding) of in Plasma
4) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.26 Pain Relevance 0.05
Plasma gelsolin (pGSN) is the extracellular isoform of a ubiquitous cytoplasmic actin-binding protein, gelsolin (GSN), that mediates cell shape changes and motility [1].
gelsolin Binding (binding) of in Plasma
5) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.26 Pain Relevance 0.05
Gelsolin's interaction with bioactive lipids can alter its ability to bind actin [24].
Gelsolin Binding (interaction) of
6) Confidence 0.31 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.85 Pain Relevance 0.16
In addition to its high affinity for actin, a prime candidate for its localization at an inflamed site containing damaged cells, pGSN binds to fibronectin [37] and fibrin [38,39], which are present at higher-than-normal concentrations in the inflamed joint space during RA [40-42].
pGSN Binding (binds) of in joint associated with rheumatoid arthritis
7) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 1.08 Pain Relevance 0.34
Such complexes would be interpreted as pGSN in the nucleation assay and contribute to the total pGSN concentration measured in the patient sample. pGSN stuck in the damaged tissue would not be detected.
pGSN Binding (interpreted) of
8) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.43 Pain Relevance 0.14
Since pGSN has previously been shown to bind to various inflammatory mediators such as platelet-activating factor, lysophosphatidic acid, and endotoxin, some of which are present at higher-than-normal levels in the inflamed synovial joint of RA patients [44], further studies should be conducted to understand how this local consumption due to compartmental actin binding affects cell activation induced by these mediators.
pGSN Binding (bind) of in platelet associated with inflammatory mediators and rheumatoid arthritis
9) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.37 Pain Relevance 0.13
Mechanistically, pGSN may be consumed locally through trapping at the joint space or other affected organs in order to maintain a steady-state concentration at the site of inflammation. pGSN has the potential to interact with several macromolecules present at sites of inflammatory injury.
pGSN Binding (interact) of in joint associated with inflammation and injury
10) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 1.25 Pain Relevance 0.42
A fraction of the actin-bound pGSN would be expected to come loose from the network during the severing process and be detected as free-floating pGSN-actin complexes in SF.
pGSN Binding (complexes) of
11) Confidence 0.31 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.48 Pain Relevance 0.16
Gelsolin is an intracellular actin-binding protein involved in cell shape changes, cell motility, and apoptosis.
Gelsolin Binding (binding) of associated with apoptosis
12) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2592804 Disease Relevance 0.58 Pain Relevance 0.11
To confirm that the 2c4 antibody recognizes pGSN cleaved by MMPs into fragments and that cleavage can occur in plasma, rhpGSN (115 nM) or dilute human plasma (approximately 115 nM pGSN) was incubated with catalytic domain of MMP-3 (cMMP-3) (230 nM) (Sigma-Aldrich, St.
pGSN Binding (recognizes) of in plasma
13) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0 Pain Relevance 0.04
Gelsolin was associated with CFS status.
Gelsolin Binding (associated) of associated with chronic fatigue syndrome
14) Confidence 0.15 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.19 Pain Relevance 0.05

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