INT18930

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Context Info
Confidence 0.63
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 20
Total Number 24
Disease Relevance 7.77
Pain Relevance 12.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
neurons 2
sensory neuron 1
aorta 1
NG108-15 1
fibroblasts 1
Hrh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 7 100.00 Very High Very High Very High
MU agonist 9 99.98 Very High Very High Very High
Serotonin 1 99.78 Very High Very High Very High
Neuritis 8 99.58 Very High Very High Very High
Gabapentin 13 99.52 Very High Very High Very High
Opioid 38 99.50 Very High Very High Very High
Morphine 17 99.44 Very High Very High Very High
Kinase C 3 99.28 Very High Very High Very High
nociceptor 16 98.80 Very High Very High Very High
Delta opioid receptors 3 98.62 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 31 100.00 Very High Very High Very High
Disease 14 100.00 Very High Very High Very High
Neuroblastoma 2 100.00 Very High Very High Very High
Pruritus 303 99.96 Very High Very High Very High
Experimental Autoimmune Neuritis 8 99.58 Very High Very High Very High
Nociception 25 99.52 Very High Very High Very High
Cv General 3 Under Development 2 98.52 Very High Very High Very High
Inflammatory Pain 1 96.44 Very High Very High Very High
Ganglion Cysts 6 95.96 Very High Very High Very High
Targeted Disruption 6 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased effect does not appear to be due to induced metabolism but may be related to increased H1 receptor number.
Positive_regulation (increased) of H1 receptor
1) Confidence 0.63 Published 1985 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 4008807 Disease Relevance 0.06 Pain Relevance 0.10
The contribution of histamine H1 and H2 receptors to the thermoregulatory effect of morphine in mice was investigated in the present experiments.
Spec (investigated) Positive_regulation (contribution) of histamine H1 associated with morphine
2) Confidence 0.50 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8836631 Disease Relevance 0 Pain Relevance 0.67
The present results suggest that histamine sensitizes acid-induced responses through TRPV1 activation via H1R coupled with PLC/PKC pathways, the action of which may be involved in the generation of inflammatory pain.
Positive_regulation (activation) of H1R associated with kinase c and ipn
3) Confidence 0.47 Published 2010 Journal Neuroscience Section Abstract Doc Link 20006972 Disease Relevance 0.76 Pain Relevance 0.78
Summarizing, it appears that activated H1R and H4R are involved in the induction of itch, whereas H3R acts in the reverse manner.
Positive_regulation (activated) of H1R associated with pruritus
4) Confidence 0.42 Published 2008 Journal Mol Pain Section Body Doc Link PMC2519061 Disease Relevance 0.55 Pain Relevance 0.39
Therefore, the role of H3R in the mediation of histamine-induced itch seems minor.
Positive_regulation (mediation) of histamine-induced associated with pruritus
5) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2519061 Disease Relevance 0.51 Pain Relevance 0.24
On the other hand, stimulation of phospholipase A2 (PLA2) by H1R was found to mediate histamine-induced sensory neuron excitation [29,30].
Positive_regulation (mediate) of histamine-induced in sensory neuron
6) Confidence 0.39 Published 2008 Journal Mol Pain Section Body Doc Link PMC2519061 Disease Relevance 0.30 Pain Relevance 0.29
The present results indicate that the activation of pertussis toxin-sensitive G-proteins represents an important transduction step in the central analgesia induced by opioids, antihistaminics, GABAB (gamma-aminobutyric acid B) agonists and tricyclic antidepressants, but not by cholinomimetics.
Positive_regulation (activation) of pertussis toxin-sensitive associated with bordatella infection, agonist, tricyclic antidepressant, opioid and analgesia
7) Confidence 0.35 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8840123 Disease Relevance 0.52 Pain Relevance 0.96
It is therefore suggested that H1 receptor activation increases sensitivity to noxious stimuli.
Positive_regulation (activation) of H1 receptor
8) Confidence 0.29 Published 1998 Journal Life Sci. Section Abstract Doc Link 9718070 Disease Relevance 0.28 Pain Relevance 0.54
H1 receptor stimulation of the coronary artery was performed with a selective intracoronary infusion of histamine (2 micrograms/min) in 21 patients with variant angina after blockade of the H2 receptor with cimetidine (25 mg/kg) and its effect on the coronary artery diameter was examined.
Spec (examined) Positive_regulation (stimulation) of H1 receptor in coronary artery associated with angina
9) Confidence 0.26 Published 1991 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 1991889 Disease Relevance 0.27 Pain Relevance 0.22
Evidence for hypernociception induction following histamine H1 receptor activation in rodents.
Positive_regulation (activation) of H1 receptor associated with nociceptor
10) Confidence 0.25 Published 1998 Journal Life Sci. Section Title Doc Link 9718070 Disease Relevance 0.28 Pain Relevance 0.81
Its antinociceptive effect involves multiple mechanisms of action, namely interaction with mu, delta, or kappa opioid systems, L-arginine-nitric oxide and serotonin pathways, activation of Gi protein sensitive to pertussis toxin, and modulation by endogenous glucocorticoids.
Positive_regulation (activation) of pertussis toxin associated with bordatella infection, serotonin, opioid and antinociceptive
11) Confidence 0.14 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10087033 Disease Relevance 0.40 Pain Relevance 0.90
Experimental allergic neuritis in the SJL/J mouse: induction of severe and reproducible disease with bovine peripheral nerve myelin and pertussis toxin with or without interleukin-12.
Positive_regulation (induction) of pertussis toxin in peripheral nerve associated with bordatella infection, experimental autoimmune neuritis, disease and neuritis
12) Confidence 0.13 Published 2000 Journal J. Neuroimmunol. Section Title Doc Link 10808045 Disease Relevance 1.17 Pain Relevance 0.78
Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s).
Positive_regulation (elevation) of pertussis toxin in fibroblasts associated with bordatella infection
13) Confidence 0.12 Published 1993 Journal Mol. Pharmacol. Section Title Doc Link 8396718 Disease Relevance 0.10 Pain Relevance 0.24
These results strongly suggested that both excitation and facilitation of the heat response induced by histamine are mediated through the H1 receptor.
Positive_regulation (mediated) of H1 receptor
14) Confidence 0.12 Published 1996 Journal J. Neurophysiol. Section Abstract Doc Link 8890260 Disease Relevance 0 Pain Relevance 0.26
Pretreatment of mouse striatal neurons in primary culture with 17 beta-estradiol enhances the pertussis toxin-catalyzed ADP-ribosylation of G alpha o,i protein subunits.
Positive_regulation (enhances) of pertussis toxin in neurons associated with bordatella infection
15) Confidence 0.03 Published 1990 Journal J. Neurochem. Section Title Doc Link 2118945 Disease Relevance 0.28 Pain Relevance 0.16
Like N/OFQ, nocistatin-induced nociception was abolished by i.pl. injection of pertussis toxin, phospholipase C inhibitor, or CP-99994, a neurokinin 1 receptor antagonist, indicating that nocistatin may elicit nociception through a substance P release from nociceptor endings via activation of Gi/o and phospholipase C.
Positive_regulation (injection) of pertussis toxin in nociceptor associated with nociception, bordatella infection, nociceptor, antagonist and substance p
16) Confidence 0.02 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12665541 Disease Relevance 0.68 Pain Relevance 0.79
Activation of P2-purino-, alpha 1-adreno and H1-histamine receptors triggers cytoplasmic calcium signalling in cerebellar Purkinje neurons.
Positive_regulation (Activation) of H1-histamine in neurons
17) Confidence 0.01 Published 1996 Journal Neuroscience Section Title Doc Link 8809785 Disease Relevance 0 Pain Relevance 0.29
Thus, in the rabbit aorta, methanandamide-induced vasorelaxation exhibits two components: 1) in endothelium-intact rings, an SR141716A-sensitive, non-CB(1) receptor component that requires pertussis toxin-sensitive G proteins and nitric oxide (NO) production; and 2) in endothelium-denuded rings, a component that is mediated by VR(1) vanilloid receptors and possibly by the subsequent release of CGRP that requires NO production but is independent of pertussis toxin-sensitive G proteins.
Positive_regulation (requires) of pertussis toxin-sensitive in aorta associated with bordatella infection and calcitonin gene-related peptide
18) Confidence 0.00 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12003810 Disease Relevance 0.36 Pain Relevance 0.37
In a previous study, we showed that microM concentrations of mu or delta opioid agonists increase voltage-dependent outward K+ currents in neuroblastoma x DRG neuron hybrid F11 cells via pertussis toxin-sensitive receptors.
Positive_regulation (increase) of pertussis toxin-sensitive in F11 associated with neuroblastoma, mu agonist and bordatella infection
19) Confidence 0.00 Published 1993 Journal Brain Res. Section Abstract Doc Link 8386968 Disease Relevance 0.43 Pain Relevance 0.59
This process may be inhibited by activation of the kappa opioid receptor through pertussis toxin-sensitive G protein(s).
Positive_regulation (activation) of pertussis toxin-sensitive associated with bordatella infection and kappa opioid receptor
20) Confidence 0.00 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9223581 Disease Relevance 0.24 Pain Relevance 0.31

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