INT189283

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.63
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

MHC II protein (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 182 99.80 Very High Very High Very High
rheumatoid arthritis 2 89.00 High High
Multiple sclerosis 28 73.20 Quite High
agonist 4 69.92 Quite High
5HT 6 16.28 Low Low
Central nervous system 26 5.00 Very Low Very Low Very Low
depression 16 5.00 Very Low Very Low Very Low
Kinase C 14 5.00 Very Low Very Low Very Low
Pain 14 5.00 Very Low Very Low Very Low
Fibrositis 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thyroiditis 2 90.80 High High
Hyperthyroidism 2 89.64 High High
Rheumatoid Arthritis 2 89.00 High High
Autoimmune Disease 8 88.56 High High
Diabetes Mellitus-type I 6 83.24 Quite High
Diabetes Mellitus 6 83.00 Quite High
Systemic Lupus Erythematosus 2 76.80 Quite High
Myocardial Infarction 26 76.04 Quite High
Demyelinating Disease 28 73.20 Quite High
Breast Cancer 42 64.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Women in whom estrogen-regulated serotonin signaling is compromised would be expected to have higher levels of MHC class II protein expression and may present these pathologies.
Gene_expression (expression) of MHC class II protein associated with serotonin
1) Confidence 0.23 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.05 Pain Relevance 0.23
Estrogen treatment also indirectly suppresses MHC II protein expression via serotonin [102,106].
Gene_expression (expression) of MHC II protein associated with serotonin
2) Confidence 0.18 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.58 Pain Relevance 0.16

General Comments

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