INT189287

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 12
Disease Relevance 6.90
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Atp6v1e1) endosome (Atp6v1e1) transport (Atp6v1e1)
mitochondrion (Atp6v1e1) cytoplasm (Atp6v1e1)
Anatomy Link Frequency
embryonic stage 2
Blood 1
liver 1
Atp6v1e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 182 99.80 Very High Very High Very High
Arthritis 82 98.92 Very High Very High Very High
rheumatoid arthritis 14 96.76 Very High Very High Very High
Inflammation 42 94.68 High High
antagonist 15 89.20 High High
agonist 56 71.20 Quite High
Central nervous system 26 56.56 Quite High
adenocard 4 54.36 Quite High
Inflammatory response 4 50.00 Quite Low
Pain 14 47.36 Quite Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 26 99.24 Very High Very High Very High
Experimental Arthritis 49 98.92 Very High Very High Very High
Obesity 806 98.32 Very High Very High Very High
Body Weight 429 98.00 Very High Very High Very High
Rheumatoid Arthritis 14 96.76 Very High Very High Very High
INFLAMMATION 49 94.68 High High
Overactive Bladder 2 93.88 High High
Heart Disease 2 93.32 High High
Arthritis 41 92.88 High High
Pressure And Volume Under Development 16 91.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects can be accounted for without reference to the interaction between E2 and serotonin.
E2 Binding (interaction) of associated with serotonin
1) Confidence 0.19 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 0.27 Pain Relevance 0.36
E2 acting at ER?
E2 Binding (acting) of
2) Confidence 0.15 Published 2005 Journal BMC Womens Health Section Body Doc Link PMC1327664 Disease Relevance 1.09 Pain Relevance 0.23
coactivator recruitment by E2.
E2 Binding (recruitment) of
3) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.00 Pain Relevance 0
However, these reductions were not enhanced when mice were concomitantly treated with fenofibrate and E2, indicating that E2 may inhibit the function of PPAR?
E2 Binding (treated) of
4) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.25 Pain Relevance 0
transactivation, as indicated by the inability of E2 to stimulate PPAR?
E2 Binding (inability) of
5) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0 Pain Relevance 0
The inhibitory activity by E2 is mediated through its binding to endogenous ERs that are normally expressed in NMu2Li liver cells since it is reported that E2 does not bind directly PPARs [98].
E2 Binding (bind) of in liver
6) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.37 Pain Relevance 0
However, the possibility that E2 directly binds to PPAR?
E2 Binding (binds) of
7) Confidence 0.13 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 0.36 Pain Relevance 0
Similarly, the combination of E2 and fenofibrate did not result in any additional beneficial effects on lipid metabolism in female OVX mice.
E2 Binding (combination) of
8) Confidence 0.12 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.30 Pain Relevance 0
Because the binding activity of AFP for E2 depends on conditions [18,25] such as carbohydrate modifications, embryonic stage (15-18 days of gestation) and purification methods, crude serum samples were used for monitoring the in vivo states affecting brain development.
E2 Binding (activity) of in embryonic stage
9) Confidence 0.10 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0 Pain Relevance 0
Because the binding activity of AFP for E2 depends on conditions [18,25] such as carbohydrate modifications, embryonic stage (15-18 days of gestation) and purification methods, crude serum samples were used for monitoring the in vivo states affecting brain development.
E2 Binding (binding) of in embryonic stage
10) Confidence 0.10 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0 Pain Relevance 0
Blood from each embryo was taken by heart puncture, from which the same volumes of sera after removing the blood cells were used to determine the binding activities for E2 and for western analysis.
E2 Binding (binding) of in Blood
11) Confidence 0.08 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0 Pain Relevance 0
In experimental arthritis, most studies report an immune suppressive effect of E2 or EE, which bind both ERs in an agonistic mode [23,24].
E2 Binding (bind) of associated with experimental arthritis and arthritis
12) Confidence 0.04 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.24 Pain Relevance 0.55

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