INT189309

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) peptidase activity (MME) extracellular region (PENK)
plasma membrane (MME) cell-cell signaling (MME)
Anatomy Link Frequency
epithelial cells 2
MME (Homo sapiens)
PENK (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 8 76.64 Quite High
superficial lamina 10 22.68 Low Low
Opioid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 64 99.56 Very High Very High Very High
Pancreatic Cancer 2 86.40 High High
Fibrosarcoma 2 50.56 Quite High
Prostate Cancer 14 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Bladder Cancer 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previously, we showed that cancer epithelial cells are CD10 negative [11], which would further suggest a link between PENK and CD10 as defects in enkephalinase activity may be associated with decreased PENK expression in cancer.
CD10 Binding (link) of PENK in epithelial cells associated with cancer
1) Confidence 0.15 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0.56 Pain Relevance 0.21
Previously, we showed that cancer epithelial cells are CD10 negative [11], which would further suggest a link between PENK and CD10 as defects in enkephalinase activity may be associated with decreased PENK expression in cancer.
CD10 Binding (link) of PENK in epithelial cells associated with cancer
2) Confidence 0.15 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0.60 Pain Relevance 0.21

General Comments

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