INT189284

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Context Info
Confidence 0.20
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.82
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 91 99.12 Very High Very High Very High
agonist 12 94.48 High High
substance P 11 59.20 Quite High
Inflammatory mediators 1 32.64 Quite Low
rheumatoid arthritis 1 5.80 Low Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Multiple sclerosis 14 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Kinase C 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 27 100.00 Very High Very High Very High
Breast Cancer 21 99.64 Very High Very High Very High
Apoptosis 5 93.96 High High
Cancer 4 88.72 High High
Metastasis 1 51.92 Quite High
Autoimmune Disease 4 35.16 Quite Low
INFLAMMATION 1 32.64 Quite Low
Increased Venous Pressure Under Development 10 19.04 Low Low
Thyroiditis 1 7.60 Low Low
Hyperthyroidism 1 6.44 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mediates the inhibitory effect of E2 (after 24 h) on Tac1 expression.
Positive_regulation (mediates) of Negative_regulation (effect) of E2
1) Confidence 0.20 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2724541 Disease Relevance 0 Pain Relevance 0.15
Therefore, if E2 is acting on breast cancer in part by serotonin modulation, then we would predict that the decrease in E2 after menopause should increase risk of breast cancer.
Positive_regulation (increase) of Negative_regulation (decrease) of E2 associated with endometriosis (extended), breast cancer and serotonin
2) Confidence 0.17 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.82 Pain Relevance 0.13

General Comments

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