INT189313

Context Info Confidence 0.29 First Reported 2005 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 2.35 Pain Relevance 0.62

extracellular region (STC2) cell-cell signaling (STC2)

Anatomy Link Frequency mesenchymal cells 1 STC2 (Homo sapiens)

Pain Link Frequency Relevance Heat cva 136 99.92 Enkephalin 4 51.40 superficial lamina 5 5.00 cerebral cortex 4 5.00 epidural 2 5.00 agonist 2 5.00 anesthesia 1 5.00 ischemia 1 5.00 Deep tissue 1 5.00 Dopamine 1 5.00

Disease Link Frequency Relevance Heat Cv General 3 Under Development 133 99.92 Fibrosarcoma 1 98.76 Cancer 32 98.12 Cerebral Hypoxia 5 97.76 Brain Injury 26 92.92 Pancreatic Cancer 1 85.28 Coma 4 18.56 Brain Death 1 17.36 Injury 12 5.00 Prostate Cancer 7 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both STC1 and STC2 are reported to be secreted as phosphoproteins from human fibrosarcoma, a tumor of mesenchymal cells [22].

Localization (secreted) of STC2 in mesenchymal cells associated with fibrosarcoma and cancer

1) Confidence 0.29 Published 2005 Journal BMC Urol Section Body Doc Link PMC1327674 Disease Relevance 0.72 Pain Relevance 0.05

With increased ICP or decreased CPP, StcO2 is reduced.

Localization (decreased) of StcO2 associated with cva

2) Confidence 0.02 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.63 Pain Relevance 0.56

General Comments

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