INT189322

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 12.10
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (A2M) extracellular space (A2M) extracellular region (A2M)
enzyme binding (A2M)
Anatomy Link Frequency
plasma 4
platelet 1
A2M (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 608 99.92 Very High Very High Very High
Inflammation 61 77.72 Quite High
alcohol 86 32.72 Quite Low
imagery 12 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 83 100.00 Very High Very High Very High
Cirrhosis 162 99.92 Very High Very High Very High
Insulin Resistance 35 99.36 Very High Very High Very High
Fatty Liver 281 99.06 Very High Very High Very High
Diabetes Mellitus 49 98.48 Very High Very High Very High
Hepatitis 103 98.12 Very High Very High Very High
Obesity 61 96.92 Very High Very High Very High
Fibrosis 572 96.04 Very High Very High Very High
Congenital Anomalies 5 94.20 High High
Liver Disease 73 93.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with NAFLD we previously demonstrated a very significant association between A2M and insulin levels, a hallmark of insulin resistance [25].
A2M Binding (association) of associated with fatty liver and insulin resistance
1) Confidence 0.29 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.30 Pain Relevance 0.04
Insulin is covalently bound to A2M [42] in plasma and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [43].
A2M Binding (binding) of in plasma
2) Confidence 0.29 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.54 Pain Relevance 0.04
A2M is a protease inhibitor but also has multiple functions as a binding, carrier and targeting protein [40].
A2M Binding (binding) of
3) Confidence 0.28 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.43 Pain Relevance 0.05
Insulin is covalently bound to A2M [42] in plasma and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [43].
A2M Binding (binding) of in plasma
4) Confidence 0.25 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1657015 Disease Relevance 1.55 Pain Relevance 0.04
A2M is associated with several growth factors: fibroblast, vascular endothelial, epidermal, transforming and platelet derived growth factors [19].
A2M Binding (associated) of in platelet
5) Confidence 0.16 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 0.81 Pain Relevance 0.08
Insulin is covalently bound to A2M in plasma [49] and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [50].
A2M Binding (binding) of in plasma
6) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.35 Pain Relevance 0.10
Insulin is covalently bound to A2M in plasma [49] and A2M is a binding protein of Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) which modifies the IGFBP-1/IGF interaction [50].
A2M Binding (bound) of in plasma
7) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.29 Pain Relevance 0.10
Interestingly, in patients with NAFLD, the present study demonstrated a very significant association between A2M and insulin levels, a hallmark of insulin resistance.
A2M Binding (association) of associated with fatty liver and insulin resistance
8) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 1.03 Pain Relevance 0.07
A2M is a protease inhibitor, but also has multiple functions as a binding, carrier and targeting protein [46].
A2M Binding (binding) of
9) Confidence 0.14 Published 2006 Journal BMC Gastroenterol Section Body Doc Link PMC1386692 Disease Relevance 0.83 Pain Relevance 0.09
2-macroglobulin (A2M), apolipoprotein A-I (ApoA1), haptoglobin, total bilirubin, GGT, cholesterol, triglycerides, glucose, age, gender and BMI.
A2M Binding (haptoglobin) of associated with obesity and disorder of lipid metabolism
10) Confidence 0.06 Published 2005 Journal Comp Hepatol Section Body Doc Link PMC1327680 Disease Relevance 0.97 Pain Relevance 0.04

General Comments

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