INT189335

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 0.07
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Rpa1) nucleus (Rpa1) DNA binding (Rpa1)
cytoplasm (Rpa1)
Rpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 40 90.48 High High
long-term potentiation 32 88.00 High High
interneuron 8 82.72 Quite High
Central nervous system 16 76.60 Quite High
Kinase C 8 66.48 Quite High
gABA 88 30.52 Quite Low
depression 72 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
Serotonin 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 16 66.48 Quite High
Cockayne Syndrome 10 50.00 Quite Low
Targeted Disruption 1 36.44 Quite Low
Depression 72 5.00 Very Low Very Low Very Low
Genomic Instability 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Premature Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulatory mechanism of RP and its functional relevance
Gene_expression (mechanism) of RP
1) Confidence 0.07 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0.07 Pain Relevance 0.12
2 subunits (Laurie et al, 1992), CaMKII-mediated up-regulation of GABAAR might directly contribute to the expression of RP.
Gene_expression (expression) of RP
2) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Feedforward and feedback loops in a network contribute to the nonlinear performance of the system, and there are such loops in the signaling cascades regulating the RP induction.
Gene_expression (induction) of RP
3) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Verification of PDE1-mediated control of the [Ca2+]i threshold for RP induction
Gene_expression (induction) of RP
4) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Thus, PDE4 has a marginal role in the regulation of the [Ca2+]i threshold for RP induction.
Gene_expression (induction) of RP
5) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
2 subunits, is critical for the induction and maintenance of RP (Kawaguchi and Hirano, 2007).
Gene_expression (induction) of RP
6) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.03
Thus, we attempted to experimentally test the prediction that PDE1 has a predominant function in the [Ca2+]i threshold for RP induction.
Gene_expression (induction) of RP
7) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.05
When calcineurin was inhibited by an inhibitor, FK506 (300 nM), the conditioning stimulation consisting of 500-ms depolarization pulses, but not of shorter pulses induced RP (500 ms, 170±7%; 100 ms, 124±6%; 60 ms, 121±22%; 40 ms, 102±9%; 20 ms, 104±16%) (Figure 8F).
Gene_expression (induced) of RP
8) Confidence 0.06 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Under these conditions, there are approximately three RPA molecules per DNA binding site (given that the RPA binding footprint is ?
Gene_expression (is) of RPA binding footprint
9) Confidence 0.05 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1331990 Disease Relevance 0 Pain Relevance 0

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